Advertisement

The Effect of Glyceryl Trinitrate on Coronary Collateral Flow — A Preliminary Report

  • Edward M. Khouri
  • Agustin R. Iza
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 39)

Abstract

There are many reports in the literature of the action of glyceryl trinitrate (GTN) on the coronary circulation. The effects have been studied on both the natural and the collateral circulation, using such techniques as direct flow measurement (1), radioisotope clearance (2), retrograde flow (3), peripheral pressure (4), pressure gradient (5), etc.; and there are as many explanations of the mode of action of the drug. This is a preliminary reports on the effects of GTN on the pre-existing coronary collateral vessels in the open chest dog. A beta ray detector affixed to the epicardial surface was used to obtain washout curves of 85Kr.

Keywords

Myocardial Blood Flow Collateral Flow Left Coronary Artery Coronary Collateral Clearance Curve 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Khouri, E.M., Gregg, D.E., and Lowensohn, H.S.: Flow in the major branches of the left coronary artery during experimental coronary insufficiency in the unanesthetized dog. Circ. Res. 23:99, 1968.PubMedCrossRefGoogle Scholar
  2. 2.
    Rees, R. J., Redding, V. J., Ashfield, R., Gibson, D., and Gavey, C.J.: Myocardial blood flow measurements with 133Xe Effect of glyceryl trinitrate in dogs. Brit. Heart J. 28:374, 1966.PubMedCrossRefGoogle Scholar
  3. 3.
    Leighinger, D.S., Rueger, R., and Beck, C.S.: Effect of glyceryl trinitrate (nitroglycerin) on arterial blood supply to ischemic myocardium. Am. J. Cardiol. 3:638, 1959.CrossRefGoogle Scholar
  4. 4.
    Pasyk, S., Bloor, C.M., Khouri, E.M., and Gregg, D.E.: Systemic and coronary effects of coronary artery occlusion in the unanesthetized dog. Am. J. Physiol. 220:646, 1971.PubMedGoogle Scholar
  5. 5.
    McGregor, M., and Fam, W.M.: Regulation of coronary blood flow. Bull. N.Y. Acad. Med. 42:940, 1966.PubMedGoogle Scholar
  6. 6.
    Johnston, P.A., Huth, G.C., and Locker, R.J.: Low-energy radioactivity and avalanche semiconductor radiation detectors. Isotopes and Radiation Technology 7:266, 1970.Google Scholar
  7. 7.
    Herd, J.A., Hollenberg, M., Thorburn, G.D., Kopold, H.H., and Barger, A.C.: Myocardial blood flow determined with Krypton 85 in unanesthetized dogs. Am. J. Physiol. 203:122, 1962.PubMedGoogle Scholar
  8. 8.
    Linder, E.: Measurements of normal and collateral coronary blood flow by close-arterial and intramyocardial injection of 85Kr and 133Xe. Acta Physiol. Scand. 68(Suppl. 272):5, 1966.Google Scholar
  9. 9.
    Linder, E., and Seeman, T.: Effects of persantin and nitroglycerin on myocardial blood flow during temporary coronary occlusion in dogs. Angiologica 4:225, 1967.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1973

Authors and Affiliations

  • Edward M. Khouri
    • 1
  • Agustin R. Iza
    • 1
  1. 1.Department of Cardiorespiratory Diseases, Walter Reed Army Medical CenterWalter Reed Army Institute of ResearchUSA

Personalised recommendations