Abstract
The interaction of foreign macromolecular antigen with immunocompetent, antigen-specific precursor lymphocytes initiates two distinct responses, cellular and humoral immunity. Cellular immune responses (delayed hypersensitivity and the various rejection phenomena) are mediated by T cells which recognize antigen by specific membrane receptors whose precise nature is yet to be defined. T cells respond primarily to protein or glycoprotein antigens rather than polysaccharides, and after stimulation, may release biologically active mediators which are responsible for the inflammatory response and tissue damage characteristic of delayed hypersensitivity reactions. Stimulation of T cells with membrane glycoprotein alloantigens on foreign cells leads to proliferative responses the mixed lymphocyte reaction (MLR) and the ability to specifically lyse target cells bearing the sensitizing antigen (the cytotoxic lymphocyte response). Humoral immune responses are mediated by lymphocytes which are functional homologs of bursa of Fabricius cells in birds. These precursors of antibody producing cells (B cells) recognize a wide variety of antigenic determinants by specific membrane Ig receptors and respond by synthesizing and secreting antibody specific for the stimulating antigenic determinant (Katz, 1977; Cantor and Weissman, 1975; Warner, 1974).
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Pierce, C.W., Kapp, J.A. (1978). L-Glutamic Acid60-L-Alanine30-L-Tyrosine10 (GAT): A Probe for Regulatory Mechanisms in Antibody Responses. In: Atassi, M.Z., Stavitsky, A.B. (eds) Immunobiology of Proteins and Peptides · I. Advances in Experimental Medicine and Biology, vol 98. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-8858-0_24
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DOI: https://doi.org/10.1007/978-1-4615-8858-0_24
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