“De Novo” Engineering of Peptide Immunogenic and Antigenic Determinants as Potential Vaccines

Kaumaya, Pravin T. P.; Kobs-Conrad, Susan; DiGeorge, Ann M.; Stevens, Vernon C.

doi:10.1007/978-1-4615-8176-5_9

Pravin T. P. Kaumaya,
Susan Kobs-Conrad,
Ann M. DiGeorge &
…
Vernon C. Stevens

155 Accesses
14 Citations

Abstract

In this chapter, we summarize some current approaches to the de novo design of structurally defined polypeptides with emphasis on their application to synthetic peptide vaccine development and review our attempts at engineering conformational peptides for vaccines. The purpose of this review is twofold:

1.
to briefly enumerate strategies of synthetic peptide design as it pertains to elucidating and mapping B-cell antigenic determinants, and
2.
to view this field, and specifically synthetic vaccines from design principles and perspectives, as it relates to the topographic nature of antigenic sites recognized by B cells.

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Pravin T. P. Kaumaya
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Susan Kobs-Conrad
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Ann M. DiGeorge
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Vernon C. Stevens
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Editors and Affiliations

Novabiochem USA, 10394 Pacific Center Court, San Diego, CA, 92127, USA
Channa Basava
Atherosclerosis Research Unit, Department of Medicine, The University of Alabama at Birmingham, University Station, DREB 640, Birmingham, AL, 35924-0012, USA
G. M. Anantharamaiah

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Kaumaya, P.T.P., Kobs-Conrad, S., DiGeorge, A.M., Stevens, V.C. (1994). “De Novo” Engineering of Peptide Immunogenic and Antigenic Determinants as Potential Vaccines. In: Basava, C., Anantharamaiah, G.M. (eds) Peptides. Birkhäuser Boston. https://doi.org/10.1007/978-1-4615-8176-5_9

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