Abstract
Tryptophan is an indispensable amino acid in animal nutrition. Without it young animals cease to grow, and adult animals can no longer maintain nitrogen equilibrium. Hence, dietary intake is ultimately the starting point for any consideration of the regulation of the content of this amino acid in the CNS. Dietary deficiency of tryptophan results quickly in a decrease in the content of this amino acid in brain (Gessa et al., 1974; Dickerson and Pao, 1975). This depletion also accounts for the known decrease in tissue 5-hydroxytryptamine (5-HT, serotonin), including that of the brain (Eber and Lembeck, 1958; Gal and Drewes, 1962; Culley et al., 1963). Some species (e.g., pig and rat) can use D-tryptophan for part of their nutritional requirement (Baker et al., 1971) presumably converting it by way of oxidative deamination followed by asymmetric transamination to the L-amino acid. The rat can use the α-keto analogue of tryptophan for growth, but this compound is not as effective as the amino acid itself (Pond et al., 1964).
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Young, S.N., Sourkes, T.L. (1977). Tryptophan in the central nervous system: Regulation and Significance. In: Agranoff, B.W., Aprison, M.H. (eds) Advances in Neurochemistry. Advances in Neurochemistry, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-8237-3_2
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