The Effect of Glyceryl Trinitrate on Coronary Collateral Flow — A Preliminary Report
There are many reports in the literature of the action of glyceryl trinitrate (GTN) on the coronary circulation. The effects have been studied on both the natural and the collateral circulation, using such techniques as direct flow measurement (1), radioisotope clearance (2), retrograde flow (3), peripheral pressure (4), pressure gradient (5), etc.; and there are as many explanations of the mode of action of the drug. This is a preliminary reports on the effects of GTN on the pre-existing coronary collateral vessels in the open chest dog. A beta ray detector affixed to the epicardial surface was used to obtain washout curves of 85Kr.
KeywordsMyocardial Blood Flow Collateral Flow Left Coronary Artery Coronary Collateral Clearance Curve
Unable to display preview. Download preview PDF.
- 6.Johnston, P.A., Huth, G.C., and Locker, R.J.: Low-energy radioactivity and avalanche semiconductor radiation detectors. Isotopes and Radiation Technology 7:266, 1970.Google Scholar
- 8.Linder, E.: Measurements of normal and collateral coronary blood flow by close-arterial and intramyocardial injection of 85Kr and 133Xe. Acta Physiol. Scand. 68(Suppl. 272):5, 1966.Google Scholar