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Comparison of the Induction Course, Biophysical Chemical Interactions and Photochemical Action Spectra of Phenobarbital and 3-Methylcholanthrene Induced Hepatic Microsomal P-450

  • D. Y. Cooper
  • H. Schleyer
  • J. H. Thomas
  • H. M. Vars
  • O. Rosenthal
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 58)

Abstract

That the P-450-dependent microsomal mixed function oxidase systems induced in rat livers by polycyclic hydrocarbons (3-methyl-cholanthrene (3-MC)) are different from those induced by phenobarbital (PB) was first reported by Sladek and Mannering (1966). More recently Fouts (1973) has observed that 3-MC is much less effective than phenobarbital in inducing the microsomal electron transport system necessary for reduction of P-450. It is likely, therefore, that during the course of induction of enzyme activity with polycyclic hydrocarbons and the decline of this activity to preinduc-tion levels there would be not only differences in the type of P-450 from that in PB-induced animals, but also changes in the reductive capacity of the microsomal electron transport system.

Keywords

Spectral Change Difference Spectrum Action Spectrum Polycyclic Hydrocarbon Demethylase Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1975

Authors and Affiliations

  • D. Y. Cooper
    • 1
  • H. Schleyer
    • 1
  • J. H. Thomas
    • 1
  • H. M. Vars
    • 1
  • O. Rosenthal
    • 1
  1. 1.Harrison Department of Surgical Research and Johnson Research Foundation, School of MedicineUniversity of PennsylvaniaPhiladelphiaUSA

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