Skip to main content
SpringerLink
Log in
Book cover

Explorations in Aging pp 21–37Cite as

Age Dependent Decline in Proliferation of Lymphocytes

  • Chapter
  • First Online:

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 61))

Abstract

Only during the past twenty years have attempts been made to carefully and systematically document declining function of the immunologic system with age. It is now known that senescence of the immunologic system occurs in all mammalian species studied, as measured by a variety of immunologic indices. Thus, amongst most but not all of the cellular components constituting the immune system, age dependent deficits in proliferation, differentiation and function have been found. For example, mitogenic responses of lymphocytes, ability of stem cells to reconstitute irradiated hosts, recognition of threshold doses of antigen, and maximum humoral antibody responses are all decreased with aging (Heidrick and Hakinodan, 1972a; Ram, 1967; Lajtha and Schofield, 1971). The consequences of this immunologic decline are very important to the organism and have been implicated in increased susceptibility of old animals to a variety of infectious insults and the increased incidence of neoplasia. General theories of aging have been postulated linking this decline in immunity, and an associated rise of autoimmunity, with most of the diseases attributed to the aging process including cancer and atherosclerosis (Walford, 1969, Robert and Robert, 1973). Since aging influences the differentiation and proliferation potential of immunologic cells, the immune system is an ideal model for the study of aging at the cellular level. Compelling reasons for this view are listed in Table I.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Adler, W. H., T. Takiguchi, and R. T. Smith. J. Immunol. 107: 1357 (1971).

    CAS  PubMed  Google Scholar 

  2. Bach, J. F., M. Dardenne, and J. C. Salomon. Clin. Exp. Immunol. 14: 247 (1973).

    CAS  PubMed  PubMed Central  Google Scholar 

  3. Baer, H., and R. T. Bowser. Science 140: 1211 (1963).

    Article  CAS  Google Scholar 

  4. Bellamy, D. Gerontologia 19: 162.

    Google Scholar 

  5. Buckley, C. E., and F. C. Dorsey. Ann. Int. Med. 75: 673 (1971).

    Article  CAS  Google Scholar 

  6. Chen, M. G. J. Cell. Physiol. 78: 225 (1971).

    Article  CAS  Google Scholar 

  7. Coggle, J. E., and C. Proukakis. Gerontologia, 16: 25 (1970).

    Article  CAS  Google Scholar 

  8. Dauphinee, M. J., N. Talal, A. L. Goldstein, and A. White. Proc. Nat. Acad. Sci. USA 71: 2637 (1974).

    Article  CAS  Google Scholar 

  9. Davenport, F. M., A. V. Hennessy, and T. Francis. J. Exp. Med. 98: 641 (1953).

    Article  CAS  Google Scholar 

  10. Davis, M. L., A. C. Upton, and L. C. Satterfield. Proc. Soc. Exp. Biol. Med. 137: 1452 (1971).

    Article  CAS  Google Scholar 

  11. Farrar, J. J., B. E. Loughman, and A. A. Nordin. J. Immunol. 112: 1244 (1974).

    CAS  PubMed  Google Scholar 

  12. Gross, L. Cancer 18: 201 (1965).

    Article  CAS  Google Scholar 

  13. Groves, D. L., W. E. Lever, and T. Makinodan. J. Immunol. 104: 148 (1970).

    CAS  PubMed  Google Scholar 

  14. Haferkamp, O., D. Schlettwein-Gsell, H. G. Schwick, and K. Storiko. Gerontologia 12: 30 (1966).

    Article  CAS  Google Scholar 

  15. Hallgren, H. M., C. E. Buckley, V. A. Gilbersten, and E. J. Yunis. J. Immunol. 111: 1101 (1973).

    CAS  PubMed  Google Scholar 

  16. Halsall, M. H., M. L. Heidriclc, J. W. Deitchman, and T. Makinodan. Gerontologist 13, No. 3, Part 11: 46 (1973).

    Google Scholar 

  17. Hammar, J. A. Endocrinology 5:543 and 731 (1921).

    Article  Google Scholar 

  18. Harrison, D. E. Proc. Nat. Acad. Sci. USA 70: 3184 (1973).

    Article  CAS  Google Scholar 

  19. Heidrick, M. L. and T. Makinodan. Gerontologia 18: 305 (1972a).

    Article  CAS  Google Scholar 

  20. Heidrick, M. L. Gerontologist 12, No. 3, Part 11: 28 (1972b).

    Google Scholar 

  21. Heidrick, M. L. and T. Makinodan. J. Immunol. 111: 1502 (1973a).

    CAS  PubMed  Google Scholar 

  22. Heidrick, M. L. J. Cell Biol. 59, No. 2, Part 2: 139a (1973b).

    Google Scholar 

  23. Hirokawa, K., and T. Makinodan. Gerontologist 14, No. 5, Part 11: 33 (1974).

    Google Scholar 

  24. Hoffman, M. Immunol. 18: 791 (1970).

    Google Scholar 

  25. Hori, Y., E. H. Perkins, and M. K. Halsall. Proc. Soc. Exp. Biol. Med. 144: 48 (1973).

    Article  CAS  Google Scholar 

  26. Immunology of aging workshop, 1974, The second international congress of immunology, Brighton, Sussex, England, Proceeding in press, Plenum Press, London.

    Google Scholar 

  27. Jeejeeboy, H. F. Transplantation 12: 525 (1971).

    Article  Google Scholar 

  28. Kishimoto, S., I. Tsuyuguchi, and Y. Yamamura. Clin. Exp. Immunol.. 5: 525 (1969).

    CAS  PubMed  PubMed Central  Google Scholar 

  29. Lajtha, L. G., and R. Schofield. Adv. Geron. Res. 3: 131 (1971).

    CAS  Google Scholar 

  30. Makinodan, T., and W. J. Peterson. Developmental Biol. 14: 96 (1966).

    Article  CAS  Google Scholar 

  31. Makinodan, T., F. Chino, W. F. Lever, and B. S. Brewen. J. Geront. 26: 515 (1971).

    Article  CAS  Google Scholar 

  32. Makinodan, T., and W. H. Adler. Fed. Proc. In press.

    Google Scholar 

  33. Mathies, M., L. Lipps, G. S. Smith, and R. L. Walford. J. Gerontol. 28: 425 (1973).

    Article  CAS  Google Scholar 

  34. Metcalf, D. Cancer Res. 24: 1952 (1964).

    CAS  PubMed  Google Scholar 

  35. Metcalf, D., R. Moulds, and B. Pike. Clin. Exp. Immunol. 2: 109 (1966).

    Google Scholar 

  36. Micklem, H. S., C. E. Ford, E. P. Evans, and J. Gray. Proc. Roy. Soc. (Biol.)165: 78 (1966).

    CAS  Google Scholar 

  37. Mosier, D. E., and L. W. Coppleson. Proc. Nat. Acad. Sci. 61: 542 (1968).

    Article  CAS  Google Scholar 

  38. Perkins, E. H. J. Reticol. Soc. 9: 642 (1971).

    Google Scholar 

  39. Price, G. B., and T. Makinodan. J. Immunol. 108: 403 (1972a).

    CAS  PubMed  Google Scholar 

  40. Price, G. B., and T. Makinodan. J. Immunol. 108: 413 (1972b).

    CAS  PubMed  Google Scholar 

  41. Ram, J. J. Gerontol. 22: 92 (1967).

    CAS  PubMed  Google Scholar 

  42. Robert, L., and B. Robert. Gerontologia 19: 330 (1973).

    Article  CAS  Google Scholar 

  43. Rowley, M. J., H. Buchanan, and I. R. Mackay. Lancet 2: 24 (1968).

    Article  CAS  Google Scholar 

  44. Solomonova, K., and St. Vizev. Zeitschrift Immunitatsforschung 146: 81 (1973).

    CAS  Google Scholar 

  45. Somers, H., and W. J. Kuhns. Proc. Soc. Exp. Biol. Med. 141: 1104 (1972).

    Article  CAS  Google Scholar 

  46. Stutman, O. J. Immunol. 109: 602 (1972).

    CAS  PubMed  Google Scholar 

  47. Thomsen, O., and K. Kettel. Zeitschrift Immunitatsforschung 63: 67 (1929).

    CAS  Google Scholar 

  48. Toya, R. E., and M. L. Davis. Biomedicine 19: 244 (1973).

    CAS  PubMed  Google Scholar 

  49. Walford, R. L. In: The Immunologic Theory of Aging, Williams and Wilkins, Baltimore, Md. (1969).

    Chapter  Google Scholar 

  50. Wigzell, H., and J. Stjernsward. J. Nat. Can. Inst. 37: 513 (1966).

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratory of Cellular and Comparative Physiology, Gerontology Research Center, National Institute of Child Health & Human Development, NIH, PHS, HEW, Bethesda, USA

    Gordon Stoltzner & Takashi Makinodan

  2. Baltimore City Hospitals, Baltimore, MD, 21224, USA

    Gordon Stoltzner & Takashi Makinodan

Authors
  1. Gordon Stoltzner
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Takashi Makinodan
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania, USA

    Vincent J. Cristofalo

  2. Medical College of Pennsylvania, Philadelphia, Pennsylvania, USA

    Jay Roberts

  3. Fels Research Institute, Temple University School of Medicine, Philadelphia, Pennsylvania, USA

    Richard C. Adelman

Rights and permissions

Reprints and permissions

Copyright information

© 1975 Plenum Press, New York

About this chapter

Cite this chapter

Stoltzner, G., Makinodan, T. (1975). Age Dependent Decline in Proliferation of Lymphocytes. In: Cristofalo, V.J., Roberts, J., Adelman, R.C. (eds) Explorations in Aging. Advances in Experimental Medicine and Biology, vol 61. Springer, New York, NY. https://doi.org/10.1007/978-1-4615-9032-3_2

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-9032-3_2

  • Published:

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4615-9034-7

  • Online ISBN: 978-1-4615-9032-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation