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Mechanism of Action of Luteinizing Hormone Releasing Hormone and Thyrotropin Releasing Hormone in the Anterior Pituitary Gland and Modulation of their Activity by Peripheral Hormones

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Hypothalamic Peptide Hormones and Pituitary Regulation

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 87))

Abstract

A new era of neuroendocrinology started with the elucidation of the structure of porcine and ovine thyrotropin releasing hormone (TRH), the neurohormone controlling the activity of thyrotropin (TSH) and possibly prolactin-secreting cells, as being (pyro)Glu-His-Pro-NH2 (1,2). This achievement was soon followed by the isolation of luteinizing hormone-releasing hormone (LHRH), the neurohormone which stimulates the release of both luteinizing hormone (LH) and follicle stimulating hormone (FSH), and the characterization of LHRH as a decapeptide having the following structure: (pyro)Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2 (3,4). More recently, a tetradecapeptide, H-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH, was isolated from ovine and porcine hypothalami (5,6) on the basis of its ability to inhibit growth hormone (GH) release and is called somatostatin or GH release inhibiting hormone.

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Authors and Affiliations

  1. Medical Research Council Group in Molecular Endocrinology, Le Centre Hospitalier de l’Université Laval, Quebec, G1V 4G2, Canada

    Fernand Labrie, Jacques Drouin, André De Léan, Lisette Lagacé, Louise Ferland & Michèle Beaulieu

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  1. Fernand Labrie
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  2. Jacques Drouin
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  3. André De Léan
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  4. Lisette Lagacé
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  5. Louise Ferland
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  6. Michèle Beaulieu
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  1. University of Texas Health Science Center at Dallas, USA

    John C. Porter

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© 1977 Plenum Press, New York

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Labrie, F., Drouin, J., De Léan, A., Lagacé, L., Ferland, L., Beaulieu, M. (1977). Mechanism of Action of Luteinizing Hormone Releasing Hormone and Thyrotropin Releasing Hormone in the Anterior Pituitary Gland and Modulation of their Activity by Peripheral Hormones. In: Porter, J.C. (eds) Hypothalamic Peptide Hormones and Pituitary Regulation. Advances in Experimental Medicine and Biology, vol 87. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-8849-8_8

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  • DOI: https://doi.org/10.1007/978-1-4615-8849-8_8

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