Effects on DNA: Transforming Principle

Herriott, Roger M.

doi:10.1007/978-1-4615-8966-2_6

Roger M. Herriott²

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11 Citations

Abstract

Genetic transformation in bacteria involves the transfer of hereditary determinants from ruptured or lysed cells of one strain to a recipient strain which then develops characteristics of the donor cell line. It was this experiment which led to the discovery that DNA is the carrier of heritable properties (Avery et al., 1944). DNA can be purified and stored and will confer the specific properties soon after being incorporated by recipient cells. DNA from transformable bacteria is particularly suited for studies of mutagenesis for it is quite stable and its genetic characteristics can be assayed relatively precisely.

The writer acknowledges support from Public Health Service research grant AI-01218 from the National Institutes of Allergy and Infectious Diseases; and from Atomic Energy Commission contract AT(30-1)-1371.

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Department of Biochemistry, School of Hygiene and Public Health, The Johns Hopkins University, Baltimore, Maryland, USA
Roger M. Herriott

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Division of Biology, Oak Ridge National Laboratory, Oak Ridge, Tennessee, USA
Alexander Hollaender

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Herriott, R.M. (1971). Effects on DNA: Transforming Principle. In: Hollaender, A. (eds) Chemical Mutagens. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-8966-2_6

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