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The Effects of Amphiphilic Compounds on Phosphatidate Metabolism

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Enzymes of Lipid Metabolism

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 101))

Summary

Amphiphilic cations interact with phosphatidate and thereby change its physical properties. This interaction can redirect phospholipid metabolism. In the presence of Mg2+ amphiphilic cations inhibit the activity of phosphatidate phosphohydrolase and stimulate that of phosphatidate cytidylyltransferase. Increasing the concentration of Mg2+ further or adding Ca2+ have similar effects, except that Ca2+ does not stimulate phosphatidate cytidylyltransferase activity. Amphiphilic anions reverse the effects caused by the amphiphilic cations. The implication of these results are discussed in relation to the pharmacological effects of amphiphilic cationic drugs.

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Authors and Affiliations

  1. Department of Biochemistry, University Hospital and Medical School, Nottingham, NG7 2UH, UK

    David N. Brindley, Mariana Bowley, R. Graham Sturton, P. Haydn Pritchard, June Cooling & Susan L. Burditt

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  1. David N. Brindley
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  2. Mariana Bowley
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  3. R. Graham Sturton
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  4. P. Haydn Pritchard
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  5. June Cooling
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  6. Susan L. Burditt
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Editor information

Editors and Affiliations

  1. Department of Biochemistry, The Hebrew University, Hadassah Medical School, P.O. Box 1172, Jerusalem, Israel

    Shimon Gatt

  2. C.N.R.S. Center for Neurochemistry, Louis Pasteur University, 11 rue Humann, 67085, Strasbourg Cedex, France

    Louis Freysz  & Paul Mandel  & 

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© 1978 Plenum Press, New York

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Brindley, D.N., Bowley, M., Sturton, R.G., Pritchard, P.H., Cooling, J., Burditt, S.L. (1978). The Effects of Amphiphilic Compounds on Phosphatidate Metabolism. In: Gatt, S., Freysz, L., Mandel, P. (eds) Enzymes of Lipid Metabolism. Advances in Experimental Medicine and Biology, vol 101. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9071-2_22

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  • DOI: https://doi.org/10.1007/978-1-4615-9071-2_22

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9073-6

  • Online ISBN: 978-1-4615-9071-2

  • eBook Packages: Springer Book Archive

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