Challenges to the Adenosine Hypothesis for the Regulation of Coronary Blood Flow
In the past few years there have been several objections raised to the concept that adenosine is involved in reactive hyperemia and in the adjustment of coronary blood flow to myocardial needs. In some cases (1, 2, 3) the reports have essentially repudiated the hypothesis whereas in others (4, 5) the hypothesis has been modified. Furthermore, there is lack of agreement of experimental results bearing on certain aspects of the hypothesis. It is the purpose of this communication to consider the points raised by critics of the adenosine hypothesis and to attempt to clarify them where this seems possible.
KeywordsInterstitial Fluid Coronary Blood Flow Adenine Nucleotide Reactive Hyperemia Coronary Dilation
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