Calcitonin: A Minireview

Basava, Channa

doi:10.1007/978-1-4615-8176-5_13

Channa Basava

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2 Citations

Abstract

Calcitonin (CT) is a 32-amino-acid, single-chain polypeptide hormone that plays important roles in calcium homeostasis and bone remodeling. Endogenous calcitonin is secreted primarily by the parafollicular cells referred to as the “C” cells. These cells are scattered throughout the thyroid in mammals but constitute a distinct organ, the ultimobranchial body, in submammalian species. The major biological function of calcitonin is to inhibit osteoclast-induced mineral resorption from bone. It regulates serum calcium concentrations by opposing the bone and renal effects of parathyroid hormone and by inhibiting bone resorption, resulting in hypocalcemia, hypophosphatemia, and decreased urinary calcium concentrations.

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Channa Basava
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Novabiochem USA, 10394 Pacific Center Court, San Diego, CA, 92127, USA
Channa Basava
Atherosclerosis Research Unit, Department of Medicine, The University of Alabama at Birmingham, University Station, DREB 640, Birmingham, AL, 35924-0012, USA
G. M. Anantharamaiah

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Basava, C. (1994). Calcitonin: A Minireview. In: Basava, C., Anantharamaiah, G.M. (eds) Peptides. Birkhäuser Boston. https://doi.org/10.1007/978-1-4615-8176-5_13

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DOI: https://doi.org/10.1007/978-1-4615-8176-5_13
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