Abstract
According to the calcium hypothesis of brain aging, abnormal intracellular calcium homeostasis has been proposed to be involved in the pathology of Alzheimer’s disease (AD) and multifarct dementia (MID). Since free intracellular calcium plays a key role in many cellular functions, imbalances in calcium regulation could finally lead to degeneration of neurons during aging and disease. Thus, pharmacological mechanisms controlling neuronal calcium homeostasis represent a major strategy for the development of new treatments of AD or other age-related disturbances of cognitive functions.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Adunsky A, Baram D, Hershkowitz M and Mekori YA (1991): Increased cytosolic free calcium in lymphocytes of Alzheimer patients. J Neuroirnrnunol 33: 167–172.
Bondy B, Klages U, Müller-Spahn F and Hock C (1994): Cytosolic free [Ca2+] in mononuclear blood cells from demented patients and healthy controls. Eur Arch Psychiatry Clin Neurosci 243: 224–228.
Eckert A, Hartmann H and Müller WE (1993a): Amyloid protein enhances the mitogen-induced calcium response in circulating human lymphocytes. FEES Lett 330: 49–52.
Eckert A, Förstl H, Hartmann H and Müller WE (1993b): Decreased ß-amyloid sensitivity in Alzheimer’s disease. Lancet 342: 805–806.
Eckert A, Hartmann H, Förstl H and Müller WE (1994a): Alterations of intracellular calcium regulation during aging and Alzheimer’s disease in non-neuronal cells. Life Sci (In Press).
Eckert A, Förstl H, Hartmann H, Czech C, Mönning U, Beyreuther K and Müller WE (1994b): The amplifying effect of ß-amyloid on cellular calcium signalling is reduced in Alzheimer’s disease: possible relationship to apolipoprotein E polymorphism (Submitted).
Etcheberrigaray R, Ito E, Oka K, Tofel-Grehl B, Gibson GE and Alkon DL (1993): Potassium channel dysfunction in fibroblasts identifies patients with Alzheimer’s disease. Proc Natl Aca Sci USA 90: 8209–8213.
Gibson GE and Peterson C (1987): Calcium and the aging nervous system. Neurobiol Aging 8: 329–343.
Hartmann H and Müller WE (1993): Age-related changes in receptor-mediated and depolarization-induced phosphatidylinositol turnover in mouse brain. Brain Res 622: 86–92.
Hartmann H, Eckert A and Müller WE (1993a): Aging enhances the calcium sensitivity of central neurons of the mouse as an adaptive response to reduced free intracellular calcium. Neurosci Lett 152: 181–184.
Hartmann H, Eckert A and Müller WE (1993b): Amyloid protein amplifies calcium signalling in central neurons from the adult mouse. Biochem Biophys Res Commun 194: 1216–1220.
Hartmann H, Eckert A and Müller WE (1994a): Similar age-related changes of free intracellular calcium in lymphocytes and central neurons: effects of Alzheimer’s disease. Eur Arch Psychiatry Clin Neurosci 243: 218–223.
Hartmann H, Eckert A and Müller WE (1994b): Apolipoprotein E and cholesterol affect neuronal calcium signalling. The possible relationship to ß-amyloid neurotoxicity. Biochem Biophys Res Comm 200: 1185–1192.
Huang HM, Toral-Borza L, Thaler H, Tofel-Grehl B and Gibson GE (1991): Inositol phosphates and intracellular calcium after bradykinin stimulation in fibroblasts from young, aged and Alzheimer’s donors. Neurobiol Aging 2: 469–473.
Mason RP, Shopemaker WJ, Shajenko L, Chambers TE and Herbette LG (1992): Evidence for changes in the Alzheimer’s disease brain cortical membrane structure mediated by cholesterol. Neurobiol Aging 13: 413–419.
Mattson MP, Cheng B, Davies D, Bryant K, Lieberburg I and Rydel RE (1992): ßamyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to exocitotoxicity. J Neurosci 12: 376–389.
Peterson C, Rattan RR, Shelanski ML and Goldman JE (1986): Cytosolic free calcium and cell spreading decrease in fibroblasts from aged and Alzheimer donors. Proc Natl Acad Sci USA 83: 7999–8001.
Toth S, Csermely P, Beregi E, Szkladanyi and Szabo LD (1989): Decreased cytosolic free calcium concentration of aged human lymphocytes in resting state. Compr Gerontol Suppl Issue A+B 3: 16–22.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1994 Birkhäuser Boston
About this paper
Cite this paper
Müller, W., Eckert, A., Hartmann, H., Förstl, H. (1994). Free Intracellular Calcium in Aging and Alzheimer’s Disease. In: Giacobini, E., Becker, R.E. (eds) Alzheimer Disease. Advances in Alzheimer Disease Therapy. Birkhäuser Boston. https://doi.org/10.1007/978-1-4615-8149-9_50
Download citation
DOI: https://doi.org/10.1007/978-1-4615-8149-9_50
Publisher Name: Birkhäuser Boston
Print ISBN: 978-1-4615-8151-2
Online ISBN: 978-1-4615-8149-9
eBook Packages: Springer Book Archive