Abstract
A study of invertebrate pharmacology can lead to observations which are of value both to vertebrate and to comparative studies. A number of invertebrate preparations are used as biological assays for compounds which are of interest to vertebrate physiologists and pharmacologists — for example, the leech (Hirudo) dorsal muscle strip as an assay procedure for acetylcholine (Fuehner 1918; Minz 1932); the quahaug [Mercenaria (Venus)] heart as an assay for 5-hydroxytryptamine [5-HT’ (serotonin)] (Welsh 1953); the crayfish stretch receptor neuron as an assay for gamma-aminobutyric acid (GABA) and for Factor I (Wiersma, Furshpan and Florey 1953; Florey 1954); and the crayfish hind gut for the assay of GABA and Factor I (Florey 1961).
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Walker, R.J. (1968). Certain Aspects of the Pharmacology of Helix and Hirudo Neurons. In: Salánki, J. (eds) Neurobiology of Invertebrates. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-8618-0_15
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