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The H1 Class of Histone and Diversity in Chromosomal Structure

  • Chapter
Subcellular Biochemistry

Abstract

Models of chromatin structure that accurately predict the mechanisms of cell replication, differentiation, and neoplasia must accommodate two seemingly opposing concepts. The first is one of uniformity, which arises from the fact that the structures of DNA itself is conserved in all living creatures. The second is one of diversity, which arises from the fact that genes may be differentially expressed in different tissues. The obvious candidates for imparting both uniform and diverse structural forms to chromatin are chromosomal proteins, and it is not unreasonable to assume that all levels of structure of the chromosome are controlled by the interaction and reversible modification of various chromosomal proteins.

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  1. Department of Experimental Biology, Roswell Park Memorial Institute, Buffalo, New York, 14263, USA

    Philip Hohmann

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  1. University College London, London, England

    Donald B. Roodyn

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© 1978 Plenum Press, New York

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Hohmann, P. (1978). The H1 Class of Histone and Diversity in Chromosomal Structure. In: Roodyn, D.B. (eds) Subcellular Biochemistry. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-7942-7_2

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  • DOI: https://doi.org/10.1007/978-1-4615-7942-7_2

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