Abstract
Our experiments with phospholipase C (PLC) have focused on several aspects of terminal skeletal muscle differentiation: how does fusion occur and how is fusion related to other events of terminal differentiation. Elsewhere (Leung et al., 1973; Leung et al., 1975) we have reported that PLC releases a number of proteins from the surfaces of myogenic cells and we have suggested that at least one of these proteins is involved in the fusion process. Since the theme of this meeting is the relationship of cell division to cell differentiation, I shall briefly describe several experiments which suggest that (1) mononucleated myogenic cells withdraw from the cell cycle prior to fusing and (2) there exists, prior to and separable from the fusion event, a recognition step in which mononucleated cells line-up and remain in close association with one another.
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Nameroff, M. (1977). Fusion, Phospholipase C, and Myogenesis. In: Nichols, W.W., Murphy, D.G. (eds) Regulation of Cell Proliferation and Differentiation. Cellular Senescence and Somatic Cell Genetics. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-8846-7_6
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DOI: https://doi.org/10.1007/978-1-4615-8846-7_6
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