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Cytomegalovirus Infection after Organ Allografting

Prospects for Immunoprophylaxis

  • Chapter
Book cover The Herpesviruses

Part of the book series: The Viruses ((VIRS))

Abstract

Cytomegalovirus (CMV) infection is an important determinant of success following organ allografting. Exposure to an infection with CMV is common in normal persons, with the age-specific prevalence of antibody to CMV exceeding 50% by adulthood in most parts of the world (Wentworth and Alexander, 1971). In the normal host and especially in children, infection with CMV is often asymptomatic, although it may be the cause of atypical mononucleosis syndrome during adolescence and early adulthood (Klemola and Kaariainen, 1965). Uncommonly, it is the cause of more serious illnesses such as pneumonia, encephalitis, or Guillain-Barre syndrome. With the exception of congenital CMV infection, however, CMV is rarely the cause of severe disease in immunologically normal persons.

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  1. Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, Washington, 98104, USA

    Joel D. Meyers

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  1. University of Chicago, Chicago, Illinois, USA

    Bernard Roizman

  2. Sloan-Kettering Institute for Cancer Research, New York, New York, USA

    Carlos Lopez

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Meyers, J.D. (1985). Cytomegalovirus Infection after Organ Allografting. In: Roizman, B., Lopez, C. (eds) The Herpesviruses. The Viruses. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-8021-8_10

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  • DOI: https://doi.org/10.1007/978-1-4615-8021-8_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-8023-2

  • Online ISBN: 978-1-4615-8021-8

  • eBook Packages: Springer Book Archive

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