Advertisement

The Effects of Sodium Phenobarbital on Voluntary Ethanol Consumption in Rats

  • D. B. Rondeau
  • M. J. Wayner
  • F. B. Jolicoeur
  • L. P. Dwoskin
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 85B)

Abstract

The barbiturates, among other sedatives, have been studied in alcohol research primarily in the alleviation of the withdrawal reaction in animals (2) and humans (14). However, barbiturates are dip-sogenic agents and have not been studied thoroughly in relation to consumption of ethanol or alcoholic beverages.

Keywords

Ethanol Solution Chronic Administration Ethanol Consumption Ethanol Intake Percent Intake 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Falk, J. L. and Burnidge, G. K. Fluid intake and punishment-attenuating drugs. Physiol. Behav. 5: 199–202, 1970.Google Scholar
  2. 2.
    Goldstein, D. B. An animal model for testing effects of drugs on alcohol withdrawal reactions. J. Pharmacol, exp. Ther. 183: 14–22, 1972.Google Scholar
  3. 3.
    Kachanoff, R. The effect of phénobarbital and chlordiazepoxide on water and alcohol intake. Unpublished doctoral dissertation, Arizona State University, 1969.Google Scholar
  4. 4.
    Maickel, R. P. and Maloney, G. J. Effects of various depressant drugs on deprivation-induced water consumption. Neuropharmac. 12: 777–782, 1973.CrossRefGoogle Scholar
  5. 5.
    Myers, R. D. Voluntary alcohol consumption in animals: Peripheral and intracerebral factors. Psychosom. Med. 28: 484–497, 1966.Google Scholar
  6. 6.
    Richter, C. P. and Campbell, K. H. Alcohol taste thresholds and concentrations of solutions preferred by rats. Science 91: 507–508, 1940.CrossRefGoogle Scholar
  7. 7.
    Rondeau, D. B., Wayner, M. J. and Jolicoeur, F. B. Modification of ethanol preference in the rat by chronic administration of phenobarbital. Paper presented at Medical-Scientific Conference of National Council of Alcoholism, Washington, D.C., May 6–8, 1976.Google Scholar
  8. 8.
    Rondeau, D. B., Jolicoeur, F. B., Kachanoff, R., Scherzer, P. and Wayner, M. J. Effects of phenobarbital on ethanol intake in fluid deprived rats. Pharmac. Biochem. Behav. 3: 493–497, 1975.CrossRefGoogle Scholar
  9. 9.
    Schmidt, H., Jr. Water intake as an index of drug action. In M. J. Wayner (Ed.) Thirst in the Regulation of Body Water, pp. 185–209. Oxford: Pergamon Press, 1964.Google Scholar
  10. 10.
    Schmidt, H., Jr. Variations in water ingestion: The response to barbiturates. In W. A. Himwich and J. P. Schade (Eds.) Progress in Brain Research, Vol. 16, Horizons in Neuropsychopharmacology, pp. 263–284. Amsterdam: Elsevier, 1965.Google Scholar
  11. 11.
    Schmidt, H., Jr. Barbiturate effects on saline acceptance and post-ingestion variables. Physiol. Behav. 1: 183–189, 1966.CrossRefGoogle Scholar
  12. 12.
    Schmidt, H., Jr. and Dry, L. Dose and time as variables in barbiturate action upon water ingestion. Amer. J. Physiol. 204: 817–820, 1963.Google Scholar
  13. 13.
    Schmidt, H., Jr. and Moak, S. J. Some drug effects in Influencing barbiturate facilitation of water ingestion. Amer. J. Physiol. 196: 307–310, 1959.Google Scholar
  14. 14.
    Sellers, E. M. and Kalant, H. Drug therapy: Alcohol intoxication and withdrawal. New England J. Med. 294: 757–762, 1976.CrossRefGoogle Scholar
  15. 15.
    Wayner, M. J., Jolicoeur, F. B., Rondeau, D. B. and Merkel, A. D. The effects of sodium phenobarbital on forced and voluntary alcohol consumption in the rat. In J. D. Sinclair and K. Kiianmaa (Eds.) The Effects of Centrally Active Drugs on Voluntary Alcohol Consumption, Vol. 24, pp. 35–48. Helsinki: The Finnish Foundation for Alcohol Studies, 1975.Google Scholar
  16. 16.
    Wayner, M. J., Rondeau, D. B., Jolicoeur, F. B. and Wayner, E. A. Effects of phenobarbital on saccharin and citric acid intake in fluid deprived rats. Pharmac. Biochem. Behav. 4: 335–337, 1976.CrossRefGoogle Scholar
  17. 17.
    Wayner, M. J., Greenberg, I., Tartaglione, R., Nolley, D., Fraley, S. and Cott A. A new factor affecting the consumption of ethyl alcohol and other sapid fluids. Physiol. Behav. 8: 345–362, 1972.CrossRefGoogle Scholar
  18. 18.
    Wallgren, H. and Barry, H., III, Actions of Alcohol, Vol. II; Chronic and Clinical Aspects, pp. 403–477. Amsterdam: Elsevier, 1970.Google Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • D. B. Rondeau
    • 1
  • M. J. Wayner
    • 1
  • F. B. Jolicoeur
    • 1
  • L. P. Dwoskin
    • 1
  1. 1.Brain Research LaboratorySyracuse UniversitySyracuseUSA

Personalised recommendations