Abstract
Over the last several years, investigations in our laboratories have centered around the problem of differentiation and development of the plasma cell line. The chicken has been the primary animal model used because this cell line can be easily manipulated by bursectomy in this species (1). Stem cells, originally located in the yolk sac, begin migration into the bursa of Fabricius around the 13th day of incubation and assume lymphoid features in that environment (2). Removal of the bursa on or before the 17th day of incubation can prevent seeding of its lymphoid cells to extra-bursal sites. As a consequence, subsequent germinal center and plasma cell development is prevented and agammaglobulinemia ensues (3). Chemical bursectomy, produced by testosterone administration early in embryonic life, can similarly abort development of the plasma cell line (4). Consistent with this and other evidence indicating that the bursa is the site of induction for the immunoglobulin-producing line of cells (5–7), immunoglobulin synthesis occurs in the bursa several days prior to its appearance in other lymphoid organs (8).
Research currently supported by USPHS grants No. AI08345, AI42973, GM43118, FR00463 and AM13535, and by The American Cancer Society.
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© 1971 Plenum Press, New York
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Cooper, M.D., Kincade, P.W., Bockman, D.E., Lawton, A.R. (1971). A New Theoretical Model of Plasma Cell Differentiation. In: Lindahl-Kiessling, K., Alm, G., Hanna, M.G. (eds) Morphological and Functional Aspects of Immunity. Advances in Experimental Medicine and Biology, vol 12. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9011-8_3
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DOI: https://doi.org/10.1007/978-1-4615-9011-8_3
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