Abstract
Apolipoprotein E (apoE) is a well-characterized lipophilic protein associated with plasma and CSF lipoproteins. Apolipoprotein E is synthesized primarily by the liver, but also at other sites including brain, macrophages and adrenals (Elshourbagy et al., 1985). Furthermore, apoE is unique among apolipoproteins in that it has a special relevance to the central and peripheral nervous systems. It is a key determinant in the cellular recognition and internalization of cholesterol-and phospholipid-rich lipoproteins in the developing brain and in the response to neuronal injury (Boyles et al., 1989; Poirier et al., 1991a,b, 1993a). It was shown to play a fundamental role in the CNS during hippocampal synaptic plasticity induced by entorhinal cortex lesions in the rat (Poirier et al., 1991a,b, 1993).
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© 1994 Birkhäuser Boston
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Poirier, J., Aubert, I., Bertrand, P., Quirion, R., Gauthier, S., Nalbantoglu, J. (1994). Apolipoprotein E4 and Cholinergic Dysfunction in Alzheimer’s Disease. In: Giacobini, E., Becker, R.E. (eds) Alzheimer Disease. Advances in Alzheimer Disease Therapy. Birkhäuser Boston. https://doi.org/10.1007/978-1-4615-8149-9_12
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DOI: https://doi.org/10.1007/978-1-4615-8149-9_12
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Print ISBN: 978-1-4615-8151-2
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