Abstract
Eight rats drank large amounts of 6.25% alcohol as a consequence of daily exposure to 6 hours of schedule-induction sessions in “which a small food pellet was delivered every 90 sec. Rats having a 1-hr session every 4 hr showed slightly more withdrawal distress than rats having a 6-hr session every 24 hr. More significant may have been two different kinds of indication of possible loss of control over drinking by the inducing schedule. Rats experiencing six sessions a day did not drink water excessively when it replaced the alcohol solution. Rats experiencing one session a day drank half their total alcohol intake between sessions. If the schedule-induction procedure loses control over alcohol drinking, its chronic application to animals fails as a model of the factors that maintain excessive alcohol use in humans.
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Gilbert, R.M. (1977). Chronic Alcohol Drinking and Subsequent Withdrawal in Rats Exposed to Different Diurnal Distributions of Schedule-Induction Sessions. In: Gross, M.M. (eds) Alcohol Intoxication and Withdrawal—IIIb. Advances in Experimental Medicine and Biology, vol 85B. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9038-5_32
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