Actions of Opiates and Their Antagonists on Cholinergic Transmission in the Guinea Pig Ileum

  • Seymour Ehrenpreis


Ever since Paton (1957) and Schaumann (1957) developed techniques for electrical or transmural stimulation of the guinea pig ileum, this tissue has become a favorite tool for examining drug effects on parasympathetic [acetylcholine (Ach)] transmission. In particular the use of this preparation has greatly advanced knowledge of the mechanism of action of opiates as analgesics and addictive drugs. This chapter is a detailed discussion of the actions of various opiates and their antagonists on ilea from normal and addicted guinea pigs. Some new concepts for the molecular mechanism of action of opiates, the development of tolerance, and production of withdrawal symptoms will be suggested.


Longitudinal Muscle Opiate Receptor Cholinergic Transmission Transmural Stimulation Opiate Action 
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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • Seymour Ehrenpreis
    • 1
  1. 1.New York State Research Institute for Neurochemistry and Drug AddictionWard’s Island, New YorkUSA

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