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Discussion

  • David Y. Cooper
  • Otto Rosenthal
  • Robert Snyder
  • Charlotte Witmer
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 58)

Abstract

I would like to address a question to Dr. Hutterer concerning the effect of cyclic AMP. What has interested me about this is that the original observations on the effect of this agent suggested that it only acts on intact cells. I was wondering whether this could be comparable to the suppression of the synthesis of cytochrome P-450 produced by high carbohydrate diets. The added cyclic AMP produces a high concentration of glucose in the hepatocyte by the well-known mechanisms of the late Dr. Sutherland and may well explain the results you are seeing here.

Keywords

Action Spectrum Hydroxylase Activity High Carbohydrate Diet Styrene Oxide Aryl Hydrocarbon Hydroxylase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1975

Authors and Affiliations

  • David Y. Cooper
    • 1
  • Otto Rosenthal
    • 1
  • Robert Snyder
    • 2
  • Charlotte Witmer
    • 2
  1. 1.Harrison Department of Surgical ResearchUniversity of Pennsylvania School of MedicinePhiladelphiaUSA
  2. 2.Department of PharmacologyThomas Jefferson UniversityPhiladelphiaUSA

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