Abstract
Hedin (1) reported that bovine spleen preparations showed proteolytic activity in both acidic and alkaline conditions. Many years later, the acidic-acting peptide hydrolases of this tissue were the subject of several detailed studies, butt little atention was paid to the neutral — alkaline activities. Investigations such as those of LoSpalluto et al. (2) indicated the presence of neutral proteinases in human spleen, also, and the purpose of the present paper is to describe the results of work by Dr. Phyllis Starkey, with the author, on these enzymes.
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References
Hedin, S.G., J. Physiol. 30, 155–175 (1904).
LoSpalluto, J., Fehr, K. and, Ziff, M. In: Tissue Proteinases (Barrett, A.J. and Dingle J.T. eds. North-Holland Publ. Co, Amsterdam and London 1971, pp 263–289
Charney, J. and, Tomarelli, R.M., J. Biol. Chem. 171, 501–505 (1947).
Jovin, T.M., Ann. N.Y. Acad. Sci. 209, 477–496 (1973).
Schumacher, G.F.B. and Schill, W.-B. Anal. Biochem. 48, 9–26 (1972).
Takahashi, S., Seifter, S. and Young, F.C., Biochim. Biophys. Acta 327, 138–145 (1973).
Rindler-Ludwig, R. and Braunsteiner, H., Biochim. Biophys. Acta 379, 606–617 (1974).
Schmidt, W. and Havemann K., Hoppe-Seyler’s Z. Physiol. Chem. 355, 1077–723 (1974).
Dewald, B., Rindler-Ludwig, R., Bretz, U., Baggiolini, M.J. Exp. Med. 1077–1082 (1974).
Lagunoff, D. and Benditt, E.P. Biochemistry, 3, 1427–1431 (1964).
Pastan, I. and Almqvist, S., J. Biol. Chem. 241, 5090–5094 (1966).
Kawiak, J., Vensel, W.H., Kormender, J. and Barnard, E.A., Biochim. Biophys. Acta 225, 172–187 (1971).
Vensel, W.H., Körnender, J. and Barnard, E.A., Biochim. Biophys. Acta 250, 395–407 (1971).
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© 1977 J. Stefan Institute, Ljubljana, Yugoslavia
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Barrett, A.J. (1977). The Neutral Proteinases of Human Spleen. In: Turk, V., Marks, N., Barrett, A.J., Woessner, J.F. (eds) Intracellular Protein Catabolism II. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-8813-9_40
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DOI: https://doi.org/10.1007/978-1-4615-8813-9_40
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