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Alterations in Peroxisomes of Hepatomas

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Morris Hepatomas

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 92))

Summary

Perixosomes are considered to provide a profitable tool in the study of differentiation of hepatocytes at the level of intracellular organelles. Thus, a review was made on the features of hepatocyte peroxisomes and alterations thereof in hepatomas. The following are suggested as characteristic traits of hepatomas.

  1. (1)

    Alterations corresponding to the growth rate and/or the degree of differentiation of the tumors. For example, the number of peroxisomes and activity of catalase are approximately inversely related to this parameter of the tumors. Furthermore, it is possible to distinguish highly differentiated hepatomas from well and poorly differentiated tumors with respect to differences of the abnormal response of peroxisomes to peroxisome-proliferating agents.

  2. (2)

    Alterations relating to retrodifferentiation in the tumors. The multiplicity pattern of catalase of hepatomas resembles closely that of the fetal enzymes, and this fetal pattern appears almost regardless of the growth rate and/or the degree of differentiation of the tumors.

  3. (3)

    Alterations presumably relevant to cancerization. The inducive proliferation of peroxisomes seems to be strongly impaired in hepatomas, regardless of the growth rate and/or the degree of differentiation, contrasting with fetal as well as newborn livers.

  4. (4)

    Alterations probably taking place randomly.

Peroxisomes are regarded as phylogenetically primitive organelles and their enzymes may delete progressively through evolutional development. Thus, further studies on peroxisomes may concern phylogenetical aspects of neoplasia.

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Authors and Affiliations

  1. Department of Pathology Cancer Research Institute, Sapporo Medical College, Sapporo 060, Japan

    Hideyuki Tsukada, Yohichi Mochizuki & Mikio Gotoh

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  1. Hideyuki Tsukada
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  2. Yohichi Mochizuki
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Editors and Affiliations

  1. Department of Biochemistry and Howard Cancer Research Center, Howard University Medical School, Washington, D.C., USA

    Harold P. Morris  & Wayne E. Criss  & 

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Tsukada, H., Mochizuki, Y., Gotoh, M. (1978). Alterations in Peroxisomes of Hepatomas. In: Morris, H.P., Criss, W.E. (eds) Morris Hepatomas. Advances in Experimental Medicine and Biology, vol 92. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-8852-8_14

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  • DOI: https://doi.org/10.1007/978-1-4615-8852-8_14

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