Various types of injury induced by complexes of antigen and anti-body are reviewed. These include reactions in which antibody reacts with antigens that are fixed in tissues or are soluble but localized at a particular site and reactions that occur following localization of circulating immunologic complexes in a particular tissue from the blood stream. Examples of each are reviewed.
The role of mediation systems in the pathogenesis of immunologic disease is stressed. Two examples of mediation pathways are provided in which a sequence of interacting humoral and cellular reactants is activated by antigen-antibody complex and which is responsible for the injurious consequences.
KeywordsImmune Complex Polymorphonuclear Leukocyte Glomerular Basement Membrane Internal Elastic Lamina Serum Sickness
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