Skip to main content
SpringerLink
Log in

Proteolytic Degradation of Insulin and Glucagon by Enzymes of Rat Liver

  • Chapter
Intracellular Protein Catabolism II

Abstract

Beside the system of thiol-proteindisulfide oxidoreductases (TPO) described in Reinhardsbrunn which catalyzes the cleavage of disulfide groups of insulin, the liver disposes of a spectrum of proteolytic enzymes capable of degrading insulin and also glucagon at a wide range of hormone concentrations. This communication presents new results on the breakdown of 125l-insulin and -glucagon by the so-called insulin-specific proteinase (cytosol) and the lysosomal cathepsins B1, B3, and L.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Brush, J.S., Diabetes 20, 140–145 (1971).

    CAS  Google Scholar 

  2. Burghen, G.A., Kitabchi, A.E., and Brush, J. S., Endocrinology 91, 633–642 (1972).

    Article  PubMed  CAS  Google Scholar 

  3. Ansorge, S., Bohley, P., Kirschke, H., Langner, J., Wiederanders, B., and Hanson, H., in 9. Karlsburger Symp. (Bibergeil, H., Fiedler, H., and Poser, K., eds.), (1974) in press.

    Google Scholar 

  4. Duckworth, W.C., Heinemann, M., and Kitabchi, A.E., Biochim. Biophys. Acta 377, 421–430 (1975).

    PubMed  CAS  Google Scholar 

  5. Ansorge, S., Bohley, P., Kirschke, H., Langner, J., and Hanson, H., Europ. J. Biochem. 19, 283–288 (1971).

    Article  PubMed  CAS  Google Scholar 

  6. Ansorge, S., Kaiser, B., Senger, U., Bohley, P., Langner, J., and Kirschke, H., Acta Biol. Med. Germ. 28, 761–777 (1972).

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Physiologisch-chemisches Institut der Universität, Hollystrasse 1, Halle, Halle (Saale), DDR-402, GDR

    S. Ansorge, H. Kirschke, J. Langner, B. Wiederanders, P. Bohley & H. Hanson

Authors
  1. S. Ansorge
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. H. Kirschke
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J. Langner
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. B. Wiederanders
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. P. Bohley
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. H. Hanson
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Biochemistry J. Stefan Institute, University of Ljubljana, Ljubljana, Yugoslavia

    Vito Turk

  2. New York State Research Institute for Neurochemistry and Drug Addiction, Ward’s Island, New York, USA

    Neville Marks

  3. Strangeways Research Laboratory, Cambridge, C BI 4RN, England

    Alan J. Barrett

  4. Department of Biochemistry and Medicine, University of Miami School of Medicine, Miami, Florida, USA

    J. Frederick Woessner

Rights and permissions

Reprints and permissions

Copyright information

© 1977 J. Stefan Institute, Ljubljana, Yugoslavia

About this chapter

Cite this chapter

Ansorge, S., Kirschke, H., Langner, J., Wiederanders, B., Bohley, P., Hanson, H. (1977). Proteolytic Degradation of Insulin and Glucagon by Enzymes of Rat Liver. In: Turk, V., Marks, N., Barrett, A.J., Woessner, J.F. (eds) Intracellular Protein Catabolism II. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-8813-9_20

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-8813-9_20

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-8815-3

  • Online ISBN: 978-1-4615-8813-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation