Challenges to the Adenosine Hypothesis for the Regulation of Coronary Blood Flow

  • Robert M. Berne
  • Rafael Rubio
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 39)


In the past few years there have been several objections raised to the concept that adenosine is involved in reactive hyperemia and in the adjustment of coronary blood flow to myocardial needs. In some cases (1, 2, 3) the reports have essentially repudiated the hypothesis whereas in others (4, 5) the hypothesis has been modified. Furthermore, there is lack of agreement of experimental results bearing on certain aspects of the hypothesis. It is the purpose of this communication to consider the points raised by critics of the adenosine hypothesis and to attempt to clarify them where this seems possible.


Interstitial Fluid Coronary Blood Flow Adenine Nucleotide Reactive Hyperemia Coronary Dilation 
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Copyright information

© Plenum Press, New York 1973

Authors and Affiliations

  • Robert M. Berne
    • 1
  • Rafael Rubio
    • 1
  1. 1.Department of Physiology, School of MedicineUniversity of VirginiaCharlottesvilleUSA

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