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Antigenic Changes Associated with Chicken B Lymphocyte Development

  • R. L. Boyd
  • H. A. Ward
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 114)

Abstract

Analysis of changes in specific antigenic determinants during ontogeny constitutes one of the most practical methods for investigating lymphocyte differentiation pathways. Such studies have been very successful in mice, using alloantisera specific for T cells (reviews 1,2), but those of B cells have been largely restricted to alteration in immunoglobulin subclasses (3). We have approached this problem by identifying heteroantigens specific for B or T lymphocyte subpopulations using the chicken as a model (4) because of the clear lymphoid tissue dichotomy. These determinants were the chicken B lymphocyte-specific antigen (CBLA), chicken mature B lymphocyte-specific antigen (CMBLA), chicken foetal-associated antigen (CFAA), chicken T lymphocyte-specific antigen (CTLA) and chicken thymus-specific antigen (CTOA). From the analysis of the adult cellular representation and tissue localization of these determinants and immunoglobulin (Ig) and IgG (4), there appeared to be a progression of cells bearing immature to mature markers, each subclass being associated with different elements of the microenvironment.

Keywords

Germinal Centre Lymphocyte Antigen Lymphocyte Development Peripheral Lymphoid Tissue Antigenic Change 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Schlesinger, M., Prog. Allergy 16 (1972) 214.PubMedCrossRefGoogle Scholar
  2. 2.
    Greaves, M.F., Owen, J.J.T., Raff, M.C., T and B Lymphocytes: Origins, Properties and Roles in Immune Responses. American Elsevier Publishing Company, New York (1973).Google Scholar
  3. 3.
    Lawton, A.R., Kincade, P.W., Cooper, M.D., Fed. Proc. 34 (1975) 33.PubMedGoogle Scholar
  4. 4.
    Boyd, R.L., Ward, H.A., Immunol. 34 (1978) 9.Google Scholar
  5. 5.
    Boyd, R.L., Ward, H.A., Muller, H.K., Int. Arch. Allergy 50 (1976) 129.PubMedCrossRefGoogle Scholar
  6. 6.
    Nairn, R.C., Fluorescent Protein Tracing, 4th edn. Churchill Livingstone, Edinburgh (1976).Google Scholar
  7. 7.
    Kincade, P.W., Cooper, M.D., J. Immunol. 106 (1971) 1421.PubMedGoogle Scholar
  8. 8.
    Albini, B., Wick, G., Int. Arch. Allergy 44 (1973) 804.PubMedCrossRefGoogle Scholar
  9. 9.
    Hudson, L., Roitt, I.M., Europ. J. Immunol. 3 (1973) 63.CrossRefGoogle Scholar
  10. 10.
    Albini, B., Wick, G., Int. Arch. Allergy 48 (1975) 513.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1979

Authors and Affiliations

  • R. L. Boyd
    • 1
  • H. A. Ward
    • 1
  1. 1.Department of Pathology and ImmunologyMonash Medical SchoolMelbourneAustralia

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