Coronary and Systemic Hemodynamics in Chemically Sympathectomized Dogs
In order to examine the influence of the sympathetic innervation on coronary and systemic hemodynamics, dogs have been chemically sympathectomized by repeated administration of 6-hydroxydopamine i.v. This procedure results in a selective degeneration of peripheral nerve endings (8). In adult animals the adrenal medulla remains unaffected, but may show compensatory hyperactivity (6). Since in the adult animal the sympathetic ganglionic cells and axons remain intact, regeneration of sympathetic nerve endings takes place within a few weeks (4). This technique allows one to obtain data before and after sympathectomy in the same animal within a short period of time and without the additional trauma and complications due to surgical denervation.
KeywordsArterial Pressure Coronary Flow Peripheral Resistance Moderate Exercise Systemic Hemodynamic
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