Regional Changes in Intramyocardial Pressure Following Myocardial Ischemia
Previous studies from this laboratory have demonstrated the presence of regional abnormalities in myocardial blood flow during ischemia (1). The finding of relative subendocardial ischemia following coronary artery occlusion is thought to be due to a decrease in the diastolic coronary perfusion gradient (2). This gradient depends upon the relationship between the distal coronary artery perfusion pressure and left ventricular end diastolic pressure. The present study was undertaken to determine whether delayed relaxation might also occur following myocardial ischemia and thereby further compromise the effect of diastolic coronary perfusion gradient.
KeywordsCoronary Artery Myocardial Blood Flow Left Ventricular Cavity Circumflex Coronary Artery Left Circumflex Coronary Artery
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