Abstract
The covalent modification of proteins has been demonstrated to be an important and general in vivo mechanism for metabolic regulation (1). More recently it has been shown that nicotinamide adenine dinucleotide (NAD) can participate in such reactions as a donor of the adenosine diphosphate ribose (ADP-ribose) moiety (2, 3). Although the biological function of these reactions is still unknown, evidence has begun to accumulate suggesting that this class of modification constitutes an important regulatory mechanism.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Chock, P.B., Rhee, S.G., Stadtman, E.R. (1980) Ann Rev Biochem 49: 813–843
Ueda K., Hayaishi O. (1985) Ann Rev Biochem 54: 73–100
Hayaishi O., Ueda K. (1977) Ann Rev Biochem 46: 95–116
Kam B.L., Oppenheimer N.J. (1981) J Org Chem 46: 3268–3272
Cermak, R.C., Vince R. (1981) Tetrahedron Lett 22: 2331–2332
Lettre, H., Haede W., Ruhbaum E. (1952) Annalen der Chemie 579: 123–132
Yoshikawa, M., Kato T., Takenishi T. (1967) Tetrahedron Lett 50: 5065–5068
Furusawa, K., Sekine M., Hata T. (1976) J Chem Soc Perkin I: 1711–1716
Weber, G. (1957) Nature (London) 180: 1409
Shifrin, S., Kaplan, N.O. (1959) Nature (London) 183: 1259
Yost, D.A., Anderson, B.M. (1981) J Biol Chem 256: 3647–3653
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 Springer-Verlag New York Inc.
About this chapter
Cite this chapter
Slama, J.T., Simmons, A.M. (1989). Carba-Nicotinamide Adenine Dinucleotide: Synthesis and Enzymological Application of a Novel Inhibitor of ADP-ribosyl Transfer. In: Jacobson, M.K., Jacobson, E.L. (eds) ADP-Ribose Transfer Reactions. Springer, New York, NY. https://doi.org/10.1007/978-1-4615-8507-7_22
Download citation
DOI: https://doi.org/10.1007/978-1-4615-8507-7_22
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4615-8509-1
Online ISBN: 978-1-4615-8507-7
eBook Packages: Springer Book Archive