Hemodynamic Evidence of the Development of Coronary Collateral Circulation in Conscious Dogs

  • Eric C. Elliot
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 39)


Since 1964, we have addressed ourselves to the problem of the rate of development of collateral circulation following coronary occlusion in the conscious dog preparation. Four different experimental approaches have been used, all of which have essentially involved the effects of gradual circumflex branch occlusion on collateral development. An attempt will be made to summarize the earlier experiments and to give in more detail the salient features of more recent experiments.


Coronary Occlusion Reactive Hyperemia Collateral Blood Flow Electromagnetic Flowmeter Coronary Pressure 
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  1. 1.
    Anrep, G.V. and H. Häusler. The Coronary Circulation. 1. The effect of changes of the blood-pressure and of the output of the heart. J. Physiol. 65:357–373, 1928.PubMedGoogle Scholar
  2. 2.
    Mautz, F.R. and D.E. Gregg. Dynamics of collateral circulation following chronic occlusion of coronary arteries. Proc. Soc. Exp. Biol. Med. 36: 797–801, 1937.Google Scholar
  3. 3.
    Eckstein, R.W., D.E. Gregg, and W.H. Pritchard. The magnitude and time of development of the collateral circulation in occluded femoral, carotid and coronary arteries. Am. J. Physiol. 132:351–361, 1941.Google Scholar
  4. 4.
    Herd, J.A. and A.C. Barger. Simplified technique for chronic catheterization of blood vessels. J. Appl. Physiol. 19:791–792, 1964.PubMedGoogle Scholar
  5. 5.
    Elliot, E.C., E.L. Jones, C.M. Bloor, A.S. Leon, and D.E. Gregg. Day-to-day changes in coronary hemodynamics secondary to constriction of circumflex branch of left coronary artery in conscious dogs. Circ. Res. 22:237–250, 1968.PubMedCrossRefGoogle Scholar
  6. 6.
    Elliot, E.C., C.M. Bloor, E.L. Jones, W.J. Mitchell and D.E. Gregg. Effect of controlled coronary occlusion on collateral circulation in conscious dogs. Am. J. Physiol. 220:857–861, 1971.PubMedGoogle Scholar
  7. 7.
    Khouri, E.M., D.E. Gregg and H.S. Lowensohn. Flow in the major branches of the left coronary artery during experimental coronary insufficiency in the unanesthetized dog. Circ. Res. 23: 99–109, 1968.PubMedCrossRefGoogle Scholar
  8. 8.
    Herd, J.A., M. Hollenberg, C.D. Thorburn, H.H. Kopald and A.C. Barger. Myocardial blood flow determined with krypton 85 in unanesthetized dogs. Am. J. Physiol. 203:122–124, 1962.PubMedGoogle Scholar
  9. 9.
    Johansson, B., E. Linder and T. Seeman. Collateral blood flow in the myocardium of dogs measured with Krypton85. Acta Physiol. Scand. 62:263–270, 1964.PubMedCrossRefGoogle Scholar
  10. 10.
    Ross, R.S., K. Ueda, P.R. Lichtlen and J.R. Rees. Measurement of myocardial blood flow in animals and man by selective injection of radioactive inert gas into the coronary arteries. Circ. Res. 15:28–41, 1964.PubMedCrossRefGoogle Scholar
  11. 11.
    Chimoskey, J.E., M. Szentvanyi, R. Zakheim and A.C. Barger. Temporary coronary occlusion in conscious dogs: collateral flow and electrocardiogram. Am. J. Physiol. 212:1025–1032, 1967.PubMedGoogle Scholar
  12. 12.
    Rees, J.R. and V.J. Redding. Anastomotic blood flow in experimental myocardial infarction. A new method, using 133 Xenon clearance, for repeated measurements during recovery. Cardiovasc. Res. 1:169–178, 1967.PubMedCrossRefGoogle Scholar
  13. 13.
    Haft, J.I. and A.N. Damato. Measurement of collateral blood flow after myocardial infarction in the closed-chest dog. Am. Heart J. 77:641–648, 1969.PubMedCrossRefGoogle Scholar
  14. 14.
    Eckstein, R.W. Effect of exercise and coronary artery narrowing on coronary collateral circulation. Circ. Res. 5:230–235, 1957.PubMedCrossRefGoogle Scholar
  15. 15.
    Berne, R.M., R.D. Jones and F.S. Cross. Evaluation of procedures designed to enhance coronary collateral blood flow. Circ. Res. 10:142–147, 1962.PubMedCrossRefGoogle Scholar
  16. 16.
    Fam, W.M. and M. McGregor, Effect of coronary vasodilator drugs on retrograde flow in areas of chronic myocardial ischemia. Circ. Res. 15:355–365, 1964.PubMedCrossRefGoogle Scholar
  17. 17.
    Carter, E.L. and E.J. Roth. Direct nonsuture coronary artery anastomosis in the dog. Ann. Surg. 148:212–218, 1958.PubMedCrossRefGoogle Scholar
  18. 18.
    Hall, R.J., E.M. Khouri, and D.E. Gregg. Coronary-internal mammary artery anastomosis in dogs. Surgery 50:560–567, 1961.PubMedGoogle Scholar
  19. 19.
    Gregg, D.E., E.M. Khouri and C.R. Rayford. Systemic and coronary energetics in the resting unanesthetized dog. Circ. Res. 16:102–113, 1965.PubMedCrossRefGoogle Scholar
  20. 20.
    Khouri, E.M. and D.E. Gregg. An inflatable cuff for zero determination in blood flow studies. J. Appl. Physiol. 23:395–397, 1967.PubMedGoogle Scholar
  21. 21.
    Elliot, E.C., E.M. Khouri, J.A. Snow and D.E. Gregg. Direct measurement of coronary collateral blood flow in conscious dogs by electromagnetic flowmeter. (Manuscript in preparation).Google Scholar
  22. 22.
    Bassingthwaighte, J.B., T. Strandell and D.E. Donald. Estimation of coronary blood flow by washout of diffusible indicators. Circ. Res. 23:259–278, 1968.PubMedCrossRefGoogle Scholar
  23. 23.
    Pasyk, S., C.M. Bloor, E.M. Khouri and D.E. Gregg. Systemic and coronary effects of coronary artery occlusion in the unanesthetized dog. Am. J. Physiol. 220:646–654, 1971.PubMedGoogle Scholar
  24. 24.
    Menick, F.J., F.C. White and C.M. Bloor. Coronary collateral circulation: Determination of an anatomical anastomotic index of functional collateral flow capacity. Am. Heart J. 82:503–510, 1971.PubMedCrossRefGoogle Scholar
  25. 25.
    Schaper, W., J. Schaper, R. Xhonneux and R. Vendesteene. The morphology of intercoronary anastomoses in chronic coronary artery occlusion. Cardiovasc. Res. 3:315–323, 1969.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1973

Authors and Affiliations

  • Eric C. Elliot
    • 1
  1. 1.Department of Cardiorespiratory Diseases, Walter Reed Army Medical CenterWalter Reed Army Institute of ResearchUSA

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