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Insect chemosterilants: Their chemistry and application

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Residue Reviews / Rückstands-Berichte

Part of the book series: Residue Reviews / Rückstands-Berichte ((RECT,volume 6))

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Abstract

Sexual sterilization of insects by ionizing radiation and the practical application of this process to insect control have been adequately reviewed in the literature by Baumhover et al. (1955), Bushland and Hopkins (1951 and 1953), Knipling (1955, 1959, 1960 a, and 1960 b), and Lindquist (1955). It is sufficient here to mention briefly the principles and shortcomings of the radiation-sterilization method which provided the impetus to the search for chemosterilants and thus paved a way for this new and promising insect-control tool.

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References

  • Alexander, P.: Radiation-imitating chemicals. Scient. Amer. 202 (No. 1), 99 (1960).

    Article  CAS  Google Scholar 

  • Allen, E., and W. Seaman: Method of assay for ethylenimine derivatives. Anal. Chem. 27, 540 (1955).

    Article  CAS  Google Scholar 

  • Ascher, K. R. S.: Prevention of oviposition in the house fly through tarsal contact agents. Science 125, 938 (1957).

    Article  PubMed  CAS  Google Scholar 

  • Ascher, K. R. S., and I. Hirsch: Inhibition of oviposition in the house fly by ingestion of acaricides (ovicides). Riv. Malariol. 40, 139 (1961).

    CAS  Google Scholar 

  • Bardos, T. J.: Consideration of chemical reaction mechanisms in relationship to the biological action of “dual antagonists”. Biochem. Pharmacol. 11, 256 (1962).

    Article  PubMed  CAS  Google Scholar 

  • Baumhover, A. H., A. J. Graham, B. A. Bitter, D. E. Hopkins, W. D. New, F. H. Dudley, and R. C. Bushland: Screw-worm control through release of sterilized flies. J. Econ. Entomol. 48, 462 (1955).

    Google Scholar 

  • Berenbaum, M. C., and M. Calley: Effect of anti-tumor agents on nondividing cells. Nature 196, 656 (1962).

    Article  PubMed  CAS  Google Scholar 

  • Biesele, J. J.: Mitotic poisons and the cancer problem. New York: Elsevier 1958.

    Google Scholar 

  • Biesele, J. J.: Experimental and therapeutic modification of mitosis. Cancer Research 22, 779 (1962).

    PubMed  CAS  Google Scholar 

  • Block, M., And H. Jackson: The action of triethylenemelamine on the fertility of male rats. Brit. J. Pharmacol. 12, 1 (1957).

    Google Scholar 

  • Boone, I. U., B. S. Rogers, and D. L. Williams: Toxicity, metabolism, and tissue distribution of carbon-14-labeled N,N′,N″-triethylenethiophosphoramide (Thio-TEPA) in rats. Toxicol, appl. Pharmacol. 4, 344 (1962).

    Article  CAS  Google Scholar 

  • Borkovec, A. B.: Sexual sterilization of insects by chemicals. Science 137, 1034 (1962).

    Article  CAS  Google Scholar 

  • Borkovec, A. B., and C. W. Woods: Aziridine chemosterilants. Sulfur-containing aziridines. Adv. Chem. Series 41, 47 (1963).

    Google Scholar 

  • Bottini, A. T., and V. Dev: Structure-activity relationship of ethylenimines. II. Methyl-substituted derivatives of tetramin. J. Med. Pharm. Chem. 5 (No. 5), 925 (1962).

    Article  CAS  Google Scholar 

  • Bushland, R. C., and D. E. Hopkins: Experiments with screw-worm flies sterilized by X-rays. J. Econ. Entomol. 44, 725 (1951).

    Google Scholar 

  • Bushland, R. C., and D. E. Hopkins: Sterilization of screw-worm flies by X-rays and gamma rays. J. Econ. Entomol. 46, 648 (1953).

    Google Scholar 

  • Carlson, E. A., and I. I. Oster: Chemical-mutagen induced mosaicism at the dumpy locus. Genetics 46, 856 (1961).

    Google Scholar 

  • Cattenach, B. M., and R. G. Edwards: The effects of triethylenemelamine on the fertility of male mice. Proc. Roy. Soc. Edinburgh 67 B, 54 (1958).

    Google Scholar 

  • Chamberlain, W. F.: Chemical sterilization of the screw-worm. J. Econ. Entomol. 55, 240 (1962).

    CAS  Google Scholar 

  • Chamberlain, W. F., and D. E. Hopkins: Effect of colchicin on screw-worms. J. Econ. Entomol. 53, 1133 (1960).

    CAS  Google Scholar 

  • Clark, A. M.: Mutagenic activity of the alkaloid heliotrine in Drosophila. Nature 163 (No. 4663), 731 (1959).

    Article  Google Scholar 

  • Clark, A. M.: Sterilization of Drosophila by some pyrrolizidine alkaloids. 2. Vererbungsl. 91, 74 (1960).

    Article  CAS  Google Scholar 

  • Craig, A. W., and H. Jackson: The metabolism of 32-P-labeled triethylene-phosphoramide in relation to its anti-tumour activity. Brit. J. Parmacol. 10, 321 (1955).

    CAS  Google Scholar 

  • Cressman, A. W.: Response of citrus red mite to chemical sterilants. J. Econ. Entomol. 56, 111 (1963).

    CAS  Google Scholar 

  • Davis, D. E.: Gross effects of triethylenemelamine on gonads of starlings. Anat. Record 142 (No. 3), 353 (1962).

    Article  CAS  Google Scholar 

  • Epstein, J., R. W. Rosenthal, and R. J. Ess: Use of 7-(4-nitrobenzyl) pyridine as analytical reagent for ethylenimines and alkylating agents. Anal. Chem. 27, 1435 (1955).

    Article  CAS  Google Scholar 

  • Fahmy, O. G., and M. J. Fahmy: Cytogenetic analysis of the action of carcinogens and tumour inhibitors in Drosophila melanogaster. II. The mechanism of induction of dominant lethals by 2,4,6-tri(ethylenimine)-l,3,5-triazine. Genetics 52, 603 (1954).

    Article  CAS  Google Scholar 

  • Fahmy, O. G., and M. J. Fahmy: Cytogenetic analysis of the action of carcinogens and tumour inhibitors in Drosophila melanogaster. VI. The mutagenic cell-stage response of the male germ line to the nitrogen mustard derivatives of amino acids, carboxylic acids, and amines. Genetic Research 1, 173 (1960).

    Article  Google Scholar 

  • Fahmy, O. G., and M. J. Fahmy: Cytogenetic analysis of the action of carcinogens and tumour inhibitors in Drosophila melanogaster. XI. Mutagenic efficiency of the methyloxy esters on the sperm in relation to molecular structure. Genetics 46, 1111 (1961).

    PubMed  CAS  Google Scholar 

  • Feldmesser, J., M. Beroza, and R. V. Rebois: Effect of chemosterilants on saprophytic nematodes. J. Parasit. 48 (No. 2), 44 (1962).

    Google Scholar 

  • Fox, B. W., H. Jackson, A. W. Craig, and T. D. Glover: Effects of alkylating agents on spermatogenesis in the rabbit. J. Reprod. Fertil. 5, 13 (1963).

    Article  PubMed  CAS  Google Scholar 

  • Goldacre, R. J., A. Loveless, and W. C. J. Ross: Mode of production of chromosome abnormalities by the nitrogen mustards: The possible role of cross-linking. Nature 163, 667 (1949).

    Article  PubMed  CAS  Google Scholar 

  • Goldsmith, E. D.: Anti-metabolites as larvicidal and sterility agents in the insect. Proc. 64th Ann. Meeting Amer. Assoc. Econ. Entomol. Dec. 1952.

    Google Scholar 

  • Goldsmith, E. D., and I. Frank: Sterility in the female fruit fly, Drosophila melanogaster, produced by the feeding of a folic acid antagonist. Amer. J. Physiol. 171 (No. 3), 726 (1952).

    Google Scholar 

  • Goldsmith, E. D., M. H. Harnly, and E. B. Tobias: Folic acid analogs in lower animals. I. The insecta: Drosophila melanogaster. Ann. N. Y. Acad. Sci. 52, 1342 (1950).

    Article  PubMed  CAS  Google Scholar 

  • Goldsmith, E. D., E. B. Tobias, and M. H. Harnly: Folic acid antagonists and the development of Drosophila melanogaster. Anat. Rec. 101, 93 (1948).

    CAS  Google Scholar 

  • Golumbic, C., J. S. Fruton, and M. Bergmann: Chemical reactions of the nitrogen mustard gases. I. The transformations of methyl-bis(ß-chloroethyl)amine in water. J. Org. Chem. 11, 518 (1946).

    Article  CAS  Google Scholar 

  • Hall, S. A.: Trends in insect control agents. J. Washington Acad. Sci. 52 (No. 2), 29 (1962).

    Google Scholar 

  • Harries, F. H.: Effect of certain antibiotics and other compounds on the two-spotted spider mite. J. Econ. Entomol. 54, 122 (1961).

    CAS  Google Scholar 

  • Harris, R. L.: Chemical induction of sterility in the stable fly. J. Econ. Entomol. 55, 882 (1962).

    CAS  Google Scholar 

  • Ihndris, R. W.: Synonyms of cancer chemotherapy agents. Cancer Chemother. Rep. 15, 67 (1961).

    Google Scholar 

  • Ihndris, R. W.: Synonyms of cancer chemotherapy agents. Appendix I. NSC numbers. Cancer Chemother. Rep. 18, 129 (1962).

    Google Scholar 

  • Jackson, H.: Antifertility substances. Pharmacol. Rev. 11, 135 (1959).

    PubMed  CAS  Google Scholar 

  • Jackson, H., B. W. Fox, and A. W. Craig: The effect of alkylating agents on male rat fertility. Brit. J. Pharmacol. 14, 149 (1959).

    PubMed  CAS  Google Scholar 

  • Jackson, H., B. W. Fox, and A. W. Craig: Antifertility substances and their assessment in the male rodent. J. Reprod. Fertil. 2, 447 (1961).

    Article  PubMed  CAS  Google Scholar 

  • Jacobson, M., and W. A. Jones: Insect sex attractants. II. The synthesis of a highly potent gypsy moth sex attractant and some related compounds. J. Org. Chem. 27, 2523 (1962).

    Article  CAS  Google Scholar 

  • Joechle, W.: Biology and biochemistry of reproduction and contraception. Angew. Chem., Internat. ed. 1, 537 (1962).

    Google Scholar 

  • Kilgore, W. W., and R. R. Painter: The effect of 5-fluorouracil on the viability of house fly eggs. J. Econ. Entomol. 55, 710 (1962).

    CAS  Google Scholar 

  • Knipling, E. F.: Possibilities of insect control or eradication through the use of sexually sterile males. J. Econ. Entomol. 48, 459 (1955).

    Google Scholar 

  • Knipling, E. F.: Sterile male method of population control. Science 130, 902 (1959).

    Article  PubMed  CAS  Google Scholar 

  • Knipling, E. F.: Use of insects for their own destruction. J. Econ. Entomol. 53, 415 (1960 a).

    Google Scholar 

  • Knipling, E. F.: The eradication of the screw-worm fly. Scient. Amer. 203 (No. 4), 54 (1960 b).

    Article  CAS  Google Scholar 

  • Knipling, E. F.: Potentialities and progress in the development of chemosterilants for insect control. J. Econ. Entomol. 55, 782 (1962).

    CAS  Google Scholar 

  • Labreque, G. C.: Studies with three alkylating agents as house fly sterilants. J. Econ. Entomol. 54, 684 (1961).

    Google Scholar 

  • Labreque, G. C., P. H. Adcock, and C. N. Smith: Tests with compounds affecting house fly metabolism. J. Econ. Entomol. 53, 803 (1960).

    Google Scholar 

  • Labreque, G. C., D. W. Meifert, and R. L. Fye: A field study on the control of house flies with diemosterilant techniques. J. Econ. Entomol. 56, 150 (1963 a).

    Google Scholar 

  • Labreque, G. C., D. W. Meifert, and H. K. Gouck: Effectiveness of three 2-methylaziridine derivatives as house fly diemosterilants. Florida Entomol. 46, 7 (1963 b).

    Article  Google Scholar 

  • Labreque, G. C., and C. N. Smith: Mating competitiveness of chemosterilized and normal house flies. Science 136, 388 (1962 a).

    Article  Google Scholar 

  • Labreque, G. C., C. N. Smith, and D. W. Meifert: A field experiment in the control of house flies with chemosterilant baits. J. Econ. Entomol. 55, 449 (1962 b).

    Google Scholar 

  • Lindquist, A. W.: The use of gamma radiation for control or eradication of the screw-worm. J. Econ. Entomol. 48, 467 (1955).

    Google Scholar 

  • Lindquist, A. W.: Chemicals to sterilize insects. J. Washington Acad. Sci. 109 Nov. 1961.

    Google Scholar 

  • Loebbecke, E. A., and R. C. Von Borstel: Mutational response of Habrobracon oocytes in metaphase and prophase to ethyl methanesulfonate and nitrogen mustard. Genetics 47, 853 (1962).

    CAS  Google Scholar 

  • Mitlin, N.: Inhibition of development in the house fly by 3,4-methylenedioxyphenyl compounds. J. Econ. Entomol. 49, 683 (1956).

    CAS  Google Scholar 

  • Mitlin, N., and A. M. Baroody: Use of the house fly as a screening agent for tumor-inhibiting agents. Cancer Res. 18, 708 (1958 a).

    PubMed  CAS  Google Scholar 

  • Mitlin, N., and A. M. Baroody: The effect of some biologically active compounds on growth of house fly ovaries. J. Econ. Entomol. 51, 384 (1958 b).

    CAS  Google Scholar 

  • Mitlin, N., B. A. Butt, and T. J. Shortino: Effect of mitotic poisons on house fly oviposition. Physiol. Zool. 30, 133 (1957).

    CAS  Google Scholar 

  • Montgomery, J. A.: The relation of anticancer activity to chemical structure. Cancer Res. 19, 447 (1959).

    PubMed  CAS  Google Scholar 

  • Morgan, P. B., and G. C. Labreque: The effect of apholate on the ovarian development of house flies. J. Econ. Entomol. 55, 626 (1962).

    CAS  Google Scholar 

  • Mukherjee, M. C.: Sterility in Drosophila melanogaster consequent on using a mammalian oral contraceptive. Science and Culture 27, 497 (1961).

    Google Scholar 

  • Nadkarni, M. V., E. G. Trams, and P. K. Smith: Preliminary studies on the distributions and fate of TEM, TEPA, and myleran in the human. Cancer Res. 19, 713 (1959).

    PubMed  CAS  Google Scholar 

  • Ogsten, A. G., E. R. Holiday, J. St. L. Philpot, and L. A. Stocken: Trans. Faraday Soc. 44, 45 (1948).

    Article  Google Scholar 

  • Piquett, P. G., and J. C. Keller: A screening method for diemosterilants of the house fly. J. Econ. Entomol. 55, 261 (1962).

    Google Scholar 

  • Plapp, F. W., Jr., W. S. Bigley, G. A. Chapman, and G. W. Eddy: Metabolism of metaphoxide in mosquitoes, house flies, and mice. J. Econ. Entomol. 55, 607 (1962).

    CAS  Google Scholar 

  • Purdom, C. E.: Mutagenic effects of nitrogen mustard derivatives of azobenzene compounds in Drosophila melanogaster. Biochem. Pharmacol. 5, 206 (1960).

    Article  PubMed  CAS  Google Scholar 

  • Rapoport, I. A.: Derivatives of carbamic acid and mutations. Byull. Eksp. Biol. Med. 23, 198 (1947).

    CAS  Google Scholar 

  • Roehrborn, G.: Mutagenitatsuntersuchungen mit l,4-Dimethylsulfonoxy-l,4-dimethylbutan an Drosophila melanogaster. 2. Vererbungsl. 90, 457 (1959).

    Article  CAS  Google Scholar 

  • Roehrborn, G.: Chemische Konstitution und mutagene Wirkung. Klassifizierungsversuch chemischer Mutagene. Experientia 16, 523 (1960).

    Article  PubMed  CAS  Google Scholar 

  • Roehrborn, G.: Chemische Konstitution und mutagene Wirkung. II. Triazinderivate. 2. Vererbungsl. 93, 1 (1962).

    CAS  Google Scholar 

  • Ross, W. C. J.: The reactions of certain epoxides in aqueous solutions. J. Chem. Soc. 1950, 2257.

    Google Scholar 

  • Ross, W. C. J.: Biological alkylating agents. London: Butterworths 1962.

    Google Scholar 

  • Shaw, J. G., and M. S. Riviello: Sterility in the Mexican fruit fly caused by chemicals. Science 137, 754 (1962 a).

    Article  PubMed  CAS  Google Scholar 

  • Shaw, J. G., and M. S. Riviello: Investigaciones sobre empleo de productos quimicos como esterilizantes sexuales para la mosca de la fruta. Ciencia 22 (No. 1–2), 17 (1962 b).

    CAS  Google Scholar 

  • Stacey, K. A., M. Cobb, S. F. Cousens, and P. Alexander: Ann. N. Y. Acad. Sci. 68, 682 (1958).

    Article  PubMed  CAS  Google Scholar 

  • Steinberger, E.: A quantitative study of the effect of an alkylating agent (triethylenemelamine) on the seminiferous epithelium of rats. J. Reprod. Fertil. 3, 250 (1962).

    Article  PubMed  CAS  Google Scholar 

  • Steinberger, E., W. O. Nelson, A. Boccabella, and W. J. Dixon: The radiomimetic effect of triethylenemelamine on reproduction in the male rat. Endocrinol. 65, 40 (1959).

    Article  CAS  Google Scholar 

  • Tenhet, J. N.: Effect of pyrethrum on oviposition of the cigarette beetle. J. Econ. Entomol. 40, 910 (1947).

    PubMed  CAS  Google Scholar 

  • Vandenbergh, J. G., and D. E. Davis: Gametocidal effects of triethylenemelamine on a breeding population of redwinged blackbirds. J. Wildlife Management 26, 366 (1962).

    Article  Google Scholar 

  • Weidhaas, D. E.: Chemical sterilization of mosquitoes. Nature 195, 786 (1962).

    Article  PubMed  CAS  Google Scholar 

  • Weidhaas, D. E., H. R. Ford, J. B. Gahan, and C. N. Smith: Preliminary observations on the chemosterilization of mosquitoes. Proc. N. J. Mosq. Extermin. Assoc. 48, 106 (1961).

    CAS  Google Scholar 

  • Whitelock, O. V. St.: Comparative clinical and biological effects of alkylating agents. Ann. N. Y. Acad. Sci. 68, 657 (1958).

    Google Scholar 

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Authors and Affiliations

  1. Entomology Research Division, Agricultural Research Service, U. S. Department of Agriculture, Beltsville, Maryland, USA

    Alexej B. Bořkovec

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  1. Alexej B. Bořkovec
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  1. Department of Entomology, University of California, Riverside, California, USA

    Francis A. Gunther

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© 1964 Springer-Verlag OHG · Berlin · Göttingen · Heidelberg

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Bořkovec, A.B. (1964). Insect chemosterilants: Their chemistry and application. In: Gunther, F.A. (eds) Residue Reviews / Rückstands-Berichte. Residue Reviews / Rückstands-Berichte, vol 6. Springer, New York, NY. https://doi.org/10.1007/978-1-4615-8386-8_7

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  • DOI: https://doi.org/10.1007/978-1-4615-8386-8_7

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