The Effect of Glyceryl Trinitrate on Coronary Collateral Flow — A Preliminary Report

  • Edward M. Khouri
  • Agustin R. Iza
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 39)


There are many reports in the literature of the action of glyceryl trinitrate (GTN) on the coronary circulation. The effects have been studied on both the natural and the collateral circulation, using such techniques as direct flow measurement (1), radioisotope clearance (2), retrograde flow (3), peripheral pressure (4), pressure gradient (5), etc.; and there are as many explanations of the mode of action of the drug. This is a preliminary reports on the effects of GTN on the pre-existing coronary collateral vessels in the open chest dog. A beta ray detector affixed to the epicardial surface was used to obtain washout curves of 85Kr.


Myocardial Blood Flow Collateral Flow Left Coronary Artery Coronary Collateral Clearance Curve 
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Copyright information

© Plenum Press, New York 1973

Authors and Affiliations

  • Edward M. Khouri
    • 1
  • Agustin R. Iza
    • 1
  1. 1.Department of Cardiorespiratory Diseases, Walter Reed Army Medical CenterWalter Reed Army Institute of ResearchUSA

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