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Influence of Low Doses of Gestagens on Some Pituitary-Ovarian Functions

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Current Problems in Fertility

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Abstract

The idea of using low doses of gestagens as oral contraceptives (OC) was first explored by Rudel et al. (19). In recent years several reports have appeared describing the clinical results during this kind of treatment, for a summary see (9). Some authors (3, 18) seem to consider the major contraceptive effect of these drugs to be on the cervical mucus, making it hostile to spermatozoa while other investigators (6, 15, 22) believe that this can not be the only explanation.

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References

  1. Aakvaag, A. : Formation of steroid hormones in the porcine ovary in vitro. J. Endocr. 43:25 (1969).

    Google Scholar 

  2. Diczfalusy, E., Goebelsmann, U., Johannisson, E., Tillinger, K.-G., and Wide, L. : Pituitary and ovarian function in women on continuous low dose progestogens; effect of Chlormadinone acetate and Norethisterone. Acta Endocr. (Kbh.) 62:679 (1969).

    Google Scholar 

  3. Elstein, M.: Urinary hormone excretion patterns in Chlormadinone acetate treated patients and the associated cervical mucus changes. In Chlormadinone acetate, a new departure in oral contraception. Editors: G.A. Christie and M. Moore-Robinson. Excerpta med. (Amst.) 1969, p. 46.

    Google Scholar 

  4. Foss, G.L., Svendsen, E.K., Fotherby, K., and Richards, D.J.: Contraceptive action of continuous low doses of norgestrel. Brit. med. J. 4:489 (1968).

    Article  Google Scholar 

  5. Geller, G. : In Chlormadinone acetate, a new departure in oral contraception. Editors: G.A. Christie and M. Moore-Robinson. Excerpta med. (Amst.) 1969, p. 108.

    Google Scholar 

  6. Gibor, Y., Cohen, M.R., and Scommegna, A.: Effect of continuous administration of small doses of Chlormadinone acetate on the cervical mucus and postcoital test. Fertil. Steril. 20:572, (1969).

    Google Scholar 

  7. Jaffe, R.B., and Midgley, A.B. Jr. : Effects of synthetic steroids on serum gonadotropins. In Progress in Conception Control 1968. Editor: D.L. Moyer, J.B. Lippincott, Philadelphia 1968, p. 13.

    Google Scholar 

  8. Johansson, E.D.B.: Progesterone levels in peripheral plasma during the luteal phase of the normal human menstrual cycle measured by a rapid competitive protein binding technique. Acta endocr. (Kbh.) 61:592 (1969).

    Google Scholar 

  9. Larsson-Cohn, U.: Contraceptive treatment with low doses of gestagens. Acta endocr. (Kbh.) Suppl. 144 (1970).

    Google Scholar 

  10. Larsson-Cohn, U., Johansson, E.D.B., Wide, L., and Gemzell, C.: Effects of continuous administration of 0.5 mg of Norethindrone on the plasma levels of progesterone and on the urinary excretion of luteinizing hormone, pregnanediol and total oestrogens. Acta endocr. (Kbh.) 63:216 (1970).

    Google Scholar 

  11. Larsson-Cohn, U., Johansson, E.D.B., Wide, L., and Gemzell, C.: Effectsof continuous administration of 0.5 mg of Chlormadinone acetate on the plasma levels of progesterone and on the urinary excretion of luteinizing hormone and total oestrogens. Acta endocr. (Kbh.) 63:705 (1970).

    Google Scholar 

  12. Larsson-Cohn, U., Johansson, E.D.B., and Gemzell, C.: Effects of continuous daily administration of 0.3 mg of Norethindrone on the plasma levels of progesterone and on the urinary excretion of pregnanediol and total oestrogens. Acta endocr. (Kbh.) 64:38 (1970).

    Google Scholar 

  13. Larsson-Cohn, U., Johansson, E.D.B., Wide, L., and Gemzell, C.: Effects of daily administration of a retrosteroid on the plasma levels of progesterone and on the urinary excretion of luteinizing hormone and total oestrogens. J. Obst. Gynec. Brit. Cwlth. in press.

    Google Scholar 

  14. Larsson-Cohn, U., Johansson, E.D.B., and Gemzell, C: Unpublished.

    Google Scholar 

  15. Martinez-Manautou, C., Giner-Velazquez, J., Aznar-Ramos, R., Lozano-Balderas, M., and Rudel, W.H.: Continuous administration of 0.5 mg of Chlormadinone acetate as a method of regulating fertility without inhibiting ovulation. In Proceedings of the eight international conference of the International Planned Parenthood Federation Santiago Chile 9–15 april 1967. Editors: R.K.B. Hankinson, R.L. Kleinman, P. Eckstein, and H. Romero. IPPF, London, 1967, p. 241.

    Google Scholar 

  16. Orr, A.H., and Elstein, M. : Luteinizing hormone levels in plasma and urine in women during normal menstrual cycles and in women taking combined contraceptives or Chlormadinone acetate. J. Endocr. 43:6l7 (1969).

    Article  Google Scholar 

  17. ∅stergaard, E., and Starup, J.: Occurrence and function of corpora lutea during different forms of oral contraception. Acta Endocr. (Kbh.) 57:386 (1968).

    Google Scholar 

  18. Roland, M.: Norgestrel-induced cervical barrier to sperm migration. J. Reprod. Fert. Suppl. 5:173 (1968).

    Google Scholar 

  19. Rudel, H.W., Martinez-Manautou, J., and Maqueo-Topete, M. : The role of progestogens in the hormonal control of fertility. Fertil. Steril. 16:158 (1965).

    Google Scholar 

  20. Stevens, V.C., and Vorys, N.: The regulation of pituitary function by sex steroids. Obst. Gyn. Survey 22:781 (1967).

    Article  Google Scholar 

  21. Wright, S.W., Fotherby, K., and Fairweather, F.: Effect of daily small doses of norgestrel on ovarian function. J. Obstet. Gynaec. Brit. Cwlth. 77:65 (1970).

    Article  Google Scholar 

  22. Zanartu, J., Rodriguez-Moore, G., Pupkin, M., Salas, O., and Guerrero, R.: Antifertility effect of continuous low-dosage oral progestogen therapy. Brit. med. J. 2:263 (1968).

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Obstetrics and Gynaecology, University Hospital, Uppsala, Sweden

    Ulf Larsson-Cohn

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  1. Ulf Larsson-Cohn
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Editor information

Editors and Affiliations

  1. Royal Caroline Institute, Sweden

    Axel Ingelman-Sundberg (Professor of Obstetrics and Gynecology, Chairman) & Nils-Olov Lunell (Assistant Professor of Obstetrical and Gynecological Endocrinology) (Professor of Obstetrics and Gynecology, Chairman) &  (Assistant Professor of Obstetrical and Gynecological Endocrinology)

  2. Department of Obstetrics and Gynecology, Sabbatsberg Hospital, Stockholm, Sweden

    Axel Ingelman-Sundberg (Professor of Obstetrics and Gynecology, Chairman) (Professor of Obstetrics and Gynecology, Chairman)

  3. Sabbatsberg Hospital, Stockholm, Sweden

    Nils-Olov Lunell (Assistant Professor of Obstetrical and Gynecological Endocrinology) (Assistant Professor of Obstetrical and Gynecological Endocrinology)

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© 1971 Plenum Press, New York

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Larsson-Cohn, U. (1971). Influence of Low Doses of Gestagens on Some Pituitary-Ovarian Functions. In: Ingelman-Sundberg, A., Lunell, NO. (eds) Current Problems in Fertility. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-8651-7_27

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  • DOI: https://doi.org/10.1007/978-1-4615-8651-7_27

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-8653-1

  • Online ISBN: 978-1-4615-8651-7

  • eBook Packages: Springer Book Archive

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