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Immune Complex Disease

  • Charles G. Cochrane

Summary

Various types of injury induced by complexes of antigen and anti-body are reviewed. These include reactions in which antibody reacts with antigens that are fixed in tissues or are soluble but localized at a particular site and reactions that occur following localization of circulating immunologic complexes in a particular tissue from the blood stream. Examples of each are reviewed.

The role of mediation systems in the pathogenesis of immunologic disease is stressed. Two examples of mediation pathways are provided in which a sequence of interacting humoral and cellular reactants is activated by antigen-antibody complex and which is responsible for the injurious consequences.

Keywords

Immune Complex Polymorphonuclear Leukocyte Glomerular Basement Membrane Internal Elastic Lamina Serum Sickness 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Charles G. Cochrane
    • 1
  1. 1.Department of ImmunopathologyScripps ClinicLa JollaUSA

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