Abstract
Up till now, leukocytes obtained from blood donations have been the main source of human interferon for clinical use. Production from these has been undertaken almost solely by Cantell and his colleagues in Finland, who have devised a highly efficient process (1). However, to make a large amount of this type of interferon entails that buffy coats are handled from many individual donors, which is laborious and expensive, and makes control relatively difficult. If interferon proves to be of value in even some of the clinical trials that are at present underway, then other sources will have to be found if the demand for interferon is to be met.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Cariteli K, Hirvonen S, Mogensen K E, et al. Human leukocyte interferon: Production, purification, stability, and animal experiments. The production and use of interferon for the treatment and prevention of human virus infections. Edited by C. Waymouth. Rockville, Tissue Culture Association, 1974, pp 35–38.
Havell E A, Vilcek J. Production of high titered interferon in cultures of human diploid cells. Antimicrob Agents Chemother 2: 476–484, 1972.
Billiau A, Joniau M, DeSomer P. Mass production of human interferon in diploid cells stimulated by poly I: C. J. Gen Virol 19: 1–8, 1973.
Havell E A, Berman B, Ogburn C A, et al. Two antigenically distinct species of human interferon. Proc Nat Acad Sci USA 72: 2185–2187, 1975
Einhorn S, Strander H. Is interferon tissue specific? - Effect of human leukocyte and fibroblast interferons on the growth of lymphoblastoid and osteosarcoma cell lines. J. Gen Virol 1977, in press.
Klein G, Dombos L, Gothoskar B. Sensitivity of Epstein-Barr virus (EBV) producer and non-producer human lymphoblastoid cell lines to superinfection with EB virus. Int J Cancer 10: 44–57, 1972.
Strander H, Mogensen K E, Cantell K. Production of human lymphoblastoid interferon. J Clin Microbiol 1: 116–117, 1975.
Christofinis G J.: Biological characteristics of the cell line GL - V3 derived from the kidney of a vervet moneky (Cercopithecus Aethiops). J Med Microbiol 3: 251–258, 1970.
Finter N B. Dye-uptake methods of assessing viral cytopatho- genicity and their application to interferon assays. J Gen Virol 5: 419–427, 1969.
Tan Y H, Berthold W.: A mechanism for the induction and regulation of human fibroblastoid interferon genetic expression. J Gen Virol 34: 401–411, 1977.
Tan Y H, Armstrong J A, Ke Y J, et al. Regulation of cellular interferon production: Enhancement by antimetabolites. Proc Nat Acad Sci USA 67: 464–471, 1970.
Vilcek J, Ng MH Post-transcriptional control of interferon synthesis. J Virol 7: 588–594, 1971.
Strander H, Cantell K. Production of interferon by human leukocytes in vitro. Ann Med Exp Biol Fenn 44: 265–273, 1966.
Strander H, Cantell K. Further studies on the production of interferon by human leukocytes in vitro. Ann Med Exp Biol Fenn 45: 20–29, 1967.
Tovell D, Cantell K. Kinetics of interferon production in human leukocyte suspensions. J Gen Virol 13: 485–489, 1971.
Hadbrazy G, Strander H, Cantell K. Serum requirement for interferon production by suspended human leukocytes: Studies on action of serum. J Gen Virol 5:: 351–358, 1969.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1978 Plenum Press, New York
About this chapter
Cite this chapter
Johnston, M.D., Fantes, K.H., Finter, N.B., Chir, B. (1978). Factors Influencing Production of Interferon by Human Lymphoblastoid Cells. In: Stinebring, W.R., Chapple, P.J. (eds) Human Interferon. Advances in Experimental Medicine and Biology, vol 110. Springer, New York, NY. https://doi.org/10.1007/978-1-4615-9080-4_6
Download citation
DOI: https://doi.org/10.1007/978-1-4615-9080-4_6
Published:
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4615-9082-8
Online ISBN: 978-1-4615-9080-4
eBook Packages: Springer Book Archive