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Random and Nonrandom Processes in the Molecular Evolution of Higher Organisms

  • Richard Holmquist
Part of the Advances in Primatology book series (volume 62)

Abstract

I will discuss the usefulness of approaching an understanding of evolution through a conceptual analysis of the random and nonrandom processes which occur at the molecular level of proteins and nucleic acids, rather than volunteer an exposition of mathematical methodology available elsewhere in the literature. A qualitatively incorrect concept, however mathematically transformed and quantified, remains biologically uninformative. A correct concept, even though imperfectly quantified, is at least useful; the quantitation can be improved as additional data and insight permit. With cautious optimism, Vogel et al. (this volume) state: “the prospects may not be so poor, provided that we do not expect to develop a final and altogether perfect concept. Our model should be refined step by step. After the first few steps, the picture admittedly may still be oversimplified, but at least the most obvious flaws of the old one are corrected.” On the other hand, the known facts are not likely to be accounted for by an arbitrary choice of model. The evolutionary model presented here embodies both selective (i. e., deterministic) and probabilistic evolutionary mechanisms; it reasonably accounts, both qualitatively and quantitatively, for both the observed random and nonrandom and the Darwinian and selectively neutral patterns of protein and nucleic acid variation. The values for evolutionary divergence between species which were calculated from this model when it was first published in 1972 (Holmquist et al., 1972; Jukes and Holmquist, 1972a) were at that time 2–4 times higher than the values then considered correct.

Keywords

Maximum Parsimony Codon Position Amino Acid Site Amino Acid Replacement Ancestral Sequence 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • Richard Holmquist
    • 1
  1. 1.Space Sciences LaboratoryUniversity of CaliforniaBerkeleyUSA

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