Abstract
In clinical terms, shock has been defined as hypotension, tachycardia, cold and clammy extremities, oliguria, stupor, and collapse. In physiological terms, it has been defined as low cardiac output with high resistance. These definitions have been based on data obtained in the dog subjected to the Wiggers’ type of experimental hemorrhagic shock and in patients with hemorrhagic and cardiogenic shock (3–5,9,19,20). Moreover, the concept of shock as low output-high resistance appears intuitively attra ctive since, experimentally, pressure and flow diminish as blood volume decreases and flow ceases when pressure falls to zero.
This research was supported by United States Army Contract DADA 17-71-C-9089.
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References
Bassin, R., B.C. Vladick, A.E. Kark, and W.C. Shoemaker. Rapid and slow hemorrhage in man. Ann. Surg. 173: 325, 1971.
Carey, J.S., R.S. Brown, P.A. Mohr, D.O. Monson, S.T. Yao, and W.C. Shoemaker. Cardiovascular function in shock. Circulation 35: 327, 1967.
Cournand, A., R.L. Riley, S.E. Bradley, E.S. Breed, R.P. Noble, H.D. Lauson, M.I. Gregersen, and D.W. Richards. Studies of the circulation in clinical shock. Surgery 13: 964, 1943.
Fries, E.D., H.W. Schnaper, R.L. Johnson, and G.E. Schreiner. Hemodynamic alterations in acute myocardial infarction. J. Clin. Invest. 31: 131, 1952.
Hopkins, R.W., G. Sabga, I. Penn, and F.A. Simeone. Hemodynamic aspects of hemorrhagic and septic shock. JAMA 191: 127, 1965.
Hamilton, W.F., J.W. Moore, J.M. Kinsman, and R.G. Spurling. Studies on the circulation. Am. J. Physiol. 99: 534, 1932.
Kho, L.K., and W.C. Shoemaker. Evaluation of therapy in clinical shock by cardiorespiratory measurements. Surg. Gynecol. Obstet. 127: 81, 1968.
Kim, S.I., J.M. Desai, and W.C. Shoemaker. Sequence of cardiorespiratory alterations after gradual prolonged hemorrhage in conscious dogs. Am. J. Physiol. 216: 1044, 1969.
Richards, D.W., Jr. Circulation in traumatic shock in man. Harvey Lectures 39: 217, 1943–44.
Severinghaus, J.W. Oxyhemoglobin dissociation curve correction for temperature and pH variation in human blood. J. Appl. Physiol. 12: 485, 1958.
Shoemaker, W.C. Shock: Chemistry and Therapy. Springfield, 111.: Charles C Thomas, 1967.
Shoemaker, W.C. Sequential hemodynamic patterns in various causes of shock. Surg. Gynecol. Obstet. 132: 411, 1970.
Shoemaker, W.C. Analysis of physiologic mechanisms in various etiologic types of clinical shock from sequential cardiorespiratory measurements. Excerpta Med., in press.
Shoemaker, W.C., D.M. Boyd, S.I. Kim, R.S. Brown, D.A. Dreiling, and A.E. Kark. Sequential oxygen transport and acid-base changes after trauma to the unanesthetized patient. Surg. Gynecol. Obstet., in press.
Shoemaker, W.C., J.S. Carey, S.T. Yao, P.A. Mohr, J.J. Amato, K.J. Printen, R.D. Corley, and D.O. Monson. Hemodynamic alterations in acute cardiac tamponade after penetrating injuries of the heart. Surgery 67: 754, 1970.
Shoemaker, W.C., L. Lim, D.M. Boyd, R.S. Corley, J.M. Reinhard, D.A. Dreiling, and A.E. Kark. Sequential hemodynamic events after trauma to the unanesthetized patient. Surg. Gynecol. Obstet. 132: 651, 1971.
Shoemaker, W.C., P.A. Mohr, K.J. Printen, R.S. Brown, J.J. Amato, J.S. Carey, S. Youssef, J. Reinhard, S.I. Kim, and A.E. Kark. Treatment of uncomplicated septic shock: Use of sequential physiologic measurements as guides to therapy. Surg. Gynecol. Obstet. 131: 245, 1970.
Shoemaker, W.C., K.J. Printen, J.J. Amato, D.O. Monson, J.S. Carey, and K. O’Connor. Hemodynamic patterns after acute anesthetized and unanesthetized trauma. Arch. Surg. 95: 492, 1967.
Weil, M.H., and H. Shubin. Diagnosis and Treatment of Shock. Baltimore: Williams & Wilkins, 1966.
Wiggers, C.J. Physiology of Shock. New York: Commonwealth Fund, 1950.
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Shoemaker, W.C. (1972). Physiologic Mechanisms in Clinical Shock. In: Hinshaw, L.B., Cox, B.G. (eds) The Fundamental Mechanisms of Shock. Advances in Experimental Medicine and Biology, vol 23. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9014-9_7
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