Vasopressin pp 117-174 | Cite as

Development of Vasopressin Systems and Their Functions

  • G. J. Boer


Studies on the morphology and function of vasopressin (VP)-synthesizing cells during ontogeny have focused on the hypothalamus-neurohypophysial system (HNS), especially in the rat. In the past decade, as a result of new immunocyto-chemical techniques in particular, but also because of increasing knowledge about the biochemistry of the adult HNS (see Chapter 4, this volume), much has been added to our understanding of the development of this system. Its functional capacity during parturition and in the regulation of fluid and electrolyte homeostasis perinatally has also received a great deal of attention, since sensitive and specific radioimmunoassays (RIAs) have permitted the detection of small amounts of VP. Part of the interest in this field can be explained by the fact that the HNS is a well-defined neuroendocrine system (see Chapter 1, this volume) that serves as an excellent model for the description of developmental mechanisms in the central nervous system (CNS). Furthermore, grafting studies with fetal hypothalamus tissue were recently introduced as a tool in exploring the plasticity and integration of developing VP cells.


Median Eminence Suprachiasmatic Nucleus Lateral Septum External Zone Magnocellular Neuron 
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • G. J. Boer
    • 1
  1. 1.Netherlands Institute for Brain ResearchAmsterdam ZOThe Netherlands

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