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Function and Structure of the Immune System pp 655–660Cite as

Suppressor Cells in Trypanosoma Congolense-Infected Mice

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Part of the Advances in Experimental Medicine and Biology book series (AEMB,volume 114)

Summary

Spleen cells from mice infected with T. congolense strongly suppressed lymphocyte stimulation induced in normal spleen cells by incubation with mitogens or allogeneic cells. Cell dilution studies showed that suppressor activity was extremely strong. Suppressor cell activity was markedly reduced by treatment of spleen cell populations with mitomycin-C and was unaffected by treatment with anti-Thy.1 sera and complement. Removal of cells which bound carbonyl iron or which bound to nylon columns, decreased but did not abolish suppressor activity.

Keywords

  • Spleen Cell
  • Suppressor Cell
  • Suppressor Activity
  • Carbonyl Iron
  • Null Cell

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Roelants, G.E., Pearson, T.W., Mayor-Withey, K.S., Lundin, L.B., (Preceeding paper).

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Author information

Authors and Affiliations

  1. International Laboratory for Research on Animal Diseases (ILRAD), P.O. Box 30709, Nairobi, Kenya

    Terry W. Pearson, Georges E. Roelants, Lena B. Lundin & Kathleen S. Mayor-Withey

Authors
  1. Terry W. Pearson
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  2. Georges E. Roelants
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  3. Lena B. Lundin
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  4. Kathleen S. Mayor-Withey
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Editor information

Editors and Affiliations

  1. University of Kiel, Kiel, Germany

    Wolfgang Müller-Ruchholtz & Hans Konrad Müller-Hermelink & 

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© 1979 Plenum Press, New York

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Pearson, T.W., Roelants, G.E., Lundin, L.B., Mayor-Withey, K.S. (1979). Suppressor Cells in Trypanosoma Congolense-Infected Mice. In: Müller-Ruchholtz, W., Müller-Hermelink, H.K. (eds) Function and Structure of the Immune System. Advances in Experimental Medicine and Biology, vol 114. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9101-6_107

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  • DOI: https://doi.org/10.1007/978-1-4615-9101-6_107

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9103-0

  • Online ISBN: 978-1-4615-9101-6

  • eBook Packages: Springer Book Archive

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