Current Concepts in Immunology
Immunology is one of the most rapidly developing fields of medicine, and there are several questions basic to our understanding of it that we must answer before a thorough discussion can begin. 1) What series of cellular events take place in the host between the introduction of antigen and the synthesis of antibody? For example, when an injection of tetanus toxoid is given, what cells take up the toxoid and present the antigen to lymphocytes, and how do these lymphocytes interact to eventually synthesize anti-toxoid antibody? Furthermore, what cells are responsible for maintaining the “memory” so important for the tetanus toxoid boosters, or infection with the organism? 2) What cells and regulatory factors are involved between the time of implantation of an allograft or the development of a tumor, and subsequent rejection of the allograft and hopefully the rejection of the tumor? 3) How do the cells involved in the immune response develop embryologically and where are they found in the human lymphoid apparatus? 4) Do the cells involved in immune response possess any unique characteristics that make their identification, function, and quantitation possible for study or clinical evaluation, or both, in various disease states?
KeywordsLymphoid Organ Cell Mediate Immune Reaction Tetanus Toxoid Cell Surface Antigen Secondary Lymphoid Organ
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