The Fate of Lymph-Borne Immunoblasts

  • Marilyn E. Smith
  • J. G. Hall
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 12)


The efferent lymph from a single lymph node of a sheep consists of small lymphocytes, the occasional eosinophil and a background resting level of 2% of immunoblasts. About three days after antigenic stimulation of the lymph node, by injecting, for instance a bacterial suspension subcutaneously into the drainage area of the node, the output of lymphocytes has doubled and immunoblasts constitute up to 40% of that output (1). Similar basophilic blast cells form up to 15% of the cells in the thoracic duct lymph of rats about three days after antigen has been injected subcutaneously to the drainage area of superficial nodes which contribute their efferent lymph to the thoracic duct (2).


Lamina Propria Thoracic Duct Small Lymphocyte Brucella Abortus Superficial Node 
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  1. 1.
    J. G. Hall and B. Morris, Quart. J. Exp. Physiol., 148:235, 1903.Google Scholar
  2. 2.
    E. J. Delorme, J. Hodgett, J. G. Hall, and P. Alexander, Proc. Roy. Soc., B, 174:229, 1969.CrossRefGoogle Scholar
  3. 3.
    A. J. Cunningham, J. B. Smith, and E. H. Mercer, J. Exp. Med., 124:701, 1966.PubMedCrossRefGoogle Scholar
  4. 4.
    J. G. Hall, Ann. Rev. Scientific Basis of Medicine, in press.Google Scholar
  5. 5.
    J. G. Hall, B. Morris, G. D. Moreno, and M. C. Bessis, J. Exp. Med., 125:91, 1967.PubMedCrossRefGoogle Scholar
  6. 6.
    S. Denham, J. G. Hall, A. Wolf, and P. Alexander, Transplantation, 7:194, 1969.PubMedCrossRefGoogle Scholar
  7. 7.
    M. S. C. Birbeck and J. G. Hall, Nature, 214:183, 1967.PubMedCrossRefGoogle Scholar
  8. 8.
    J. L. Gowans and E. J. Knight, Proc. Roy. Soc., B, 159:257, 1964.CrossRefGoogle Scholar
  9. 9.
    J. G. Hall, Lancet, i: 125, 1969.Google Scholar
  10. 10.
    A. R. Dain and J. G. Hall, Vox. Sang., 13:201, 1967.CrossRefGoogle Scholar
  11. 11.
    J. G. Hall and M. E. Smith, Nature, 226:262, 1970.PubMedCrossRefGoogle Scholar
  12. 12.
    M. E. Smith, to be published.Google Scholar
  13. 13.
    D. R. Tourville, R. H. Adler, J. Bienenstock, and T. B. Tomasi, J. Exp. Med., 129:411, 1969.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1971

Authors and Affiliations

  • Marilyn E. Smith
    • 1
  • J. G. Hall
    • 1
  1. 1.Chester Beatty Research Institute: Institute of Cancer ResearchBelmontEngland

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