Skip to main content

The Possibility of Interferon Production in Tumors

  • Chapter
  • First Online:
  • 52 Accesses

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 110))

Abstract

Endotoxin* injected into tumor bearing animals and humans may result in regression or even elimination of the tumor(1,2). Endotoxin alsc causes release of host products, including interferon(3), an antiviral factor which also has effects on tumor cell replication in vitro and in vivo in animals and possible humans(4), and tumor necrosing factor (TNF), which may be the basis for direct injury to the tumor(5).

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Gullino, P. M. 1966. The internal milieu of tumors. Prog. Exp. Tumor Res. 8: 1–25.

    Article  CAS  Google Scholar 

  2. Folkman, Judah. 1974. Tumor angiogenesis factor. Can. Res. 34: 2109.

    CAS  Google Scholar 

  3. Nauts, H. C. etal. 1946. The treatment of malignant tumors by bacterial toxins as developed by the late William B. Coley, M.D., reviewed in the light of modern research. Can. Res. 6: 205.

    Google Scholar 

  4. Nauts, H. C. 1973. Enhancement of natural resistance to renal cancer: Beneficial effects of concurrent infections and immunotherapy with bacterial vaccines. N.Y. Can. Res. Inst. Monograph #12.

    Google Scholar 

  5. Anon. 1934. Erysipelas and prodigiosus toxins (Coley). Reports of the Council. Council on Pharmacy and Chemistry. J.A.M.A. 103: 1067.

    Google Scholar 

  6. Stinebring, W. R. and D. Stevens. 1977. Escherichia coli endotoxin effect on a methylcholanthrene-induced sarcoma in the hamster cheekpouch. Proc. Soc. Exptl. Biol. Med. 156: 229.

    Article  CAS  Google Scholar 

  7. Evans, H. M. 1908. On the occurrence of newly-formed lymphatic vessels in malignant growths. Johns Hopkins Hospital Bulletin 209: 232.

    Google Scholar 

  8. Zeidman, I. et al. 1955. Experimental studies on the spread of cancer in the lymphatic supply in carcinoma. Cancer 8: 123.

    Article  CAS  Google Scholar 

  9. Alexander, P. etal. 1976. The significance of macrophages in human and experimental tumors. Ann. N.Y. Acad. Sci. 276: 124.

    Article  CAS  Google Scholar 

  10. Stinebring, W. R. and J. S. Youngner. 1964. Patterns of interferon appearance in mice injected with bacteria or bacterial endotoxin. Nature 204: 712.

    Article  CAS  Google Scholar 

  11. Carswell, E. A. etal. 1975. An endotoxin-induced serum factor that causes necrosis of tumors. Proc. Nat. Acad. Sc. ( USA ) 72: 3666.

    Article  CAS  Google Scholar 

  12. Stevens, D. A. and T. C. Merigan. 1972. Interferon, antibody, and other host factors in herpes zoster. J. Clin. Invest. 51: 1170.

    Article  CAS  Google Scholar 

  13. Hallum, J.V., H. R. Thacore and J. S. Youngner. 1972. Effect of exogenous interferon and L cells persistently infected with Newcastle Disease Virus. Infect. Imm. 5: 145.

    CAS  Google Scholar 

  14. See this volume.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1978 Plenum Press, New York

About this chapter

Cite this chapter

Stinebring, W.R., Jenkins, S. (1978). The Possibility of Interferon Production in Tumors. In: Stinebring, W.R., Chapple, P.J. (eds) Human Interferon. Advances in Experimental Medicine and Biology, vol 110. Springer, New York, NY. https://doi.org/10.1007/978-1-4615-9080-4_15

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-9080-4_15

  • Published:

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4615-9082-8

  • Online ISBN: 978-1-4615-9080-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics