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Dissociation of Microsomal Ethanol Oxidation from Cytochrome P-450 Catalyzed Drug Metabolism

  • Kostas P. Vatsis
  • Martin P. Schulman
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 58)

Abstract

Considerable evidence is currently available which strongly suggests that, in addition to the alcohol dehydrogenase (ADH)-catalyzed reaction, a pyrazole-insensitive pathway participates in the metabolism of ethanol in vivo (Israel et al., 1970; Lieber and DeCarli, 1972), in the isolated perfused rat liver (Papenberg et al., 1970; Thurman and McKenna, 1974), in rat and mouse liver slices (Thieden, 1971; Lieber and DeCarli, 1970; Vatsis and Schulman, 1973a; Vatsis et al., 1973), and in isolated rat liver parenchymal cells (Grunnet et al., 1973). The non-ADH pathway has two distinguishing properties, namely, it becomes increasingly important at ethanol concentrations (20–80 mM) well above the Km of AHD (Thieden, 1971; Vatsis et al., 1973; Lieber and DeCarli, 1973), and appears to be inducible by chronic ethanol feeding (Lieber and DeCarli, 1970, 1972) as well as by treatment of animals with phenobarbital (Carter and Isselbacher, 1971; Khanna et al., 1972; Vatsis and Schulman, 1974).

Keywords

NADPH Oxidase Catalase Activity Liver Microsome Liver Slice Ethanol Oxidation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1975

Authors and Affiliations

  • Kostas P. Vatsis
    • 1
  • Martin P. Schulman
    • 1
  1. 1.Department of Pharmacology, School of Basic Medical SciencesUniversity of Illinois College of MedicineChicagoUSA

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