Abstract
Although changes in extracellular K+ activity (aK) have long been suspected in mechanisms of function and dysfunction in the central nervous system (Dubner & Gerard, 1939; Grafstein, 1956; Kuffler, 1967), only recently has it become practicable to record them both directly and with precise localization (Hinke, 1961; Walker, 1971). We have used micro-electrodes containing a liquid ion-exchanger (Walker, 1971) to measure extracellular aK in the cerebral cortex, and also in regions of the spinal cord and the medulla which receive the terminals of somato-sensory nerve fibres (Krnjevic & Morris, 1972).
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References
AMES, A., III, HIGASHI, K. and NESBETT, FRANCES B. 1965. Relation of potassium concentration in choroid-plexus fluid to that in plasma. J. Physiol. 181, 506–515.
BARRON, D. H., and MATTHEWS, B. H. C. 1938. The interpretation of potential changes in the spinal cord. J. Physiol. 92, 276–321.
COOKE, J. D. and QUASTEL, D. M. J. 1973. The specific effect of potassium on transmitter release by motor nerve terminals and its inhibition by calcium. J. Physiol. 228, 435–458.
DUBNER, H. H. and GERARD, R. W. 1939. Factors controlling brain potentials in the cat. J. Neurophysiol. 2, 142–152.
ECCLES, J. C. 1964. The Physiology of Synapses. Springer-Verlag; Berlin, Germany, p.316.
FAM, W. M., NAKHJAVAN, F. K., SEKELY, P. and McGREGOR, M. 1966. Proc. Int. Symp. Cardiovasc. & Respir. Effects of Hypoxia, Kingston, Ont. 1965, pp. 375–390.
GRAFSTEIN, B. 1956. Mechanism of spreading cortical depression. J. Neurophysiol. 19, 154–171.
HINKE, J. A. M. 1961. The measurement of sodium and potassium activities in the squid axon by means of cation-selective glass micro-electrodes. J. Physiol. 156, 314–335.
KRNJEVIĆ, K. and MORRIS, M. E. 1972, Extracellular K+ activity and slow potential changes in spinal cord and medulla. Can. J. Physiol. Pharmacol. 50, 1214–1217.
KRNJEVIĆ, K., RANDIĆ, M. and STRAUGHAN, D. W. 1966. An inhibitor; process in the cerebral cortex. J. Physiol. 184, 16–48.
KRNJEVIĆ, K. and SCHWARTZ, S. 1967. The action of γ-aminobutyric acid on cortical neurones. Expl. Brain Res. 3, 320–336.
KUFFLER, S. W. 1967. Neuroglial cells: Physiological properties and a potassium mediated effect of neuronal activity on the glial membrane potential. Proc. Roy. Soc. Ser. B 168, 1–21.
MARSHALL, W. H. 1959. Spreading cortical depression of Leão. Physiol. Rev. 39, 239–279.
MORRIS, M. E. 1974. Hypoxia and extracellular potassium activity in the guinea-pig cortex. Can. J. Physiol. Pharmacol. 52 (in press)
VYSKOČil, F., KŘÍž, N., and BUREŠ, J. 1972. Potassium-selective microelectrodes used for measuring the extracellular brain potassium during spreading depression and anoxic depolarization in rats. Brain Research 39, 255–259.
WALKER, J. L. 1971. Ion specific liquid ion exchanger micro-electrodes. Analyt. Chem. 43, 89A–93A.
WALL, P. D. 1958. Excitability changes in afferent fibre terminations and their relation to slow potentials. J. Physiol. 218, 671–689.
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© 1974 Plenum Press, New York
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Morris, M.E., Krnjević, K. (1974). Some Measurements of Extracellular Potassium Activity in the Mammalian Central Nervous System. In: Berman, H.J., Hebert, N.C. (eds) Ion-Selective Microelectrodes. Advances in Experimental Medicine and Biology, vol 50. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9023-1_10
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DOI: https://doi.org/10.1007/978-1-4615-9023-1_10
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