Abstract
Structure-activity relationships of insecticides have been a subject of investigations for many years since the development of synthetic insecticides such as DDT and organophosphates. In most cases, these studies were based on the comparison of insect killing potencies of a variety of analogs and derivatives of a parent compound. However, since the action of an insecticide in killing insects is exerted as a result of a chain of reactions, it is difficult to relate such killing potencies to the chemical structures of the insecticide. The process of toxic action of an insecticide is summarized as follows.
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References
Burt, P.E., and Goodchild, R., 1971, The site of action of pyrethrin I in the nervous system of the cockroach Periplaneta americana L., Entomol. Exp. Appl. 14: 179.
Camougis, G., 1973, Mode of action of Pyrethrin on arthropod nerves, in: Pyrethrum, The Natural Insecticide ( J.E. Casida, ed.), pp. 211–222, Academic Press, New York.
Camougis, G., and Davis, W., 1971, A comparative study of the neuropharmacological basis of action of Pyrethrins, Pyrethrum Post 11: 7.
Fahmy, M.A.H., Fukuto, T.R., Metealf, R.L., and Holmstead, R.L., 1973, Structure-activity correlations in DDT analogs, J. Agr. Food Chem. 21: 585.
Fukami, J., Nakatsugawa, T., and Narahashi, T., 1959, The relation between chemical structure and toxicity in rotenone derivatives, Japan. J. Appl. Entomol. Zool. 3: 259.
Fukuto, T.R., 1971, Relationships between the structure of organo-phosphorus compounds and their activity as acetylcholinesterase inhibitors, Bull. World Health Org. 44: 31.
Hille, B., 1968, Pharmacological modifications of the sodium channels of frog nerve, J. Gen. Physiol. 51: 199.
Holan, G., 1969, New halocyclopropane insecticides and the mode of action of DDT, Nature (London) 221: 1025.
Holan, G., 1971a, Rational design of insecticides, Bull. World Health Org. 44: 355.
Holan, G., 1971b, Rational design of degradable insecticides, Nature (London) 232: 644.
Lowenstein, O., 1942, A method of physiological assay of pyre-thrum extract, Nature (London) 150: 760.
Metealf, R.L., 1971, Structure-activity relationships for insecticidal carbamates, Bull. World Health Org. 44: 43.
Metcalf, R.L., and Fukuto, T.R., 1968, The comparative toxicity of DDT and analogs to susceptible and resistant houseflies and mosquitos, Bull. World Health Org. 38: 633.
Narahashi, T., 1962, Effect of the insecticide allethrin on membrane potentials of cockroach giant axons, J. Cell. Comp. Physiol. 59: 61.
Narahashi, T., 1971, Effects of insecticides on excitable tissues, in:Advances in Insect Physiology, Vol. 8 ( J.W.L. Beament, J.E. Treherne, and V.B. Wigglesworth, ed.), pp. 1–93, Academic Press, London and New York.
Narahashi, T., 1976, Effects of insecticides on nervous conduction and synaptic transmission, in: Pesticide Biochemistry and Physiology ( C.F. Wilkinson, ed.), pp. 327–352, Plenum Press, New York.
Narahashi, T., and Haas, H.G., 1967, DDT: Interaction with nerve membrane conductance changes, Science 157: 1438.
Narahashi, T., and Haas, H.G., 1968, Interaction of DDT with the components of lobster nerve membrane conductance, J. Gen. Physiol. 51: 177.
Narahashi, T., and Yamasaki, T., 1960, Mechanism of increase in negative after-potential by dicophanum (DDT) in the giant axons of the cockroach, J. Physiol. (London) 152: 122.
Narahashi, T., Nishimura, K., Parmentier, J.L., Takeno, K., and Elliott, M., 1977, Neurophysiological study of the structure- activity relation of pyrethroids, in: Synthetic Pyrethroids (M. Elliott, ed.), pp. 85–97, Symposium Series No. 42, American Chemical Society, Washington, D. C.
Nishimura, K., and Narahashi, T., 1977, Structure-activity relationships of pyrethroids based on direct action on nerve, Pesticide Biochem. Physiol. In press.
Pichon, Y., 1969, Effets du D.D.T. sur la fibre nerveuse isolée d’insecte. Etude en courant et en voltage imposés, J. Physiol. (Paris) 61 (Suppl. 1): 162.
Takeno, K., Nishimura, K., Parmentier, J., and Narahashi, T., 1977, Insecticide screening with isolated nerve preparations for structure-activity relationships, Pesticide Biochem. Physiol. In press.
Welsh, J.H., and Gordon, H.T., 1947, The mode of action of certain insecticides on the arthropod nerve axon, J. Cell. Comp. Physiol. 30: 147.
Wu, C.H., van den Bercken, J., and Narahashi, T., 1975, The structure-activity relationship of DDT analogs in crayfish giant axons, Pesticide Biochem. Physiol. 5: 142.
Yamasaki, T., and Ishii, T. (former name of T. Narahashi), 1952, Studies on the mechanism of action of insecticides, IV, The effects of insecticides on the nerve conduction of insect, Oyo-Kontyu (J. Nippon Soc. Appl. Entomol.) 7: 157.
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Narahashi, T. (1978). Neurophysiological Study of the Structure-Activity Relations of Insecticides. In: Shankland, D.L., Hollingworth, R.M., Smyth, T. (eds) Pesticide and Venom Neurotoxicity. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-8834-4_10
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DOI: https://doi.org/10.1007/978-1-4615-8834-4_10
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