Skip to main content
SpringerLink
Log in

Poly(ADP-Ribose) Glycohydrolase and ADP-Ribosyl Group Turnover

  • Chapter
ADP-Ribose Transfer Reactions

Abstract

Poly(ADP-ribosyl)ation constitutes a novel type of posttranslational covalent modification of nuclear proteins. The synthesis of poly(ADP-ribose) is catalyzed by poly(ADP-ribose) synthetase (1). Recently, poly(ADP-ribose) groups on proteins were found to turn over rapidly in vivo (2, 3). The degradation of poly(ADP-ribose) is carried out by two different types of enzymes. ADP-ribosyl protein lyase cleaves the bond between mono(ADP-ribose) and protein (4). Another enzyme is poly(ADP-ribose) glycohydrolase, which is known to split the ribose-ribose glycosidic bond (5, 6). The glycohydrolase is the major enzyme responsible for polymer degradation in vivo (7). Therefore, the knowledge of its precise mode of action on poly(ADP-ribose) is important for elucidating not only the metabolism of poly(ADP-ribose) but also the biological functions of poly(ADP-ribosyl)ation. In the present study, we purified this glycohydrolase, and investigated its mode of action precisely.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Ueda, K., Hayaishi, O. (1985) Ann Rev Biochem 46: 73–100

    Article  Google Scholar 

  2. Juarez-Salinas, H., Sims, J.L., Jacobson, M.K. (1979) Nature 282: 740–741

    Article  PubMed  CAS  Google Scholar 

  3. Wielckens, K., George, E., Pless, T., Hilz, H. (1983) J Biol Chem 258: 4098–4104

    PubMed  CAS  Google Scholar 

  4. Oka, J., Ueda, K., Hayaishi, O., Komura, H., Nakanishi, K. (1984) J Biol Chem 259: 986–995

    PubMed  CAS  Google Scholar 

  5. Ueda, K. Oka, J., Narumiya, S., Miyakawa, N., Hayaishi, O. (1972) Biochem Biophys Res Commun 46: 516–523

    Article  PubMed  CAS  Google Scholar 

  6. Miwa, M., Tanaka, M., Matsushima, T., Sugimura, T. (1974) J Biol Chem 249: 3475–3482

    PubMed  CAS  Google Scholar 

  7. Miwa, M., Nakatsugawa, K., Hara, K., Matsushima, T., Sugimura, T. (1975) Arch Biochem Biophys 167: 54–60

    Article  PubMed  CAS  Google Scholar 

  8. Hatakeyama, K., Nemoto, Y., Ueda, K., Hayaishi, O. (1986) J Biol Chem 261: 14902–14911

    PubMed  CAS  Google Scholar 

  9. Ito, S., Shizuta, Y., Hayaishi, O. (1979) J Biol Chem 254: 3647–3651

    PubMed  CAS  Google Scholar 

  10. Benjamin, R.C., Gill, D.M. (1980) J Biol Chem 255: 10493–10501

    PubMed  CAS  Google Scholar 

  11. Wielchens, K., Schimidt, A., George, E., Bredehorst, R., Hilz, H. (1982) J Biol Chem 257: 12872–12877

    Google Scholar 

  12. Adametiz, P., Rudolph, A. (1984) J Biol Chem 259: 6841–6846

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Medical Chemistry, Osaka Medical College, Takatsuki, Osaka 569, Japan

    Kazuyuki Hatakeyama, Yasuo Nemoto, Kunihiro Ueda & Osamu Hayaishi

  2. Department of Clinical Science and Laboratory Medicine, Kyoto University Faculty of Medicine, Kyoto 606, Japan

    Yasuo Nemoto & Kunihiro Ueda

  3. Osaka Medical College, Takatsuki, Osaka 569, Japan

    Osamu Hayaishi

Authors
  1. Kazuyuki Hatakeyama
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yasuo Nemoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Kunihiro Ueda
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Osamu Hayaishi
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Biochemistry, Texas College of Osteopathic Medicine, Fort Worth, Texas, 76107-2690, USA

    Myron K. Jacobson

  2. Department of Medicine, Texas College of Osteopathic Medicine, Fort Worth, Texas, 76107-2690, USA

    Elaine L. Jacobson

Rights and permissions

Reprints and permissions

Copyright information

© 1989 Springer-Verlag New York Inc.

About this chapter

Cite this chapter

Hatakeyama, K., Nemoto, Y., Ueda, K., Hayaishi, O. (1989). Poly(ADP-Ribose) Glycohydrolase and ADP-Ribosyl Group Turnover. In: Jacobson, M.K., Jacobson, E.L. (eds) ADP-Ribose Transfer Reactions. Springer, New York, NY. https://doi.org/10.1007/978-1-4615-8507-7_8

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-8507-7_8

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4615-8509-1

  • Online ISBN: 978-1-4615-8507-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation