Abstract
Since the first description of an eukaryotic ADP-ribosylation system it has been shown that DNA is required for the synthesis of the polymer (1, 2). During the past several years, the enzyme has been purified to homogeneity from various sources (3, 4). It has been demonstrated that the purified enzyme absolutely requires double stranded DNA to express its activity in vitro (5–8), nevertheless covalently closed circular double-stranded DNA does not have any effect on the enzyme activity (9, 10). It has been shown that poly(ADP-ribose) polymerase is activated by and binds to, single or double stranded breaks on DNA (10).
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References
Chambon, P., Weill, J.D., Mandel, P. (1963) Biochem Biophys Res Commun 11: 39–43
Chambon, P., Weill, J.D., Doly, J., Strosser, M.T., Mandel, P. (1966) Biochem Biophys Res Commun 25: 638–643
Mandel, P., Okazaki, H., Niedergang, C. (1982) Prog Nucleic Acid Res Mol Biol 27: 1–51
Ueda, K., Hayaishi, O. (1985) Ann Rev Biochem 54: 73–100
Okayama, H., Edson, C.M., Fukushima, M., Ueda, K., Hayaishi, O. (1977) J Biol Chem 252: 7000–7005
Yoshihara, K., Hahida, T., Tanaka, Y., Ohgushi, H., Yoshihara, H., Kamiya, T. (1978) J Biol Chem 253: 6459–6466
Niedergang, C., Okazaki, H., Mandel, P. (1979) Eur J Biochem 102: 43–57
Shizuta, Y., Ito, S., Nakata, K., Hayaishi, O. (1980) Methods Enzymol 66: 159–165
Benjamin, R.C., Gill, D.M. (1980) J Biol Chem 255: 10502–10508
Ohgushi, H., Yoshihara, K., Kamiya, T. (1980) J Biol Chem 255: 6205–6211
Mandel, P., Okazaki, H., Niedergang, C. (1977) FEBS Lett 84: 331–336
Okazaki, H., Niedergang, C., Mandel, P. (1977) C R Acad Sc Paris 285 Série D 1545–1548
de Murcia, G., Jongstra-Bilen, J., Ittel, M.E., Mandel, P., Delain, E. (1983) Embo J 2: 543–548
Ittel, M.E., Jongstra-Bilen, J., Niedergang, C., Mandel, P., Delain, E. (1985) ADP- Ribosylation of Proteins F.R. Althaus, H. Hilz, S. Shall (eds.). Springer, Berlin, Heidelberg, pp. 60–68.
Maniatis, T., Fritsch, E.F., Sambrook, J. (1982) Molecular Cloning, a Laboratory Manual, Cold Spring Harbor Laboratory, New York
Messing, J. (1983) Methods Enzymol 101 (part C): 20–78
Tseng, A., Lee, W.M.F., Kirsten, E., Hakam, A., McLick, J., Buki, K., Kun, E. (1987) Proc Natl Acad Sci USA 84: 1107–1111
Jongstra-Bilen, J., Ittel, M.E., Niedergang, C., Vosberg, H.P., Mandel, P. (1983) Eur J Biochem 136: 391–396
Petzold, S.J., Booth, B.A., Leimbach, G.A., Berger, N.A. (1981) Biochemistry 20: 7075–7081
Berger, N.A., Petzold, S.J. (1985) Biochemistry 24: 4352–4355
Gaal, J.C., Pearson, C.K. (1986) TIBS 11: 171–175
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© 1989 Springer-Verlag New York Inc.
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Ittel, ME., Jeltsch, JM., Niedergang, C.P. (1989). Sequence Analysis of the DNA Associated with Poly(ADP-Ribose) Polymerase Molecules. In: Jacobson, M.K., Jacobson, E.L. (eds) ADP-Ribose Transfer Reactions. Springer, New York, NY. https://doi.org/10.1007/978-1-4615-8507-7_93
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DOI: https://doi.org/10.1007/978-1-4615-8507-7_93
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