Skip to main content

History of Research on Chemical Mutagenesis

  • Chapter


The interest in mutation is as old as the modern science of genetics. It is well known that the term “mutation” was coined by de Vries for sudden hereditary changes in Oenothera; although we now realize that these changes were not mutations sensu stricto, the term has been retained. De Vries was also the first to dream of the induction of “directed mutations” that would provide man with “unlimited power over Nature.” This dream has been a major spur to the search for chemical mutagens. In 1914, T. H. Morgan reported on unsuccessful attempts to produce mutations in Drosophila by treatment with alcohol or ether. Mann, in 1923, likewise failed to obtain mutations from treatment of Drosophila with a variety of chemicals, including morphine, quinine, and a number of metal salts. During the 1920s, mutation research was put on a firm basis by H. J. Muller, who developed the concept of “mutation rate” and devised objective, efficient, and quantitative techniques for its measurement. These techniques proved their value first in the discovery and analysis of the mutagenic action of ionizing radiation, but they were soon applied also to tests of chemicals. Muller himself obtained negative results with several chemicals, but Russian workers (Lobashov, Saccharov, Magrzhikovskaya) claimed success for ammonia, iodine, potassium permanganate, and copper sulfate; for the last-named substance, confirmatory data were published by Law in the United States. Although in these experiments the differences between the frequencies of sex-linked lethals in control and treated flies were statistically significant, treatment effects were always small and rarely reached or exceeded 1% lethals. Since at that time the striking differences between spontaneous mutation frequencies in successive broods were not known, one cannot exclude the possibility that the effective treatments had acted simply by altering the rate of sperm utilization. It would be interesting to repeat some of these experiments with a rigorous brood pattern technique.


  • Mutagenic Action
  • Organic Peroxide
  • Nitrogen Mustard
  • Chemical Mutagenesis
  • Mutation Research

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

This is a preview of subscription content, access via your institution.

Buying options

USD   29.95
Price excludes VAT (USA)
  • DOI: 10.1007/978-1-4615-8972-3_1
  • Chapter length: 19 pages
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
USD   84.99
Price excludes VAT (USA)
  • ISBN: 978-1-4615-8972-3
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book
USD   109.00
Price excludes VAT (USA)


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


Download references

Author information

Authors and Affiliations


Editor information

Editors and Affiliations

Rights and permissions

Reprints and Permissions

Copyright information

© 1973 Plenum Press, New York

About this chapter

Cite this chapter

Auerbach, C. (1973). History of Research on Chemical Mutagenesis. In: Hollaender, A. (eds) Chemical Mutagens. Springer, Boston, MA.

Download citation

  • DOI:

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-8974-7

  • Online ISBN: 978-1-4615-8972-3

  • eBook Packages: Springer Book Archive