Skip to main content

Cardiovascular Actions of Vasopressin

  • Chapter
Vasopressin

Abstract

Although the cardiovascular actions of vasopressin (VP) have been examined systematically only in recent years, Oliver and Schafer (1895) first observed the vaso-pressor activity of pituitary gland extracts in 1895. This was soon confirmed by three other investigators (Howell, 1898; Livon, 1898; von Cyon, 1898) and Howell demonstrated that the pressor principle resided in extracts of the posterior lobe. It was from these early observations that VP derived its name. The antidi-uretic actions of VP were not observed until 1913, when two physicians working independently, Farini (1913), in Italy, and Von den Velden (1913), in Germany, reported successful treatment of patients with diabetes insipidus by injections of posterior pituitary extracts. With the 1924 demonstration of the antidiuretic effects of posterior pituitary extracts on the isolated kidney by Starling and Verney (1924), the antiduretic role of the neurohypophysis became the predominant aspect of interest related to VP. It became clear that this hormone was of vital importance for the conservation of body fluids and that, although pressor activity was widely observed, it was evident that these actions required amounts far in excess of those required for maximal antidiuretic activity (Saameli, 1968; Sawyer, 1971; Nakano, 1974). These important antidiuretic actions of VP are reviewed in Chapter 9.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

eBook
USD 9.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  • Abe, H., Inoue, M., Matsuo, T., and Ogata, N., 1983, The effects of vasopressin on electrical activity in the guinea-pig supraoptic nucleus in vitro, J. Physiol. (Lond.) 337: 665–685.

    CAS  Google Scholar 

  • Aisenbrey, G. A., Handelman, W. A., Arnold, P., Manning, M., and Schrier, R. W., 1981, Vascular effects of arginine vasopressin during fluid deprivation in the rat, J. Clin. Invest. 67: 961–968.

    PubMed  CAS  Google Scholar 

  • Akatsuka, N., Moran, W. H., Morgan, M. L., and Wilson, M. F., 1977, Effects of steady state plasma vasopressin levels on the distribution of intrarenal blood flow on electrolyte excretion, J. Physiol. (Lond). 266: 567–586.

    CAS  Google Scholar 

  • Altura, B. M., 1970, Significance of amino acid residues in vasopressin on contraction of vascular muscle, Am. J. Physiol. 219: 222–229.

    PubMed  CAS  Google Scholar 

  • Altura, B. M., 1975, Dose-response relationship for arginine vasopressin and synthetic analogs on three types of rat blood vessels: Possible evidence for regional differences in vasopressin receptor sites within a mammal, J. Pharmacol. Exp. Ther. 193: 413–423.

    PubMed  CAS  Google Scholar 

  • Altura, B. M., 1976a, DPAVP: A vasopressin analog with selective microvascular and RES actions for the treatment of circulatory shock in rats, Eur. J. Pharmacol. 37: 155–167.

    PubMed  CAS  Google Scholar 

  • Altura, B. M., 1976b, Microcirculatory approach to the treatment of circulatory shock with a new analog of vasopressin (2-phenylalanine, 8-ornithine) vasopressin, J. Pharmacol. Exp. Ther. 198: 187–196.

    PubMed  CAS  Google Scholar 

  • Altura, B. M., 1977, Comparative cellular and pharmacologie actions of neurohypophysial hormones on smooth muscle, Fed. Proc. 36: 1840–1841.

    PubMed  CAS  Google Scholar 

  • Altura, B. M., 1978, Humoral, hormonal, and myogenic mechanisms in microcirculatory regulation, in: Microcirculation, Vol. II (G. Kaley and B. M. Altura, eds.), pp. 431–502, University Park Press, Baltimore.

    Google Scholar 

  • Altura, B. M., 1980, Evidence that endogenous vasopressin plays a role in circulatory shock. Role for reticuloendothelial system using Brattleboro rats, Experientia 36: 1080–1081.

    PubMed  CAS  Google Scholar 

  • Altura, B. M., and Altura, B. T., 1977, Vascular smooth muscle and neurohypophysial hormones, Fed. Proc. 36: 1853–1860.

    PubMed  CAS  Google Scholar 

  • Altura, B. M., Hershey, S. G., and Zweifach, B. W., 1965, Effects of a synthetic analogue vasopressin on vascular smooth muscle, Proc. Soc. Exp. Biol. Med. 119: 258–261.

    PubMed  CAS  Google Scholar 

  • Andrews, C. E., and Brenner, B. M., 1981, Relative contributions of arginine vasopressin and angio-tensin II to maintenance of systemic arterial pressure in the anesthetized water-deprived rat, Circ. Res. 48: 254–258.

    PubMed  CAS  Google Scholar 

  • Ang, V. T. Y., and Jenkins, J. S., 1982, Blood-cerebrospinal fluid barrier to arginine-vasopressin, desmopressin and deglycinamide arginine-vasopressin in the dog, J. Endocrinol. 93: 319–325.

    PubMed  CAS  Google Scholar 

  • Antoni, F. A., 1984, Characterization of high affinity binding sites for vasopressin in bovine adrenal medulla, Neuropeptides 4: 413–420.

    PubMed  CAS  Google Scholar 

  • Arnauld, E., Czernichow, P., Fumoux, F., and Vincent, J.-D., 1977, The effects of hypotension and hypovolaemia on the liberation of vasopressin during haemorrhage in the unaenesthetized monkey, Pflugers Arch. 371: 193–200.

    PubMed  CAS  Google Scholar 

  • Banks, F. O., 1976, Influence of antidiuretic hormone on intrarenal blood flow distribution in diabetes insipidus dogs and rats, Proc. Soc. Exp. Biol. Med. 151: 547–551.

    PubMed  CAS  Google Scholar 

  • Bartelstone, H. J. and Nasmyth, P. A., 1965, Vasopressin potentiation of catecholamine actions in dog, rat, cat, and rat aortic strip, Am. J. Physiol. 208: 754–762.

    PubMed  CAS  Google Scholar 

  • Beijer, H. J. M., Maas, A. H. J., and Charbon, G. A., 1984, A vasopressin-induced decrease in pancreatic blood flow and in pancreatic exocrine secretion in the anesthetized dog, Pflugers Arch. 400: 324–328.

    PubMed  CAS  Google Scholar 

  • Berde, B., and Boissonnas, R. A., 1968, Basic pharmacological properties of synthetic analogues and homologues of the neurohypophysial hormones, in: Handbook of Experimental Pharmacology. Neurohypophysial Hormones and Similar Polypeptides (B. Berde, ed.), pp. 802–870, Springer-Verlag, Heidelberg.

    Google Scholar 

  • Berecek, K. H., Stocker, M., and Gross, F., 1980, Changes in renal vascular reactivity at various states of deoxycorticosterone hypertension in rats, Circulation 46: 619–624.

    CAS  Google Scholar 

  • Berecek, K. H., Barron, K. W., Webb, R. L., and Brody, M. J., 1982a, Vasopressin-central nervous system interactions in the development of DOCA hypertension, Hypertension 4(Suppl. II): 131–137.

    PubMed  CAS  Google Scholar 

  • Berecek, K. H., Murray, R. D., Gross, F., and Brody, M. J., 1982b, Vasopressin and vascular reactivity in the development of DOCA hypertension in rats with hereditary diabetes insipidus, Hypertension 4: 3–12.

    PubMed  CAS  Google Scholar 

  • Berecek, K. H., Webb, R. L., and Brody, M. J., 1982c, relationship between vasopressin and the anter-oventral third ventricle region in deoxycorticosterone/salt hypertension (Brattleboro rat model), in: The Brattleboro Rat (H. W. Sokol and H. Valtin, eds.), pp. 392–397, The New York Academy of Sciences, New York.

    Google Scholar 

  • Berecek, K. H., Webb, R. L., and Brody, M. J., 1983, Evidence for a central role for vasopressin in cardiovascular regulation, Am. J. Physiol. 244: H852–H859.

    PubMed  CAS  Google Scholar 

  • Bie, P., and Warberg, J., 1983, Effects on intravascular pressures of vasopressin and angiotensin II in dogs, Am. J. Physiol. 245:R906-R914.

    Google Scholar 

  • Blei, A. T., Groszmann, R. J., Gusberg, R., and Conn, H. O., 1980, Comparison of vasopressin and triglycyllysine vasopressin on splanchnic and systemic hemodynamics in dogs. Dig. Dis. Sci. 25: 688–694.

    PubMed  CAS  Google Scholar 

  • Blessing, W. W., Sved, A. F., and Reis, D. J., 1982, Elevated plasma vasopressin contributes to fulminating hypertension produced by functional impairment of AI catecholamine neurons in rabbit medulla, Clin. Sci. 63: 289s–292s.

    Google Scholar 

  • Bohus, B., Versteeg, C. A. M., deJohn, W., Cransberg, K., and Kooky, J. G., 1983, Neurohypophysial hormones and central cardiovascular control, in: The Neurohypophysis: Structure, Function and Control. Progress in Brain Research, Vol. 60 (B. A. Cross and G. Leng, eds.), pp. 445–457, Elsevier, Amsterdam.

    Google Scholar 

  • Brackett, D. J., Schaefer, C. F., and Wilson, M. F., 1983, The role of vasopressin in the maintenance of cardiovascular function during early endotoxin shock, in: Advances in Shock Research, Vol. 9 (S. M. Reichard, ed.), pp. 147–156, Alan R. Liss, New York.

    Google Scholar 

  • Brunner, D. B., Burnier, M., and Brunner, H. R., 1983, Plasma vasopressin in rats: Effect of sodium, angiotensin, and catecholamines, Am. J. Physiol. 244:H259-H265.

    Google Scholar 

  • Burnier, M., and Brunner, H. R., 1983, Pressor responses of rats to vasopressin: Effect of sodium, angiotensin, and catecholamines, Am. J. Physiol. 244:H253-H258.

    Google Scholar 

  • Burnier, M, Biollaz, J., Brunner, D. B., and Brunner, H. R., 1983, Blood pressure maintenance in awake dehydrated rats: Renin, vasopressin, and sympathetic activity, Am. J. Physiol. 245: H203–H209.

    PubMed  CAS  Google Scholar 

  • Byrom, F. B., 1939, Morbid effects of vasopressin on the organs and vessels of rats, J. Pathol. 45: 1–15.

    Google Scholar 

  • Ciriello, J., and Calaresu, F. R., 1980, Role of paraventricular and supraoptic nuclei in central cardiovascular regulation in the cat, Am. J. Physiol. 239: R137–R142.

    PubMed  CAS  Google Scholar 

  • Coleman, R. J., and Reppert, S. M., 1985, CSF vasopressin rhythm is effectively insulated from osmotic regulation of plasma vasopressin. Am. J. Physiol. 248: E346–E352.

    PubMed  CAS  Google Scholar 

  • Collis, M. G., 1981, Vascular reactivity to vasopressin in DOCA-salt hypertensive rats, J. Pharm. Pharmacol. 33: 468–469.

    PubMed  CAS  Google Scholar 

  • Commarato, M. A., and Lum, B. K. B., 1969, Cardiovascular interactions of amphetamine and ephed-rine with norepinephrine and with vasopressin, Eur. J. Pharmacol. 7: 125–134.

    PubMed  CAS  Google Scholar 

  • Cort, J. H., Jeanjean, M. F., Thomson, A. E., and Nickerson, M., 1968, Effect of “hormonogen” forms of neurohypophysial peptides in hemorrhagic shock in dogs, Am. J. Physiol. 214: 455–462.

    PubMed  CAS  Google Scholar 

  • Cort, J. H., Fischman, A. J., Dodds, W. J., Rand, J. H., and Schwartz, I. L. 1981, New category of vasopressin receptor in the central nervous system. Evidence that this receptor mediates the release of a humoral factor VIII-mobilizing principle, Int. J. Pept. Protein, Res. 17: 14–22.

    CAS  Google Scholar 

  • Cowley, A. W., Jr., 1978, Perspectives on the physiology of hypertension, in: Hypertension: Mechanisms, Diagnosis and Treatment (G. Onesti and A. N. Brest, eds.), pp. 1–22, F. A. Davis, Philadelphia.

    Google Scholar 

  • Cowley, A. W., Jr., 1982, Vasopressin and cardiovascular regulation, in: Cardiovascular Physiology, Vol. 4: International Review of Physiology, Vol. 26 (A. C. Guyton and J. E., Hall, eds.), pp. 189–242, University Park Press, Baltimore.

    Google Scholar 

  • Cowley, A. W., Jr., and Barber, B. J., 1983, Vasopressin vascular and reflex effects—A theoretical analysis, in: The Neurohypophysis. Structure, Function and Control. Progress in Brain Research, Vol. 60 (B. A., Cross and G. Leng, eds.), pp. 415–424, Elsevier, Amsterdam.

    Google Scholar 

  • Cowley, A. W., Jr., and DeClue, J. W., 1976, Quantification of baroreceptor influence on arterial pressure changes seen in primary angiotensin-induced hypertension in dogs, Circ. Res. 39: 779–787.

    PubMed  CAS  Google Scholar 

  • Cowley, A. W., Jr., and Guyton, A. C., 1972, Quantification of intermediate steps in the renin-angio-tensin-vasoconstrictor feedback loop in the dog, Circ. Res. 30: 557–566.

    PubMed  CAS  Google Scholar 

  • Cowley, A. W., Jr., Monos, E., and Guyton, A. G, 1974, Interaction of vasopressin and the baroreceptor reflex system in the regulation of arterial blood pressure in the dog, Circ. Res. 34: 505–514.

    PubMed  CAS  Google Scholar 

  • Cowley, A. W., Jr., Switzer, S. J., and Guinn, M. M., 1980, Evidence and quantification of the vasopressin arterial pressure control system in the dog, Circ. Res. 46: 58–67.

    PubMed  CAS  Google Scholar 

  • Cowley, A. W., Jr., Cushman, W. C., Quillen, E. W., Jr., Skelton, M. M, and Langford, H. G., 1981a, Vasopressin elevation in essential hypertension and increased responsiveness to sodium intake, Hypertension 3(Suppl I): 93–100.

    CAS  Google Scholar 

  • Cowley, A. W., Jr., Switzer, S. J., and Skelton, M. M, 1981b, Vasopressin, fluid, and electrolyte response to chronic angiotensin II infusion, Am. J. Physiol. 240: R130–R138.

    PubMed  CAS  Google Scholar 

  • Cowley, A. W., Jr., Merrill, D. G, Quillen, E. W., Jr., and Skelton, M. M., 1984a, Long-term blood pressure and metabolic effects of vasopressin with servo-controlled fluid volume, Am. J. Physiol. 247: R537–R545.

    PubMed  CAS  Google Scholar 

  • Cowley, A. W., Jr., Merrill, D. G, Osborn, J., and Barber, B. J., 1984b, Influence of vasopressin and angiotensin on baroreflexes in the dog, Circ. Res. 54: 163–172.

    PubMed  CAS  Google Scholar 

  • Cowley, A. W., Jr., Liard, J. F., Skelton, M. M., Quillen, E. W., Jr., Osborn, J. W., Jr., and Webb, R. L., 1985a, Vasopressin-neural interactions in the control of cardiovascular function, in: Vasopressin (Robert W. Schrier, ed.), pp. 1–10 Raven, New York.

    Google Scholar 

  • Cowley, A. W., Jr., Skelton, M. M., and Velasquez, M. T., 1985b, Sex differences in the endocrine predictors of essential hypertension: Vasopressin versus renin, Hypertension 7(Suppl. I): 151–160.

    Google Scholar 

  • Crause, P., Boer, R., and Fahrenholz, F., 1984, Determination of the functional molecular size of vasopressin isoreceptors, FEBS Lett. 175: 383–386.

    PubMed  CAS  Google Scholar 

  • Cristoforo, M. F., and Brody, M. J., 1968, Non-adrenergic vasoconstriction produced by halothane and cyclo-propane anesthesia, Anesthesiology 29: 44–56.

    PubMed  CAS  Google Scholar 

  • Crofton, J. T., Share, L., Shade, R. E., Allen G, and Tarnowski, D., 1978, Vasopressin in the rat with spontaneous hypertension, Am. J. Physiol. 235: H361–H366.

    PubMed  CAS  Google Scholar 

  • Crofton, J. T., Share, L., Shade, R. E., Lee-Kwon, W. J., Manning, M., and Sawyer, W. H., 1979, The importance of vasopressin in the development and maintenance of DOC-salt hypertension in the rat, Hypertension 1: 31–38.

    PubMed  CAS  Google Scholar 

  • Crofton, J. T., Share, L., Wang, B. C., and Shade, R. E., 1980, Pressor responsiveness to vasopressin in the rat with DOC-salt hypertension, Hypertension 2: 424–431.

    PubMed  CAS  Google Scholar 

  • Crofton, J. T., Share, L., Baer, P. G., Allen, C. M., and Wang, B. C., 1981, Vasopressin secretion in the New Zealand genetically hypertensive rat, Clin. Exp. Hypertens. 3: 975–989.

    PubMed  CAS  Google Scholar 

  • De Jong, W., Versteeg, C. A. M., and Bohus, B., 1984, Inhibition of pressor responses induced by electrical stimulation of the mesencephalon by vasopressin and oxytocin, Clin. Exp. Hypertens. A6: 139–147.

    Google Scholar 

  • De Vries, G. J., Buijs, R. M., Van Leeuwen, F. W., Caffe, A. R., and Swaab, D.J., 1985, The vaso-pressinergic innervation of the brain in normal and castrated rats, J. Comp. Neurol. 233: 236–254.

    Google Scholar 

  • De Wied, D., Bohus, B., and Van Wimersma Reidanus, T., 1975, Memory deficit in rats with hereditary diabetes insipidus, Brain Res. 85: 152–156.

    Google Scholar 

  • Del Bo, A., Sved, A. F., and Reis, D. J., 1983, Fastigial stimulation releases vasopressin in amounts that elevate arterial pressure, Am. J. Physiol. 244: H687–H694.

    PubMed  Google Scholar 

  • Dicker, S. E., 1953, A method for the assay of very small amounts of antidiuretic activity with a note on the antidiuretic titre of rats’ blood, J. Physiol. (Lond.) 122: 149–157.

    CAS  Google Scholar 

  • DiPette, D. J., Gavras, L, North, W. G., Brunner, H. R., and Gavras, H., 1982, Vasopressin in salt-induced hypertension of experimental renal insufficiency, Hypertension 4(Suppl. II): 25–30.

    Google Scholar 

  • Dogterom, J., and Buijs, R. M., 1980, Vasopressin and oxytocin distribution in rat brain: Radioim-munoassay and immunocytochemical studies, in: Neuropeptides and Neural Transmission, Vol. 7 (C. A., Marsan and W. Z. Traczyk, eds.), pp. 307–314, Raven, New York.

    Google Scholar 

  • Doris, P. A., and Bell, F. R., 1984, Vasopressin in plasma cerebrospinal fluid of hydrated and dehydrated steers, Neuroendocrinology 38: 290–296.

    PubMed  CAS  Google Scholar 

  • Drapanas, T., Crowe, C. P., Shim, W. K. T., and Schenk, W. G., 1961, The effect of pitressin on cardiac output and coronary, hepatic, and intestinal blood flow. Surg. Gynecol. Obstet. 113: 484–489.

    PubMed  CAS  Google Scholar 

  • du Vigneaud, V., Lawler, H. C., and Popenoe, E. A., 1953, Enzymatic cleavage of glycinamide from vasopressin and a proposed structure for this pressor-antidiuretic hormone of the posterior pituitary, J. Am. Chem. Soc. 75: 4880–4881.

    Google Scholar 

  • Dunn, F. L., Brennan, T. J., Nelson, A. E., and Robertson, G. L., 1973, The role of blood osmolality and volume in regulating vasopressin secretion in the rat, J. Clin. Invest. 52: 3213–3219.

    Google Scholar 

  • Ebert, T. J., Cowley, A. W., and Skelton, M., 1986, Vasopressin reduces cardiac function and augments cardiopulmonary baroreflex resistance increases in man, J. Clin. Invest. 77: 1136-142.

    Google Scholar 

  • Elijovich, F., Barry, C. R., Krakoff, L. R., and Kirchberger, M., 1984, Differential effect of vasopressin on angiotensin and norepinephrine pressor action in rats, Am. J. Physiol. 247: H973–H977.

    PubMed  CAS  Google Scholar 

  • Elliott, J. M., West, M. J., and Chalmers, J., 1985, Effects of vasopressin on heart rate in conscious rabbits, J. Cardiovasc. Pharmacol. 7: 6–11.

    PubMed  CAS  Google Scholar 

  • Ellis, M. E., and Grollman, A., 1949, The antidiuretic hormone in the urine in experimental and clinical hypertension, Endocrinology 44: 415–419.

    PubMed  CAS  Google Scholar 

  • Ericsson, B. F., 1971, Effect of vasopressin on the distribution of cardiac output and organ blood flow in the anesthetized dog. Acta Chir. Scand. 137: 729–738.

    PubMed  CAS  Google Scholar 

  • Ericsson, B. F., 1972, The effect of vasopressin on the distribution of cardiac output in the early phase of haemorrhagic shock in the anesthetized dog, Acta Chir. Scand. 138: 119–123.

    PubMed  CAS  Google Scholar 

  • Errington, M. L., and Rochae Silva, M., 1974, On the role of vasopressin and angiotensin in the development of irreversible haemorrhagic shock, J. Physiol. (Lond.) 242: 119–141.

    CAS  Google Scholar 

  • Farini, F., 1913, Diabete insipido ed opoterapia, Gazz. Osped. Clin. 34: 1135–1139.

    Google Scholar 

  • Fejes-Toth, G., Fekete, A., and Walter, J., 1978, Effect of antidiuretic hormone and indomethacin on intrarenal microsphere distribution, Pflugers Arch. 376: 67–72.

    PubMed  CAS  Google Scholar 

  • Frieden, J., and Keller, A. D., 1954, The release of vasopressin in response to haemorrhage and its role in the mechanism of blood pressure regulation, Circ. Res. 2: 214–220.

    PubMed  CAS  Google Scholar 

  • Friedman, S. M, Friedman, C. L., and Nakashima, M., 1960, Accelerated appearance of DOCA hypertension in rats treated with pitressin, Endocrinology 67: 752–759.

    PubMed  CAS  Google Scholar 

  • Ganten, U., Rascher, W., Lang, R. E., Dietz, R., Rettig, R., Unger, T., Taugner, R., and Ganten, D., 1983, Development of a new strain of spontaneously hypertensive rats homozygous for hypotha-lamic diabetes insipidus, Hypertension 5(Suppl. I): 119–128.

    Google Scholar 

  • Gardiner, S. M., and Bennett, T., 1982, The control of heart in rats with hereditary hypothalamic diabetes insipidus (Brattleboro strain), in The Brattleboro Rat (H. W., Sokol and H. Valtin, eds.), pp. 363–374, Annals of the New York Academy of Science, New York.

    Google Scholar 

  • Gardiner, S. M., and Bennett, T., 1983, The cardiovascular and renal responses to short-term isolation in Brattleboro rats, Clin. Sci. 64: 377–382.

    PubMed  CAS  Google Scholar 

  • Garvas, H., Hatsinikolaou, P., North, W. G., Breshnahan, M., and Gavras, I., 1982, Interaction of the sympathetic nervous system with vasopressin and renin in the maintenance of blood pressure, Hypertension 4: 400–405.

    Google Scholar 

  • Gerke, D. C., Frewin, D. B., and Frost, B. R., 1977, The synergistic vasoconstrictor effect of octapressin and catecholamines on the isolated rabbit ear artery, Aust. J. Exp. Biol. Med. Sci. 55: 737–740.

    PubMed  CAS  Google Scholar 

  • Gilbey, M. P., Coote, J. H., Fleetwood-Walker, S., and Peterson, D. F., 1982, The influence of the paraventriculo-spinal pathway, and oxytocin and vasopressin on sympathetic preganglionic neurons, Brain Res. 251: 283–290.

    PubMed  CAS  Google Scholar 

  • Ginsburg, M., and Brown, L. M., 1956, Effect of anaesthetics and haemorrhage on the release of neurohypophysial antidiuretic, Br. J. Pharmacol. 11: 236–244.

    CAS  Google Scholar 

  • Goodman, L. S., and Gilman, A., 1955, The Pharmacological Basis of Therapeutics, Macmillan, New York.

    Google Scholar 

  • Gross, P. A., Travis, V. L., Horwitz, L., Schrier, R. W., and Anderson, R. J., 1982, Effect of desmo-pressin-induced water retention on systemic hemodynamics in rat, Am. J. Physiol. 243: H934–H940.

    PubMed  CAS  Google Scholar 

  • Guo, G. B., Sharabi, F. M., Abboud, F. M., and Schmid, P. G., 1982, Vasopressin augments baroreflex inhibition of lumbar sympathetic nerve activity in rabbits, Circulation 66(Suppl. II): 34.

    Google Scholar 

  • Guyton, A. C., Coleman, T. G., Cowley, A. W., Jr., Scheel, K. W., Manning, R. D., Jr., and Norman, R. A., Jr., 1972, Arterial pressure regulation: Overriding dominance of the kidney in long-term regulation and in hypertension, Am. J. Med. 52: 584–594.

    PubMed  CAS  Google Scholar 

  • Haack, D., and Mohring, J., 1978, Vasopressin-mediated blood pressure response to intraventricular injection of angiotensin II in the rat, Pflugers Arch. 373: 167–173.

    PubMed  CAS  Google Scholar 

  • Hanley, M. R., Benton, H. P., Lightman, S. L., Todd, K., Bone, E. A., Fretten, P., Palmer, S., and Kirk, C. J., 1984, A vasopressin-like peptide in the mammalian sympathetic nervous system, Nature (Lond.) 309: 258–261.

    CAS  Google Scholar 

  • Harris, M. C., Bands, D., and Zerihun, L., 1982, Inputs from hypothalamic paraventricular nucleus to dorsal medullary nuclei in the rat, in: Neuroendocrinology of Vasopressin, Corticoliberin and Opiomelanocortins (A. J. Baertschi and J. J. Dreifuss, eds.), pp. 153–165, Academic, London.

    Google Scholar 

  • Hatzinikolaou, P., Garvas, H., Brunner, H. R., and Gavras, I., 1980, Sodium-induced elevation of blood pressure in the anephric state, Science 209: 935–936.

    PubMed  CAS  Google Scholar 

  • Hatzinikolaou, P., Gavras, H., Brunner, H. R., and Gavras, I., 1981, Role of vasopressin, catechola-mines, and plasma volume in hypertonic saline-induced hypertension, Am. J. Physiol. 240: H827–H831.

    PubMed  CAS  Google Scholar 

  • Hatzinikolaou, P., Gavras, L, North, W. G., Brunner, H. R., and Gavras, H., 1982, Interaction of the sympathetic nervous system with vasopressin and renin in the maintenance of blood pressure in rats, Clin. Sci. 63: 313s–317s.

    Google Scholar 

  • Heyndrickx, G. R., Boettcher, D. H., and Vatner, S. F., 1976, Effects of angiotensin, vasopressin, and methoxamine on cardiac function and blood flow distribution in conscious dogs, Am. J. Physiol. 231: 1579–1587.

    PubMed  CAS  Google Scholar 

  • Hinojosa, C., and Haywood, J. R., 1984, Contribution of vasopressin and the sympathetic nervous system in the early phase of high sodium one-kidney renal hypertension, Hypertension 6: 848–854.

    PubMed  CAS  Google Scholar 

  • Hock, C. E., Su, J. Y., and Lefer, A. M., 1984, Role of AVP in maintenance of circulatory homeostasis during hemorrhagic shock, Am. J. Physiol. 246: H174–H179.

    PubMed  CAS  Google Scholar 

  • Hofbauer, K. G., Konrads, A., Bauereiss, K., Mohring, B., Mohring, J., and Gross, F., 1977, Vasopressin and renin in glycerol-induced acute renal failure in the rat, Circ. Res. 41: 424–428.

    PubMed  CAS  Google Scholar 

  • Hofbauer, K. G., Forgiarini, P., and Kerr, F., 1982, Vasopressin receptor blockade and converting enzyme inhibition in glycerol-induced acute renal failure in rats, in: Acute Renal Failure (D. Seybold, ed.), pp. 139–151, S. Karger, Basel.

    Google Scholar 

  • Hofbauer, K. G., Mah, S. C., Baum, H.-P., Hanni, H., Wood, J. M., and Kraitz, J., 1984, Endocrine control of salt and water excretion: The role of vasopressin in DOCA-salt hypertension, J. Cardiovasc. Pharmacol. 6: S184–S191.

    PubMed  Google Scholar 

  • Hoffman, W. E., 1980, Regional vascular effects of antidiuretic hormone in normal and sympathetic blocked rats, Endocrinology 107: 334–341.

    PubMed  CAS  Google Scholar 

  • Howell, W. H., 1898, The physiological effects of extracts of the hypophysis cerebri and infundibular body, J. Exp. Med. 3: 245–258.

    PubMed  CAS  Google Scholar 

  • Husain, M. K., Fernando, N., Shapiro, J., Kagan, A., and Glick, S. M., 1973, Radioimmunoassay of arginine vasopressin in human plasma, J. Clin. Endocrinol. Metab. 37: 616–625.

    PubMed  CAS  Google Scholar 

  • Husain, M. K., Fernando, N., Shapiro, M., Kagan, A., and Glick, S. M., 1979, Vasopressin release due to manual restraint in the rat: Role of body compression and comparison with other stressful stimuli, Endocrinology 104: 641–644.

    PubMed  CAS  Google Scholar 

  • Hutchinson, J. S., Schelling, P., Mohring, J., and Ganten, D., 1976, Pressor action of centrally perfused angiotensin II in rats with hereditary hypothalamic diabetes insipidus, Endocrinology 99: 819–823.

    PubMed  CAS  Google Scholar 

  • Imai, Y., Nolan, P. L., and Johnston, C. I., 1983, Restoration of suppressed baroreflex sensitivity in rats with hereditary diabetes insipidus (Brattleboro rats) by arginine-vasopressin and DDAVP, Circ. Res. 53: 140–149.

    PubMed  CAS  Google Scholar 

  • Ishikawa, S. E., and Schrier, R. W., 1984, Vascular effects of arginine vasopressin, angiotensin II, and norepinephrine in adrenal insufficiency, Am. J. Physiol. 246: H104–H113.

    PubMed  CAS  Google Scholar 

  • Ishikawa, S. E., Goldberg, J. P., Schrier, D. M., Aisenbrey, G. A., and Schrier, R. W., 1984, Interrelationships between subpressor effects of vasopressin and other vasoactive hormones in the rat, Mineral Electrolyte Metab. 10: 184–189.

    CAS  Google Scholar 

  • Iwamoto, H. S., Rudolph, A. M., Keil, L. C., and Heymann, M. A., 1979, Hemodynamic responses of the sheep fetus to vasopressin infusion, Circ. Res. 44: 430–436.

    PubMed  CAS  Google Scholar 

  • Izdebska, E., Jodkowski, J., and Trzebski, A., 1982, Central influence of vasopressin on baroreceptor reflex in normotensive rats and its lack in spontaneously hypertensive rats (SHR), Experientia 38: 594–595.

    PubMed  CAS  Google Scholar 

  • Jamison, R. L., and Kriz, W., 1982, Urinary Concentrating Mechanism: Structure and Function, Oxford University Press, New York.

    Google Scholar 

  • Jard, S., 1983, Vasopressin isoreceptors in mammals: relation to cyclic AMP-dependent and cyclic AMP-independent transduction mechanisms, in: Current Topics in Membranes and Transport, (A. Kleinzeller, ed.), pp. 255–285, Academic, New York.

    Google Scholar 

  • Karashima, T., 1981, Effects of vasopressin on smooth muscle cells of guinea-pig mesenteric vessels, Br. J. Pharmacol. 72: 673–684.

    PubMed  CAS  Google Scholar 

  • Katusic, Z. S., Shepherd, J. T., and Vanhoutte, P. M., 1984, Vasopressin causes endothelium-dependent relaxations of the canine basilar artery, Circ. Res. 55: 575–579.

    PubMed  CAS  Google Scholar 

  • Keil, L. C., and Severs, W. B., 1977, Reduction in plasma vasopressin levels of dehydrated rats following acute stress, Endocrinology 100: 30–38.

    PubMed  CAS  Google Scholar 

  • Kelly, R. T., Rose, J. C., Meis, P. J., Hargrave, B. Y., and Morris, M., 1983, Vasopressin is important for restoring cardiovascular homeostasis in fetal lambs subjected to hemorrhage, Am. J. Obstet. Gynecol. 146: 807–812.

    PubMed  CAS  Google Scholar 

  • Kepinow, D., 1912, Uber den Synergismus von Hypophysisextrakt und Adrenalin, Naunyn-Schmie-debergs Arch. Exp. Pathol. Pharmakol 67: 247–274.

    CAS  Google Scholar 

  • Khokhar, A. M., and Slater, J. D. H., 1976, Increased renal excretion of arginine-vasopressin during mild hydropenia in young men with mild essential benign hypertension, Clin. Sci. Mol. Med. 61:(Suppl.3): 691s–694s.

    Google Scholar 

  • Kline, R. L., Patel, K. P., and Mercer, P. F., 1984, Decrease in peripheral sympathetic activity of diabetes insipidus (DI) rats after vasopressin replacement, Fed. Proc. 43: 1067.

    Google Scholar 

  • Knepel, W., and Meyer, D. K., 1980, Influence of converting enzyme inhibition on the release of vasopressin induced by angiotensin, Br. J. Pharmacol. 71: 337–341.

    PubMed  CAS  Google Scholar 

  • Krogh, A., 1929, The Anatomy and Physiology of Capillaries, Yale University Press, New Haven, Connecticut.

    Google Scholar 

  • Lassoff, S., and Altura, B. M., 1980, Do pial terminal arterioles respond to local perivascular application of the neurohypophyseal peptide hormones, vasopressin and oxytocin?, Brain Res. 196: 266–269.

    PubMed  CAS  Google Scholar 

  • Laycock, J. F., Penn, W., Shirley, D. G., and Walter, S. J., 1979, The role of vasopressin in blood pressure regulation immediately following acute haemorrhage in the rat, J. Physiol. (Lond.) 296: 267–275.

    CAS  Google Scholar 

  • Lee-Kwon, W. J., Share, L., Crofton, J. T., and Shade, R. E., 1981, Vasopressin in the rat with partial nephrectomy-salt hypertension, Clin. Exp. Hypertens. 3: 281–297.

    PubMed  CAS  Google Scholar 

  • Liard, J. F., 1984, Atropine potentiates the pressor effect of arginine-vasopressin in conscious dogs, J. Cardiovasc. Pharmacol. 6: 867–871.

    PubMed  CAS  Google Scholar 

  • Liard, J. F., 1985, Effects of arginine vasopressin on regional circulations, in: Vasopressin (R. W. Schrier, ed.), pp. 59–67, Raven, New York.

    Google Scholar 

  • Liard, J. F., 1986, Cardiovascular effects associated with antidiuretic activity of vasopressin after blockade of its vasoconstrictor action in dehydrated dogs, Circ. Res. 58: 631–640.

    PubMed  CAS  Google Scholar 

  • Liard, J. F., and Spadone, J. G, 1984, Hemodynamic effects of antagonists of the vasoconstrictor action of vasopressin in conscious dogs, J. Cardiovasc. Pharmacol. 6: 713–719.

    PubMed  CAS  Google Scholar 

  • Liard, J. F., Deriaz, O., Tschopp, M., and Schoun, J., 1981, Cardiovascular effects of vasopressin infused into the vertebral circulation of conscious dogs. Clin. Sci. 61: 345–347.

    PubMed  CAS  Google Scholar 

  • Liard, J. F., Deriaz, O., Schelling, P., and Thibonnier, M., 1982, Cardiac output distribution during vasopressin infusion or dehydration in conscious dogs, Am. J. Physiol. 243: H663–H669.

    PubMed  CAS  Google Scholar 

  • Livon, C., 1898, Secretions internes, glandes hypertensives, J. Compt. Rendu Soc Biol. (Paris) 50: 98.

    Google Scholar 

  • Lluch, S., Conde, M. V., Dieguez, G., Lopez De Pablo, A. L., Gonzalez, M. C., Estrada, C., and Gomez, B., 1984, Evidence for the direct effect of vasopressin on human and goat cerebral arteries, J. Pharmacol Exp. Ther. 228: 749–755.

    PubMed  CAS  Google Scholar 

  • Lohmeier, T. E., Smith, M. J., Cowley, A. W., Jr., Manning, R. D., and Guyton, A. C., 1981, Is vasopressin an important hypertensive hormone? Hypertension 3: 416–425.

    PubMed  CAS  Google Scholar 

  • Luerssen, T. G., and Robertson, G. L., 1980, Cerebrospinal fluid vasopressin and vasotocin in health and disease, in: Neurobiology of Cerebrospinal Fluid (J. H. Wood, ed.), pp. 613–623, Plenum, New York.

    Google Scholar 

  • Lumbers, E. R., and Potter, E. K., 1982, The effects of vasoactive peptides on the carotid baroreflex, Clin. Exp. Pharmacol Physiol. (Suppl) 7: 45–49.

    CAS  Google Scholar 

  • Lumbers, E. R., and Potter, E. K., 1983, Inhibition of the vagal component of the baroreceptor-car-dioinhibitory reflex by angiotensin III in dogs and sheep, J. Physiol. (Lond.) 336: 83–89.

    CAS  Google Scholar 

  • Lutherer, L. O., Smith, A. L., Chen, C. H., O’Leary, E. L., and Lutherer, B. C., 1983, The effect of angiotensin and vasopressin blockade separately and in combination with cerebellectomy on recovery from hemorrhagic hypotension, Circ. Shock 10: 329–340.

    PubMed  CAS  Google Scholar 

  • Manning, R. D., Guyton, A. C., Coleman, T. G., and McCaa, R. E., 1979, Hypertension in dogs during antidiuretic hormone and hypotonic saline infusion, Am. J., Physiol. 236: H314–H322.

    CAS  Google Scholar 

  • Marchetti, J., Thibonnier, M., Gonzales, M. F., Corvol, P., and Menard, J., 1980, Dynamic study of antidiuretic hormone during benign mineralocorticoid and metacorticoid hypertension, Acta Endocrinol. (Copenh.) 95: 444–453.

    CAS  Google Scholar 

  • Marker, J. D., Miles, T. S., and Scroop, G. C., 1980, Modulation of the baroreceptor reflex by angiotensin II and other vasoactive drugs in anaesthetized greyhounds, Clin. Sci. 58: 7–13.

    PubMed  CAS  Google Scholar 

  • Matsuguchi, H., and Schmid, P. G., 1982a, Pressor response to vasopressin and impaired baroreflex function in DOC-salt hypertension, Am. J. Physiol. 242: H44–H49.

    PubMed  CAS  Google Scholar 

  • Matsuguchi, H., and Schmid, P. G., 1982b, Acute interaction of vasopressin and neurogenic mechanisms in DOC-salt hypertension, Am. J. Physiol. 242: H37–H43.

    PubMed  CAS  Google Scholar 

  • Matsuguchi, H., Schmid, P. G., Van Orden, D., and Mark, A. L., 1981, Does vasopressin contribute to salt-induced hypertension in the Dahl strain?, Hypertension 3: 174–181.

    PubMed  CAS  Google Scholar 

  • Matsuguchi, H., Sharabi, F. M., Gordon, F. J., Johnson, A. K., and Schmid, P. G., 1982, Blood pressure and heart rate responses to microinjection of vasopressin into the nucleus tractus solitarius region of the rat, Neuropharmacology 21: 687–693.

    PubMed  CAS  Google Scholar 

  • McNeill, J. R., 1974, Intestinal vasoconstriction following diuretic-induced volume depletion: Role of angiotensin and vasopressin, Can. J. Physiol. Pharmacol. 52: 829–839.

    PubMed  CAS  Google Scholar 

  • McNeill, J. R., Stark, R. D., and Greenway, C. V., 1979, Intestinal vasoconstriction after hemorrhage: Roles of vasopressin and angiotensin, Am. J. Physiol. 219: 1342–1347.

    Google Scholar 

  • Meisenberg, G., and Simmons, W. H., 1983, Peptides and the blood-brain barrier, Life Sci. 32: 2611–2623.

    PubMed  CAS  Google Scholar 

  • Mens, W. B. J., Bowman, H. J., Bakker, E. A. D., and Greidamus, T. B., 1980, Differential effects of various stimuli on AVP levels in blood and cerebrospinal fluid. Eur. J. Pharmacol 68: 89–92.

    PubMed  CAS  Google Scholar 

  • Merrill, D. C., Quillen, E. W., Jr., Skelton, M. M., and Cowley, A. W., Jr., 1983, Dehydration natri-uresis in the salt-deplete dog—Role of vasopressin and aldosterone, Fed. Proc. 42: 738.

    Google Scholar 

  • Michell, R. H., Kirk, C. J., and Billah, M. M., 1979, Hormonal stimulation of phosphatidylinositol breakdown, with particular reference to the hepatic effects of vasopressin, Biochem. Soc. Trans. 7: 861–865.

    PubMed  CAS  Google Scholar 

  • Mohama, R. E., Joyner, W. L., and Gilmore, J. P., 1984, Comparative reactivity of hamster cheek pouch microvessels to arginine vasopressin and angiotensin II, Microcirc. Endoth. Lymph. 1: 397–413.

    CAS  Google Scholar 

  • Mohring, B., and Mohring, J., 1975, Plasma ADH in normal Long-Evans rats and in Long-Evans rats heterozygous and homozygous for hypothalamic diabetes insipidus, Life Sci. 17: 1307–1314.

    PubMed  CAS  Google Scholar 

  • Mohring, J., Mohring, B., Petri, M., and Haack, D., 1978, Plasma vasopressin concentrations and effects of vasopressin antiserum on blood pressure in rats with malignant two-kdiney Goldblatt hypertension, Circ. Res. 42: 17–22.

    PubMed  CAS  Google Scholar 

  • Mohring, J., Kintz, J., and Schoun, J., 1979, Studies on the role of vasopressin in blood pressure control of spontaneously hypertensive rats with established hypertension (SHR, stroke-prone strain), J. Cardiovasc, Pharmacol. 1: 593–608.

    CAS  Google Scholar 

  • Mohring, J., Glanzer, K., Maciel, J. A., Jr., Dusing, R., Kramer, H. J., Arbogast, R., and Koch-Weser, J., 1980a, Greatly enhanced pressor response to antidiuretic hormone in patients with impaired cardiovascular reflexes due to idiopathic orthostatic hypotension, J. Cardiovasc, Pharmacol 2: 367–376.

    CAS  Google Scholar 

  • Mohring, J., Schoun, J., Kintz, J., and McNeill, J. R., 1980b, Decreased vasopressin content in brain stem of rats with spontaneous hypertension, Naunym-Schmeidebergs Arch. Pharmacol. 315: 83–84.

    CAS  Google Scholar 

  • Mohring, J., Kintz, J., Schoun, J., and McNeill, J. R., 1981, Pressor responsiveness and cardiovascular reflex activity in spontaneously hypertensive and normotensive rats during vasopressin infusion, J. Cardiovasc. Pharmacol. 3: 948–957.

    PubMed  CAS  Google Scholar 

  • Monos, E., Cox, R. H., and Peterson, L. H., 1978, Direct effect of physiological doses of arginine vasopressin on the arterial wall in vivo, Am. J. Physiol. 234: H167–H172.

    PubMed  CAS  Google Scholar 

  • Montani, J. P. Liard, J. F., Schoun, J., and Mohring, J., 1980, Hemodynamic effects of exogenous and endogenous vasopressin at low plasma concentrations in conscious dogs, Circ. Res. 47: 346–355.

    PubMed  CAS  Google Scholar 

  • Morfaux, C., and Bralet, J., 1977, Etude des circulations régionales chez le rat par utilisation de micro-spheres. Influence de la noradrenaline, de l’angiotensine et de la vasopressine, J. Phvsiol. (Paris) 8: 261–268.

    CAS  Google Scholar 

  • Morris, M., 1982, Neurohypophysial response to dehydration in the spontaneously hypertensive rat, Hypertension 4: 161–168.

    PubMed  CAS  Google Scholar 

  • Morris, M., Keller, M., and Sundberg, D. K., 1983, Changes in paraventricular vasopressin and oxytocin during the development of spontaneous hypertension, Hypertension 5: 476–481.

    PubMed  CAS  Google Scholar 

  • Morton, J. J., Padfield, P. L., and Forsling, M. L., 1975, A radioimmunoassay for plasma arginine vasopressin in man and dog: Application to physiological and pathological states, J. Endocrinol. 65: 411–424.

    PubMed  CAS  Google Scholar 

  • Morton, J. J., Rio, C. G. D., and Hughes, M. J., 1982, Effect of acute vasopressin infusion on blood pressure and plasma angiotensin II in normotensive and DOCA-salt hypertensive rats, Clin. Sci. 62: 143–149.

    PubMed  CAS  Google Scholar 

  • Moursi, M. M., Van Wylen, D. G. L., and D’Alecy, L. G., 1985, Regional blood flow changes in response to mildly pressor doses of triglycl desamino lysine and arginine vasopressin in the conscious dog, J. Pharmacol. Exp. Ther. 232: 360–368.

    PubMed  CAS  Google Scholar 

  • Nair, U. C., Hasser, E. M., Undesser, K. P., and Bishop, V. S., 1984, Effect of vasopressin on arterial baroreflex control of renal sympathetic nerve activity during phenylephrine infusions, Fed. Proc. 43: 1068.

    Google Scholar 

  • Nakai, M., Yamane, Y., Umeda, Y., and Ogino, K., 1982, Vasopressin-induced pressor response elicited by electrical stimulation of solitary nucleus and dorsal motor nucleus of vagus of rat, Brain Res. 251: 164–168.

    PubMed  CAS  Google Scholar 

  • Nakano, J., 1974, Cardiovascular responses to neurohypophysial hormones, in: Handbook of Physiology, Section 7: Endocrinology, Vol. IV: The Pituitary Gland and Its Neuroendocrine Control, Part 1 (P.. O. Greep and E. B Astwood. eds.). pp. 395–442. American Physiological Society, Washington, D.C.

    Google Scholar 

  • Nashold, B. S., Mannarino, E. M., and Wunderlich, M., 1961, Pressor-depressor blood pressure response in the cat after intraventricular injection of drugs, Nature 193: 1297–1298.

    Google Scholar 

  • Nussey, S. S., Ang, V. T. Y., Jenkins, J. S., Chowdrey, H. S., and Bisset, G. W., 1984, Brattleboro rat adrenal contains vasopressin, Nature (Lond.) 310: 64–66.

    CAS  Google Scholar 

  • Okuno, T., Winternitz, S. R., Lindheimer, M. D., and Oparil, S., 1983, Central catecholamine depletion, vasopressin, and blood pressure in the DOCA/NaCl rat, Am. J. Physiol. 244: H807–H813.

    PubMed  CAS  Google Scholar 

  • Oliver, H., and Schafer, E. A., 1895, On the physiological action of extracts of the pituitary body and certain other glandular organs, J. Physiol. (Lond.) 18: 277–279.

    CAS  Google Scholar 

  • Osborn, J. W., Jr., Webb, R. L., and Cowley, A. W., Jr. 1987, Hemodynamic and autonomic effects of arginine vasopressin compared to angiotensin II in conscious rats, Am. J. Physiol. 252 (Heart Circ. Physiol. 21): H628–H637.

    PubMed  CAS  Google Scholar 

  • Padfield, P. L., 1977, Vasopressin in hypertension, Am. Heart J. 94: 531–532.

    PubMed  CAS  Google Scholar 

  • Padfield, P. L., Lever, A. F., Brown, J. J., and Robertson, J. I. S., 1976, Changes of vasopressin in hypertension: Cause or effect?, Lancet l(Part 2):1255-1257.

    Google Scholar 

  • Padfield, P. L., Brown, J. J., Lever, A. F., Morton, J. J., and Robertson J. I. S., 1981, Blood pressure in acute and chronic vasopressin excess. Studies of malignant hypertension and the syndrome of inappropriate antidiuretic hormone secretion, N. Engl. J. Med. 304: 1067–1070.

    PubMed  CAS  Google Scholar 

  • Palier, M. S., and Linas, S. L., 1983, Role of vasopressin in support of blood pressure in potassium deficient rats, Kidney Int. 24: 342–347.

    Google Scholar 

  • Pang, C. C. Y., 1983, Effect of vasopressin antagonist and saralasin on regional blood flow following hemorrhage, Am. J. Physiol. 245: H749–H755.

    PubMed  CAS  Google Scholar 

  • Partridge, W. M. 1983, Neuropeptides and the blood-brain barrier, Annu. Rev. Physiol. 45: 73–82.

    Google Scholar 

  • Penit, J., Faure, M, and Jard, S., 1983, Vasopressin and angiotensin II receptors in rat aortic smooth muscle cells in culture, Am. J. Physiol. 244: E72–E82.

    PubMed  CAS  Google Scholar 

  • Philbin, D. M., Wilson, N. E., Sokoloski, J., and Coggins, C., 1976, Radioimmunoassay of antidiuretic hormone during morphine anesthesiology, Can. Anaesth. Soc. J. 23: 290–295.

    PubMed  CAS  Google Scholar 

  • Pittman, Q. J., and Lawrence, D., 1982, Descending hypothalamic pathways: Electrophysiological investigations of their possible functions, in: Neuroendocrinology of Vasopressin, Corticoliberin and Opiomelanocortins (A. J. Baertschi and J. J. Dreifuss, eds.), pp 167–176, Academic, London.

    Google Scholar 

  • Preibisz, J. J., Sealey, J. E., Laragh, J. H., Cody, R. J., and Woksler, B. B., 1983, Plasma and platelet vasopressin in essential hypertension and congestive heart failure, Hypertension 5(Suppl. I): 129–138.

    Google Scholar 

  • Pullan, P. T., Johnston, C. I. Anderson, W. P., and Korner, P. I., 1981, Plasma vasopressin in blood pressure homeostasis and in experimental renal hypertension, Am. J. Physiol. 239: H81–H87.

    Google Scholar 

  • Quillen, E. W., Jr., and Cowley, A. W. Jr., 1983, Influence of volume changes on osmolality-vasopressin relationship in conscious dogs, Am. J. Physiol. 244: H73–H79.

    PubMed  CAS  Google Scholar 

  • Rabito, S. F., Carretero, O. A., and Scicli, A. G., 1981, Evidence against a role of vasopressin in the maintenance of high blood pressure in mineralocorticoid and renovascular hypertension, Hypertension 3: 34–38.

    PubMed  CAS  Google Scholar 

  • Rascher, W., Weidmann, E., and Gross, F., 1981, Vasopressin in the plasma of stroke-prone spontaneously hypertensive rats, Clin. Sci. 61: 295–298.

    PubMed  CAS  Google Scholar 

  • Rascher, W., Lang, R. E., Unger, T., Ganten, D., and Gross, F., 1982, Vasopressin in brain of spontaneously hypertensive rats, Am. J. Physiol. 242: H496–H499.

    PubMed  CAS  Google Scholar 

  • Rascher, W., Lang, R. E., Ganten, D., Meffle, H., Taubitz, M., Unger, T., and Gross, F., 1983, Vasopressin in deoxycorticosterone acetate hypertension of rats: A hemodynamic analysis, J. Cardiovasc. Pharmacol. 5: 418–425.

    PubMed  CAS  Google Scholar 

  • Rasmussen, S. N., 1974, Effects of osmotic diuresis and water diuresis on intrarenal red cell and plasma volumes in the rat, Pflugers Arch. 398: 1–11.

    Google Scholar 

  • Rettig, R., Lang, R. E., Rascher, W., Unger, T., and Ganten, D., 1982, Brain peptides and blood pressure regulation, Clin. Sci. 63: 269s–283s.

    Google Scholar 

  • Robertson, G. L., 1977, The regulation of vasopressin function in health and disease, Recent Prog. Horm. Res. 33: 333–385.

    Google Scholar 

  • Robertson, G. L., Mahr, E. A., Athar, S., and Sinha, T., 1973, Development and clinical application of a new method for the radioimmunoassay of arginine vasopressin in human plasma, J. Clin. Invest. 52: 2340–2352.

    PubMed  CAS  Google Scholar 

  • Robinson, C. A. F., 1983, Neurohypophysial peptides in cerebrospinal fluid, Prog. Brain Res. 60: 129–145.

    PubMed  CAS  Google Scholar 

  • Rochae Silva, M., Jr., and Rosenberg, M., 1969, The release of vasopressin in response to haemorrhage and its role in the mechanism of blood pressure regulation, J. Physiol. (Lond.) 202: 535–557.

    CAS  Google Scholar 

  • Rockhold, R. W., Share, L., Crofton, J. T., and Brooks, D. P., 1984, Cardiovascular response to vasopressin vasopressor antagonist administration during water deprivation in the rat, Neuroendocrinology 38: 139–144.

    PubMed  CAS  Google Scholar 

  • Rose, C. E., Godine, R. L., Rose, K. Y., Anderson, R. J., and Carey, R. M. 1984, Role of arginine vasopressin and angiotensin II in cardiovascular responses to combined acute hypoxemia and hypercapnic acidosis in conscious dogs, J. Clin. Invest. 74: 321–331.

    PubMed  CAS  Google Scholar 

  • Rose, J. C., Jones, C. M, Kelly, R. T., Hargrave, B. Y., and Meis, P. J., 1983, A vasopressin antagonist blocks the norepinephrine and epinephrine responses to hemorrhage in the fetus, Endocrinology 113: 2314–2316.

    PubMed  CAS  Google Scholar 

  • Ross, C. A., Ruggiero, D. A., and Reis, D. J., 1981, Afferent projections to cardiovascular portions of the nucleus of the tractus solitarius in the rat, Brain Res. 223: 402–408.

    PubMed  CAS  Google Scholar 

  • Rurak, D. W., 1978, Plasma vasopressin levels during hypoxaemia and the cardiovascular effects of exogenous vasopressin in foetal and adult sheep, J. Physiol. (Lond.) 277: 341–357.

    CAS  Google Scholar 

  • Saameli, K., 1968, The circulatory actions of the neurohypophysial hormones and similar polypeptides, in: Handbook of Experimental Pharmacology, Vol. 23 (B. Berde, ed.), pp. 545–611, Springer-Verlag, Heidelberg.

    Google Scholar 

  • Sagawa, K., and Watanabe, K. 1965, Summation of bilateral carotid sinus signals in the barostatic reflex, Am. J. Physiol. 209: 1278–1286.

    PubMed  CAS  Google Scholar 

  • Saito, T., and Yajima, Y., 1982, Development of DOCA-salt hypertension in the Brattleboro rat, in: The Brattleboro Rat (H. W. Sokol and H. Valtin, eds.), pp. 309–318, Annals of the New York Academy of Science, New York.

    Google Scholar 

  • Sawyer, W. H., 1971, Neurohypophysial hormones, Pharmacol. Rev. 13: 225–227.

    Google Scholar 

  • Sawyer, W. H., and Manning, M., 1973, Synthetic analogs of oxytocin and the vasopressins, Annu. Rev. Pharmacol. 13: 5–18.

    CAS  Google Scholar 

  • Scher, A. M., and Young, A. C., 1963, Servoanalysis of carotid sinus reflex effects of peripheral resistance, Circ. Res. 12: 152–162.

    PubMed  CAS  Google Scholar 

  • Schiffrin, E. L., and Genest, J., 1983, 3H-vasopressin binding to the rat mesenteric artery, Endocrinology 113: 409–411.

    PubMed  CAS  Google Scholar 

  • Schmid, P. G., Abboud, F. M., Wendling, M. G., Ramberg, E. S., Mark, A. L., Heistad, D. D., and Eckstein, J. W., 1974, Regional vascular effects of vasopressin: Plasma levels and circulatory responses, Am. J. Physiol. 227: 998–1004.

    PubMed  CAS  Google Scholar 

  • Schmid, P. G., Sharabi, F. M., Matsuguchi, H., Schmidt Davis, and Lund, D. D. 1982, Vasopressin and neurogenic control of the circulation, in: Salt and Hypertension (J. Iwai, ed.), pp. 203–230, Igaku-Shoin, New York.

    Google Scholar 

  • Schmitt, S. L., Taylor, K., Schmidt, R., Van Orden, D., and Williamson, H. E., 1981, The role of volume depletion, antidiuretic hormone and angiotensin II in the furosemide-induced decrease in mesenteric conductance in the dog, J. Pharmacol. Exp. Ther. 219: 407–414.

    PubMed  CAS  Google Scholar 

  • Schwartz, J., and Reid, I. A., 1981, Effect of vasopressin blockade on blood pressure regulation during hemorrhage in conscious dogs, Endocrinology 109: 1778–1780.

    PubMed  CAS  Google Scholar 

  • Schwartz, J., and Reid, I. A., 1983a, Role of vasopressin in blood pressure regulation in conscious water-deprived dogs, Am. J. Physiol. 244: R74–R77.

    PubMed  CAS  Google Scholar 

  • Schwartz, J., Keil, L. C., Maselli, J., and Reid, I. A., 1983b, Role of vasopressin in blood pressure regulation during adrenal insufficiency, Endocrinology 112: 234–238.

    PubMed  CAS  Google Scholar 

  • Schwartz, J., Liard, J. F., and Cowley, A. W., Jr., 1985, Cardiovascular actions of the antidiuretic activity of vasopressin, Am. J. Physiol. 249: 1001–1008.

    Google Scholar 

  • Share, L., 1965, Effects of carotid occlusion and left atrial distension on plasma vasopressin, Am. J. Physiol. 208: 219–223.

    PubMed  CAS  Google Scholar 

  • Share, L., Crofton, J. T., Lee-Kwon, W. J., and Shade, R. E., 1982, One clip, one kidney hypertension in rats with hereditary hypothalamic diabetes insipidus, Clin. Exp. Hypertens. A4: 1261–1270.

    Google Scholar 

  • Shido, O., Kifune, A., and Nagasaka, T., 1984, Baroreflex suppression of heat production and fall in body temperature following peripheral administration of vasopressin in rats, Jpn. J. Physiol. 34: 397–406.

    PubMed  CAS  Google Scholar 

  • Silverman, A. J., and Zimmerman, E. A., 1983, Magnocellular neurosecretory system, Annu. Rev. Neurosci. 6: 357–380.

    PubMed  CAS  Google Scholar 

  • Simpson P., and Forsling, M., 1977, The effects of halothane on plasma vasopressin during cardio-pulmonary bypass, Clin. Endocrinol. (Oxf.) 7: 33–39.

    CAS  Google Scholar 

  • Skowsky, W. R., Rosenbloom, A. A. and Fisher, D. A., 1974, Radioimmunoassay measurement of arginine vasopressin in serum: Development and application, J. Clin. Endocrin. Metab. 38: 278–287.

    CAS  Google Scholar 

  • Smith, M. J., Cowley, A. W., Jr., Guyton, A. C., and Manning, R. D., 1979, Acute and chronic effects of vasopressin on blood pressure, electrolytes, and fluid volumes, Am. J. Physiol. 237: F232–F240.

    PubMed  CAS  Google Scholar 

  • Sofroniew, M. V., and Weindl, A., 1981, Central nervous system distribution of vasopressin, oxytocin, and neurophysin, in: Endogenous Peptides and Learning and Memory Processes (J. L. Martinez, ed.), pp. 327–369, Academic, New York.

    Google Scholar 

  • Sofroniew, M. V., Weindl, A., Schrell, U., and Wetzstein, R., 1981, Immunohistochemistry of vasopressin, oxytocin and neurophysin in the hypothalamus and extrahypothalamic regions of the human and primate brain, Acta Histochem. (Suppl.): 19–95.

    Google Scholar 

  • Sokol, H. W., and Zimmerman, E. A., 1982, The hormonal status of the Brattleboro rat, in: The Brattleboro Rat (H. W., Sokol and H. Valtin, eds.), pp. 535–559, The New York Academy of Sciences, New York.

    Google Scholar 

  • Starling, E. H., and Verney, E. B., 1924, The secretion of urine as studied on the isolated kidney, Proc. R. Soc. Lond. (Biol.) 97: 321–363.

    Google Scholar 

  • Stegner, H., Artman, H. G., Leake, R. D., and Fisher, D. A., 1983, Does DDAVP(l-Desamino-8-D-Arginine-Vasopressin) cross the blood-CSF barrier?, Neuroendocrinology 37: 262–265.

    PubMed  CAS  Google Scholar 

  • Sueta, C. A., Hutchins, P. M., and Dusseau, J. W., 1983, Norepinephrine-induced potentiation of arginine vasopressin reactivity in arterioles of the spontaneously hypertensive rat, Hypertension 5: 321–327.

    PubMed  CAS  Google Scholar 

  • Swanson, L. W., and Sawchenko, P. E., 1983, Hypothalamic integration: Organization of the paraven-tricular and supraoptic nuclei, Annu. Rev. Neurosci. 6: 269–324.

    PubMed  CAS  Google Scholar 

  • Szadowska, A., Szmigielska, H., Szmigielski, A., and Mazur, M., 1979, Effect of propranolol and reserpine on the development of vasopressin hypertension in rat, Agressologie 20: 51–56.

    PubMed  CAS  Google Scholar 

  • Szczepanska-Sadowska, E., 1972, The activity of hypothalamo-hypophysial antidiuretic system in conscious dogs, Pflugers Arch. 335: 139–146.

    PubMed  CAS  Google Scholar 

  • Szczepanska-Sadowska, E., 1973, Hemodynamic effects of a moderate increase of the plasma vasopressin level in conscious dogs, Pflugers Arch. 338: 313–322.

    PubMed  CAS  Google Scholar 

  • Thorn, N. A., 1958, Mammalian antidiuretic hormone, Physiol. Rev. 38: 169–195.

    PubMed  CAS  Google Scholar 

  • Thrasher, T. N., Nistal-Herrera, J. F., Keil, L. C., and Ramsay, D. J., 1981, Satiety and inhibition of vasopressin secretion after drinking in dehydrated dogs, Am. J. Physiol. 240: E394–E401.

    PubMed  CAS  Google Scholar 

  • Thurau, L., and Levine, D. Z., 1971, The renal circulation, in: The Kidney. Morphology, Biochemistry, Physiology (C. Rouiller and A. F. Muller, eds.), pp. 1–70, Academic, New York.

    Google Scholar 

  • Tran, L. D., Montastruc, J. L., and Montastruc, P., 1982, Effects of lysine-vasopressin and oxytocin on central cardiovascular control, Br. J. Pharmacol. 77: 69–73.

    PubMed  CAS  Google Scholar 

  • Turlapaty, P. D. M. V., and Altura, B. M., 1982, Effects of neurohypophyseal peptide hormones on isolated coronary arteries: Role of magnesium ions, Magnesium 1: 122–128.

    CAS  Google Scholar 

  • Undesser, K. P., Hasser, E. M., Haywood, J. R., Johnson, A. K., and Bishop, V. S., 1985, Interactions of vasopressin with the area postrema in arterial baroreflex function in conscious rabbits, Circ. Res. 56: 410–417.

    PubMed  CAS  Google Scholar 

  • Varma, S., Bhuwaneshwar, P. J., and Bhargava, K. P., 1969, Mechanism of vasopressin-induced bradycardia in dogs, Circ. Res. 54: 787–792.

    Google Scholar 

  • Vernersson, E., 1984, Cardiac function and central circulation in lysine-vasopressin treatment of experimental burns, Acta Anaesthesiol Scand. 28: 325–330.

    PubMed  CAS  Google Scholar 

  • Versteeg, C. A. M., Bohus, B., and De Jong, W., 1982, Inhibition of centrally-evoked pressor responses by neurohypophyseal peptides and their fragments, Neuropharmacology 21: 1359–1364.

    PubMed  CAS  Google Scholar 

  • Von den Velden, R., 1913, Die Nierenwirkung von Hypophysen extrakten beim Menschen, Berl. Klin. Wochenschr. 50: 2083–2086.

    Google Scholar 

  • Von Cyon, E., 1898, Die physiologischen Herzgifte, II. Hypophysenextracte, Pflugers Arch. 73: 339–373.

    Google Scholar 

  • Waeber, B., Schaller, M. D., Nussberger, J., Bussien, J. P., Hofbauer, K. G., and Brunner, H. R., 1984, Skin blood flow reduction induced by cigarette smoking: Role of vasopressin, Am. J. Physiol. 247: H895–H901.

    PubMed  CAS  Google Scholar 

  • Wagner, H. N., and Braunwald, E., 1956, The pressor effect of the antidiuretic principle of the posterior pituitary in orthostatic hypotension, J. Clin. Invest. 35: 1412–1418.

    PubMed  CAS  Google Scholar 

  • Wang, B. C., Share, L., Crofton, J. T., and Kimura, T. 1981, changes in vasopressin concentration in plasma and cerebrospinal fluid in response to hemorrhage in anesthetized dogs, Neuroendocrinology 33: 61–66.

    PubMed  Google Scholar 

  • Webb, R. L., Osborn, J. W., Jr., and Cowley, A. W., Jr. 1986, Cardiovascular actions of vasopressin: Baroreflex modulation in the conscious rat, Am. J. Physiol. 251(Heart Circ. Physiol. 20): H1244–H1251.

    Google Scholar 

  • Weitzman, R. E., Fisher, D. A., DiStefano, J. J., and Bennett, C. M., 1977, Episodic secretion of arginine vasopressin, Am. J. Physiol. 233: E32–E36.

    PubMed  CAS  Google Scholar 

  • Weitzman, R. E., Reviczky, A., Oddie, T. H., and Fisher, D. A., 1980, Effect of osmolality of arginine vasopressin and renin release after hemorrhage, Am. J. Physiol. 238: E62–E69.

    PubMed  CAS  Google Scholar 

  • Wetterlin, S., Aronsen, K. F., and Ahlgren, I., 1978, Distribution of cardiac output in burned mice after treatment with triglycl vasopressin, Eur. Surg. Res. 10: 134–141.

    PubMed  CAS  Google Scholar 

  • Wood, J. H., 1983, Physiology and pharmacology of peptide, steroid, and other hormones in cerebrospinal fluid, in: Neurobiology of Cerebrospinal Fluid (J. H. Wood, ed.), pp. 43–65, Plenum, New York.

    Google Scholar 

  • Woods, R. L., and Johnston, C. I., 1982, Role of vasopressin in hypertension: Studies using the Brattleboro rat, Am. J. Physiol. 242: F727–F732.

    PubMed  CAS  Google Scholar 

  • Woods, R. L., and Johnston, C. I., 1983, Contribution of vasopressin to the maintenance of blood pressure during dehydration, Am. J. Physiol. 245: F615–F621.

    PubMed  CAS  Google Scholar 

  • Woods, R. L., Abrahams, J. M, Kincaid-Smith, P. and Johnston, C. I., 1983, Malignant hypertension in Brattleboro (vasopressin-deficient) rats. J. Hypertens. 1: 37–43.

    PubMed  CAS  Google Scholar 

  • Wu, W. H., Zbuzek, V. K., and Bellevue, C., 1980, Vasopressin release during cardiac operation, J. Thorac. Cardiovasc. Surg. 79: 83–90.

    PubMed  CAS  Google Scholar 

  • Zerbe, R. L., Bayorh, A., and Feuerstein, G., 1982a, Vasopressin: An essential pressor factor for blood pressure recovery following hemorrhage, Peptides 3: 509–514.

    PubMed  CAS  Google Scholar 

  • Zerbe, R. L., Feuerstein, G., Meyer, D. K., and Kopin, I. J., 1982b, Cardiovascular, sympathetic, and renin-angiotensin system responses to hemorrhage in vasopressin-deficient rats, Endocrinology 111: 608–613.

    PubMed  CAS  Google Scholar 

  • Zimmerhackl, B., Robertson, C. R., and Jamison, R. L., 1985, Effect of arginine vasopressin (AVP) on vasa recta blood flow, Kidney Int. 27: 302.

    Google Scholar 

  • Zimmerman, E. A., 1981, The organization of oxytocin and vasopressin pathways, in: Neurosecret ion and Brain Peptides (J. B. Martin, S. Reichlin, and K. L. Bick, eds.), pp. 63–75, Raven, New York.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1987 Plenum Press, New York

About this chapter

Cite this chapter

Cowley, A.W., Liard, JF. (1987). Cardiovascular Actions of Vasopressin. In: Gash, D.M., Boer, G.J. (eds) Vasopressin. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-8129-1_10

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-8129-1_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-8131-4

  • Online ISBN: 978-1-4615-8129-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics