Advertisement

Immunological Surveillance of Cancer

  • Robert S. Schwartz

Abstract

Tumor immunology can be divided into two broad aspects. One of these deals with the immunology of established neoplasms and has as one of its important goals the development of clinically effective immunotherapy. Almost the entire armamentarium of immunology has been applied to this problem. Signs of progress are evident, but much still needs to be learned.

Keywords

Renal Transplant Recipient Ataxia Telangiectasia Cheek Pouch Tumor Immunology Immunological Defense 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Burnet, F.M., 1970. The concept of immunological surveillance. Progr. Exp. Tumor Res. 13: 1.PubMedGoogle Scholar
  2. 2.
    Klein, G., 1973. Tumor immunology. Transpl. Proc. 5: 31.Google Scholar
  3. 3.
    Schwartz, R.S., 1975. Another look at immunologic surveillance. New Engl. J. Med. 293: 181.Google Scholar
  4. 4.
    Stutman, O., 1975. Immunodepression and malignancy. Adv. Cancer Res. 22: 261.PubMedCrossRefGoogle Scholar
  5. 5.
    Magee, B., 1973. “Karl Popper”, Viking Press.Google Scholar
  6. 6.
    Hirsch, M.S., and Murphy, F.A., 1968. Effects of anti-thymocyte serum on Rauscher virus infection of mice. Nature 218: 478.PubMedCrossRefGoogle Scholar
  7. 7.
    Martinez, C., 1964. Effect of early thymectomy on development of mammary tumors in mice. Nature 203: 1188.PubMedCrossRefGoogle Scholar
  8. 8.
    Wortis, H.H., Nehlsen, S., and Owen, J. J., 1971. Abnormal development of the thymus in “nude” mice. J. Exp. Med. 134: 681, 1971.Google Scholar
  9. 9.
    Rygaard, J., 1973. “Thymus and Self”, John Wiley and Sons, New York.Google Scholar
  10. 10.
    Outzen, H.C., Custer, R.P., Eaton, G.J., et. al., 1975. Spontaneous and induced tumor incidence in germfree “nude” mice. J. Reticuloendothelial Soc. 17: 1.Google Scholar
  11. 11.
    Melief, C.J.M., and Schwartz, R.S., 1975. Immunocompetence and malignancy in “Cancer, a Comprehensive Treatise”, Vol. 1 ( F.F. Becker, Editor). Plenum Press, New York.Google Scholar
  12. 12.
    Hoover, R., and Fraumeni, J.F., Jr., 1973. Risk of cancer in renal transplant recipients. Lancet 2: 55.PubMedCrossRefGoogle Scholar
  13. 13.
    Friedman, J.M., and Fialkow, P.J., 1976. Cell marker studies of human tumorigenesis. Transplant. Rev. 28: 2.Google Scholar
  14. 14.
    Miller, G., 1974. The oncogenicity of Epstein-Barr virus. J. Infect. Dis. 130: 187.PubMedCrossRefGoogle Scholar
  15. 15.
    Fialkow, P.J., Klein, E., Klein, G., et. al., 1973. Immunoglobulin and glucose-6-phosphate dehydrogenase as markers of cellular origin in Burkitt lymphoma. J. Exp. Med. 138: 89.PubMedCrossRefGoogle Scholar
  16. 16.
    Moller, G., and Moller, E., 1976. The concept of immunological surveillance against neoplasia. Transplant. Rev. 28: 1.Google Scholar
  17. 17.
    Hecht, F., McCaw, B.K., and Koler, R.D., 1973. Ataxia telangiectasia-clonal growth of translocation lymphocytes. New. Engl. J. Med. 289: 286.PubMedCrossRefGoogle Scholar
  18. 18.
    Taylor, A.M.R., Metcalfe, J.A., Oxford, J.M., and Harnden, D.G., 1976. Is chromatid-type damage in ataxia telangiectasia after irradiation at G0 a consequence of defective repair? Nature 260: 441.PubMedCrossRefGoogle Scholar
  19. 19.
    Paterson, M.C., Smith, B.P., Lohman, P.H.M., Anderson, A.K., and Fishman, L., 1976. Defective excision repair of γ-ray damaged DNA in human ataxia telangiectasia fibroblasts. Nature 260: 444.PubMedCrossRefGoogle Scholar
  20. 20.
    McCann, J., and Ames, B.N., 1976. Detection of carcinogens as mutagens in the Salmonella/microsome test. Proc. Nat. Acad. Sci. 73: 950.PubMedCrossRefGoogle Scholar
  21. 21.
    Byrnes, J.J., Downey, K.M., Black, V.L., and So, A.G., 1976. Azathioprine as a mutagen and carcinogen. J. Clin. Invest. 57: Abstract 461A.Google Scholar
  22. 22.
    Schwartz, R.S., 1972. Immunoregulcition, oncogenic viruses, and malignant lymphomas. Lancet 1: 1266.PubMedCrossRefGoogle Scholar
  23. 23.
    Furth, J., 1975. Hormones as etiological agents in neoplasia in “Cancer: A Comprehensive Treatise” Vol. 1 ( F.F. Becker, Editor). Plenum Press, New York.Google Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Robert S. Schwartz
    • 1
  1. 1.Hematology Service, Department of MedicineTufts University School of MedicineBostonUSA

Personalised recommendations