Abstract
That the P-450-dependent microsomal mixed function oxidase systems induced in rat livers by polycyclic hydrocarbons (3-methyl-cholanthrene (3-MC)) are different from those induced by phenobarbital (PB) was first reported by Sladek and Mannering (1966). More recently Fouts (1973) has observed that 3-MC is much less effective than phenobarbital in inducing the microsomal electron transport system necessary for reduction of P-450. It is likely, therefore, that during the course of induction of enzyme activity with polycyclic hydrocarbons and the decline of this activity to preinduc-tion levels there would be not only differences in the type of P-450 from that in PB-induced animals, but also changes in the reductive capacity of the microsomal electron transport system.
Dr. Cooper is the recipient of Research Development Award 5 KO3 HL 25132
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Cooper, D.Y., Schleyer, H., Thomas, J.H., Vars, H.M., Rosenthal, O. (1975). Comparison of the Induction Course, Biophysical Chemical Interactions and Photochemical Action Spectra of Phenobarbital and 3-Methylcholanthrene Induced Hepatic Microsomal P-450. In: Cooper, D.Y., Rosenthal, O., Snyder, R., Witmer, C. (eds) Cytochromes P-450 and b5 . Advances in Experimental Medicine and Biology, vol 58. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9026-2_6
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