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UV Radiation Effects

DNA Repair and Mutagenesis

  • Chapter
The Science of Photobiology

Abstract

The first indication that cells might have the capacity to recover from radiation damage was the observation that minor modifications in the postirradiation treatment of the cells (e.g., growth media, temperature, etc.) had a marked effect upon the ultimate viability of irradiated cells. Thus in 1937, Hollaender and Claus found that higher survival levels of UV-irradiated fungal spores could be obtained if they were allowed to remain in water or salt solution for a period of time before assaying for survival. Roberts and Aldous(1) extended these observations by showing that the shapes of the UV radiation survival curves for Escherichia coli could be changed drastically by holding the irradiated cells in media devoid of an energy source for various times before plating on nutrient agar to assay for survival (Fig. 4-1). The molecular basis of this phenomenon, known as liquid-holding recovery, will be discussed along with other “recovery phenomena” in Section 4.1.3.

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Authors and Affiliations

  1. Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California, 94305, USA

    Kendric C. Smith

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  1. Stanford University School of Medicine, Stanford, California, USA

    Kendric C. Smith

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© 1989 Plenum Press, New York

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Smith, K.C. (1989). UV Radiation Effects. In: Smith, K.C. (eds) The Science of Photobiology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-8061-4_4

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  • DOI: https://doi.org/10.1007/978-1-4615-8061-4_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-43059-6

  • Online ISBN: 978-1-4615-8061-4

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